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Protein

Lactoylglutathione lyase

Gene

GLO1

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.UniRule annotation

Catalytic activityi

(R)-S-lactoylglutathione = glutathione + methylglyoxal.UniRule annotation

Cofactori

Zn2+UniRule annotation

Pathwayi: methylglyoxal degradation

This protein is involved in step 1 of the subpathway that synthesizes (R)-lactate from methylglyoxal.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Lactoylglutathione lyase (GLO1)
  2. no protein annotated in this organism
This subpathway is part of the pathway methylglyoxal degradation, which is itself part of Secondary metabolite metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-lactate from methylglyoxal, the pathway methylglyoxal degradation and in Secondary metabolite metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotation
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00619; UER00675.

Names & Taxonomyi

Protein namesi
Recommended name:
Lactoylglutathione lyaseUniRule annotation (EC:4.4.1.5UniRule annotation)
Alternative name(s):
Glyoxalase IUniRule annotation
Gene namesi
Name:GLO1Imported
OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
Taxonomic identifieri28377 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
Proteomesi
  • UP000001646 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSACAG00000014303.

Interactioni

Protein-protein interaction databases

STRINGi28377.ENSACAP00000014057.

Structurei

3D structure databases

ProteinModelPortaliG1KPR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 176VOCInterPro annotationAdd BLAST147

Sequence similaritiesi

Belongs to the glyoxalase I family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IU7X. Eukaryota.
ENOG4111FDV. LUCA.
GeneTreeiENSGT00390000009312.
InParanoidiG1KPR9.
OrthoDBiEOG091G0GMY.
TreeFamiTF105011.

Family and domain databases

Gene3Di3.10.180.10. 1 hit.
InterProiView protein in InterPro
IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR004360. Glyas_Fos-R_dOase_dom.
IPR004361. Glyoxalase_1.
IPR018146. Glyoxalase_1_CS.
IPR037523. VOC.
PfamiView protein in Pfam
PF00903. Glyoxalase. 1 hit.
SUPFAMiSSF54593. SSF54593. 1 hit.
TIGRFAMsiTIGR00068. glyox_I. 1 hit.
PROSITEiView protein in PROSITE
PS00934. GLYOXALASE_I_1. 1 hit.
PS00935. GLYOXALASE_I_2. 1 hit.
PS51819. VOC. 1 hit.

Sequencei

Sequence statusi: Complete.

G1KPR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQAELSGL TDEEAYSACS DPHPSTKDFL MQQTMLRVKD PKKSLDFYTR
60 70 80 90 100
VLGMTLLQKF DFPTMKFSLY FLAYEDKNDI PKDAKEKTAW TFSRKATIEL
110 120 130 140 150
THNWGTENDE NQAYHNGNSD PRGFGHIGIA VPDVNAACKR FEELGVKFVK
160 170 180
KPDDGKMKGL AFVQDPDGYW IEILNPNHMV TLT
Length:183
Mass (Da):20,851
Last modified:June 26, 2013 - v2
Checksum:i80E67B772768E2F2
GO

Sequence databases

RefSeqiXP_003215951.1. XM_003215903.3.
XP_008123390.1. XM_008125183.2.

Genome annotation databases

EnsembliENSACAT00000014344; ENSACAP00000014057; ENSACAG00000014303.
GeneIDi100567895.

Similar proteinsi

Entry informationi

Entry nameiG1KPR9_ANOCA
AccessioniPrimary (citable) accession number: G1KPR9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: December 20, 2017
This is version 44 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported