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G1L7Y5

- G1L7Y5_AILME

UniProt

G1L7Y5 - G1L7Y5_AILME

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Protein
Submitted name: Uncharacterized protein
Gene
EZH2
Organism
Ailuropoda melanoleuca (Giant panda)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. RNA binding Source: Ensembl
  2. chromatin binding Source: Ensembl
  3. core promoter binding Source: Ensembl
  4. histone-lysine N-methyltransferase activity Source: InterPro
  5. sequence-specific DNA binding Source: Ensembl

GO - Biological processi

  1. G1 to G0 transition Source: Ensembl
  2. cerebellar cortex development Source: Ensembl
  3. histone H3-K27 methylation Source: Ensembl
  4. negative regulation of G1/S transition of mitotic cell cycle Source: Ensembl
  5. negative regulation of epidermal cell differentiation Source: Ensembl
  6. negative regulation of gene expression, epigenetic Source: Ensembl
  7. negative regulation of retinoic acid receptor signaling pathway Source: Ensembl
  8. negative regulation of striated muscle cell differentiation Source: Ensembl
  9. negative regulation of transcription elongation from RNA polymerase II promoter Source: Ensembl
  10. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  11. positive regulation of MAP kinase activity Source: Ensembl
  12. positive regulation of Ras GTPase activity Source: Ensembl
  13. positive regulation of epithelial to mesenchymal transition Source: Ensembl
  14. regulation of cell proliferation Source: Ensembl
  15. regulation of gliogenesis Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:EZH2Imported
OrganismiAiluropoda melanoleuca (Giant panda)Imported
Taxonomic identifieri9646 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeAiluropoda
ProteomesiUP000008912: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. ESC/E(Z) complex Source: Ensembl
  2. pronucleus Source: Ensembl
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains SET domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00740000115009.
KOiK11430.
OMAiNRDDKES.
OrthoDBiEOG7VB2DR.
TreeFamiTF314509.

Family and domain databases

InterProiIPR026489. CXC_dom.
IPR021654. EZH2_WD-Binding.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11616. EZH2_WD-Binding. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51633. CXC. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G1L7Y5-1 [UniParc]FASTAAdd to Basket

« Hide

MGQTGKKSEK GPVCWRKRVK SEYMRLRQLK RFRRADEVKS MFSSNRQKIL    50
ERTEILNQEW KQRRIQPVHI LTSVSSLRGT RECSVTSDLD FPTQVIPLKT 100
LNAVASVPIM YSWSPLQQNF MVEDETVLHN IPYMGDEVLD QDGTFIEELI 150
KNYDGKVHGD RECGFINDEI FVELVNALGQ YNDDDDDDDG DDPDEREEKQ 200
KDLEENRDDK ESRPPRKFPS DKIFEAISSM FPDKGTAEEL KEKYKELTEQ 250
QLPGALPPEC TPNIDGPNAK SVQREQSLHS FHTLFCRRCF KYDCFLHRKC 300
NYSFHATPNT YKRKNTETAL DNKPCGPQCY QHLEGAKEFA AALTAERIKT 350
PPKRPGGRRR GRLPNNSSRP STPTINVLES KDTDSDREAG TETGGENNDK 400
EEEEKKDETS SSSEANSRCQ TPIKMKPNIE PPENVEWSGA EASMFRVLIG 450
TYYDNFCAIA RLIGTKTCRQ VYEFRVKESS IIAPAPAEDV DTPPRKKKRK 500
HRLWAAHCRK IQLKKDGSSN HVYNYQPCDH PRQPCDSSCP CVIAQNFCEK 550
FCQCSSECQN RFPGCRCKAQ CNTKQCPCYL AVRECDPDLC LTCGAADHWD 600
SKNVSCKNCS IQRGSKKHLL LAPSDVAGWG IFIKDPVQKN EFISEYCGEI 650
ISQDEADRRG KVYDKYMCSF LFNLNNDFVV DATRKGNKIR FANHSVNPNC 700
YAKVMMVNGD HRIGIFAKRA IQTGEELFFD YRYSQADALK YVGIEREMEI 750
P 751
Length:751
Mass (Da):85,995
Last modified:October 19, 2011 - v1
Checksum:i956B9F59D4088AED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACTA01090061 Genomic DNA. No translation available.
ACTA01098061 Genomic DNA. No translation available.
ACTA01106061 Genomic DNA. No translation available.
RefSeqiXP_002923814.1. XM_002923768.1.

Genome annotation databases

EnsembliENSAMET00000003127; ENSAMEP00000003001; ENSAMEG00000002791.
GeneIDi100466177.
KEGGiaml:100466177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACTA01090061 Genomic DNA. No translation available.
ACTA01098061 Genomic DNA. No translation available.
ACTA01106061 Genomic DNA. No translation available.
RefSeqi XP_002923814.1. XM_002923768.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSAMET00000003127 ; ENSAMEP00000003001 ; ENSAMEG00000002791 .
GeneIDi 100466177.
KEGGi aml:100466177.

Organism-specific databases

CTDi 2146.

Phylogenomic databases

GeneTreei ENSGT00740000115009.
KOi K11430.
OMAi NRDDKES.
OrthoDBi EOG7VB2DR.
TreeFami TF314509.

Family and domain databases

InterProi IPR026489. CXC_dom.
IPR021654. EZH2_WD-Binding.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11616. EZH2_WD-Binding. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00717. SANT. 2 hits.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS51633. CXC. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence and de novo assembly of the giant panda genome."
    Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.
    , Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L., Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J., Wang J.
    Nature 463:311-317(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiG1L7Y5_AILME
AccessioniPrimary (citable) accession number: G1L7Y5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: April 16, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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