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G1L7Y5

- G1L7Y5_AILME

UniProt

G1L7Y5 - G1L7Y5_AILME

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Protein
Submitted name:

Uncharacterized protein

Gene

EZH2

Organism
Ailuropoda melanoleuca (Giant panda)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. chromatin DNA binding Source: Ensembl
  2. core promoter binding Source: Ensembl
  3. histone-lysine N-methyltransferase activity Source: InterPro
  4. RNA binding Source: Ensembl
  5. sequence-specific DNA binding Source: Ensembl

GO - Biological processi

  1. cellular response to hydrogen peroxide Source: Ensembl
  2. cerebellar cortex development Source: Ensembl
  3. DNA methylation Source: Ensembl
  4. G1 to G0 transition Source: Ensembl
  5. histone H3-K27 methylation Source: Ensembl
  6. negative regulation of epidermal cell differentiation Source: Ensembl
  7. negative regulation of G1/S transition of mitotic cell cycle Source: Ensembl
  8. negative regulation of gene expression, epigenetic Source: Ensembl
  9. negative regulation of retinoic acid receptor signaling pathway Source: Ensembl
  10. negative regulation of striated muscle cell differentiation Source: Ensembl
  11. negative regulation of transcription elongation from RNA polymerase II promoter Source: Ensembl
  12. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  13. positive regulation of epithelial to mesenchymal transition Source: Ensembl
  14. positive regulation of MAP kinase activity Source: Ensembl
  15. positive regulation of Ras GTPase activity Source: Ensembl
  16. protein localization to chromatin Source: Ensembl
  17. regulation of cell proliferation Source: Ensembl
  18. regulation of gliogenesis Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:EZH2Imported
OrganismiAiluropoda melanoleuca (Giant panda)Imported
Taxonomic identifieri9646 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeAiluropoda
ProteomesiUP000008912: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. ESC/E(Z) complex Source: Ensembl
  3. nuclear chromatin Source: Ensembl
  4. pronucleus Source: Ensembl
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains SET domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118855.
InParanoidiG1L7Y5.
KOiK11430.
OMAiNRDDKES.
OrthoDBiEOG7VB2DR.
TreeFamiTF314509.

Family and domain databases

InterProiIPR026489. CXC_dom.
IPR021654. EZH2_WD-Binding.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11616. EZH2_WD-Binding. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51633. CXC. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G1L7Y5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGQTGKKSEK GPVCWRKRVK SEYMRLRQLK RFRRADEVKS MFSSNRQKIL
60 70 80 90 100
ERTEILNQEW KQRRIQPVHI LTSVSSLRGT RECSVTSDLD FPTQVIPLKT
110 120 130 140 150
LNAVASVPIM YSWSPLQQNF MVEDETVLHN IPYMGDEVLD QDGTFIEELI
160 170 180 190 200
KNYDGKVHGD RECGFINDEI FVELVNALGQ YNDDDDDDDG DDPDEREEKQ
210 220 230 240 250
KDLEENRDDK ESRPPRKFPS DKIFEAISSM FPDKGTAEEL KEKYKELTEQ
260 270 280 290 300
QLPGALPPEC TPNIDGPNAK SVQREQSLHS FHTLFCRRCF KYDCFLHRKC
310 320 330 340 350
NYSFHATPNT YKRKNTETAL DNKPCGPQCY QHLEGAKEFA AALTAERIKT
360 370 380 390 400
PPKRPGGRRR GRLPNNSSRP STPTINVLES KDTDSDREAG TETGGENNDK
410 420 430 440 450
EEEEKKDETS SSSEANSRCQ TPIKMKPNIE PPENVEWSGA EASMFRVLIG
460 470 480 490 500
TYYDNFCAIA RLIGTKTCRQ VYEFRVKESS IIAPAPAEDV DTPPRKKKRK
510 520 530 540 550
HRLWAAHCRK IQLKKDGSSN HVYNYQPCDH PRQPCDSSCP CVIAQNFCEK
560 570 580 590 600
FCQCSSECQN RFPGCRCKAQ CNTKQCPCYL AVRECDPDLC LTCGAADHWD
610 620 630 640 650
SKNVSCKNCS IQRGSKKHLL LAPSDVAGWG IFIKDPVQKN EFISEYCGEI
660 670 680 690 700
ISQDEADRRG KVYDKYMCSF LFNLNNDFVV DATRKGNKIR FANHSVNPNC
710 720 730 740 750
YAKVMMVNGD HRIGIFAKRA IQTGEELFFD YRYSQADALK YVGIEREMEI

P
Length:751
Mass (Da):85,995
Last modified:October 19, 2011 - v1
Checksum:i956B9F59D4088AED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACTA01090061 Genomic DNA. No translation available.
ACTA01098061 Genomic DNA. No translation available.
ACTA01106061 Genomic DNA. No translation available.
RefSeqiXP_002923814.1. XM_002923768.1.

Genome annotation databases

EnsembliENSAMET00000003127; ENSAMEP00000003001; ENSAMEG00000002791.
GeneIDi100466177.
KEGGiaml:100466177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACTA01090061 Genomic DNA. No translation available.
ACTA01098061 Genomic DNA. No translation available.
ACTA01106061 Genomic DNA. No translation available.
RefSeqi XP_002923814.1. XM_002923768.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSAMET00000003127 ; ENSAMEP00000003001 ; ENSAMEG00000002791 .
GeneIDi 100466177.
KEGGi aml:100466177.

Organism-specific databases

CTDi 2146.

Phylogenomic databases

GeneTreei ENSGT00760000118855.
InParanoidi G1L7Y5.
KOi K11430.
OMAi NRDDKES.
OrthoDBi EOG7VB2DR.
TreeFami TF314509.

Family and domain databases

InterProi IPR026489. CXC_dom.
IPR021654. EZH2_WD-Binding.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11616. EZH2_WD-Binding. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00717. SANT. 2 hits.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS51633. CXC. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence and de novo assembly of the giant panda genome."
    Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.
    , Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L., Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J., Wang J.
    Nature 463:311-317(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiG1L7Y5_AILME
AccessioniPrimary (citable) accession number: G1L7Y5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: October 29, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3