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Protein

Tyrosine-protein kinase receptor

Gene

NTRK2

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:NTRK2Imported
OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
Taxonomic identifieri28377 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
Proteomesi
  • UP000001646 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei451 – 474HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_500341253836 – 864Tyrosine-protein kinase receptorSequence analysisAdd BLAST829

Keywords - PTMi

Disulfide bondSAAS annotation, PhosphoproteinUniRule annotation

Expressioni

Gene expression databases

BgeeiENSACAG00000000978.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliG1K941.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini203 – 288Ig-likeInterPro annotationAdd BLAST86
Domaini580 – 849Protein kinaseInterPro annotationAdd BLAST270

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118818.
InParanoidiG1K941.
OrthoDBiEOG091G01JY.
TreeFamiTF106465.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom_sf.
IPR001611. Leu-rich_rpt.
IPR032675. LRR_dom_sf.
IPR031635. NTRK_C2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR020455. Tyr_kin_neurotrophic_rcpt_2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR020777. Tyr_kinase_NGF_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
PfamiView protein in Pfam
PF07679. I-set. 2 hits.
PF13855. LRR_8. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF16920. TPKR_C2. 1 hit.
PRINTSiPR01939. NTKRECEPTOR.
PR01941. NTKRECEPTOR2.
PR00109. TYRKINASE.
SMARTiView protein in SMART
SM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
SM00082. LRRCT. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF52058. SSF52058. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS51450. LRR. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.

Sequencei

Sequence statusi: Complete.

G1K941-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGARPRTRRR TEAPLWWGLG CLVLLGGWRA PLASASACPA PCACSPERIW
60 70 80 90 100
CSEPAPSLRS FPVLGKRSER EKIADIYIAN QRQLESINEI DVGLYTGLKN
110 120 130 140 150
LTVVDSGLKF VSRQAFLKNT NLQYINLSRN KLSSLSRKSF RHLNLSDLIL
160 170 180 190 200
EGNPFKCSCD IMWIKVFQES KNPKTETQDF YCMNDNNQRI SLMEKPVPNC
210 220 230 240 250
GLPSVKLSTH NFTVVEGGSI TLYCDASGSP PPSISWLFNN IASKYESDTN
260 270 280 290 300
KNPASLTIKN VFSNDSGVQI SCVAENSVGE DQDSVDLAVF FPPNITFLEV
310 320 330 340 350
PYPDHHWCIP FSVRGNPQPT LTWLHDGVKL NETDFIFTKI HDSNRSEHHG
360 370 380 390 400
CLHLDNPTHV NNGNYTLVAQ NPYGKDEANI TAYFMEDPGE QYAECWSSSS
410 420 430 440 450
DETELTGSPF YDHAGYSDDY GTTTNDFEDT TNNSNPVTST DVSNKDNEDS
460 470 480 490 500
ITVYVVVGIA ALVCTGLVIM LIILKFGRHS KFGMKVELKQ VGLVEQMWLS
510 520 530 540 550
LQDYDNEGPS SVISNDDDSA SPLHHISNGS NTPSSSEGGP DAVIIGMTKI
560 570 580 590 600
PVIENPQYFG ITNSQLKPDT FVQHIKRHNI VLKRELGEGA FGKVFLAECY
610 620 630 640 650
NLCPEQDKIL VAVKTLKDAS DNARKDFHRE AELLTNLQHD HIVKFYGVCV
660 670 680 690 700
EGDPLIMVFE YMKHGDLNKF LRAHGPDAVL MAEGNLLAEL TQSQMLHIAQ
710 720 730 740 750
QIAAGMVYLA SQHFVHRDLA TRNCLVGENL LVKIGDFGMS RDVYSTDYYR
760 770 780 790 800
VGGHTMLPIR WMPPESIMYR KFTTESDVWS LGVVLWEIFT YGKQPWYQLS
810 820 830 840 850
NNEVIECITQ GRVLQRPRTC PKEVYDLMLG CWQREPHMRL NIKEIHSLLQ
860
NLAKASPVYL DILG
Length:864
Mass (Da):96,895
Last modified:June 26, 2013 - v2
Checksum:i65E5BE48788B0CAF
GO

Sequence databases

RefSeqiXP_016846487.1. XM_016990998.1.

Genome annotation databases

EnsembliENSACAT00000001095; ENSACAP00000001066; ENSACAG00000000978.
GeneIDi100558067.

Similar proteinsi

Entry informationi

Entry nameiG1K941_ANOCA
AccessioniPrimary (citable) accession number: G1K941
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: November 22, 2017
This is version 55 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported