ID   G1K3R9_CICAR            Unreviewed;       227 AA.
AC   G1K3R9;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   SubName: Full=Lectin {ECO:0000313|PDB:4HSD};
OS   Cicer arietinum (Chickpea) (Garbanzo).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; Hologalegina; IRL clade; Cicereae; Cicer.
OX   NCBI_TaxID=3827;
RN   [1] {ECO:0007829|PDB:4HSD}
RP   X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS).
RA   Kumar S., Singh A., Bhushan A., Dey S., Sharma S., Singh T.P.;
RT   "Crystal structure of a new form of plant lectin from Cicer arietinum at
RT   2.45 Angstrom resolution.";
RL   Submitted (OCT-2012) to the PDB data bank.
RN   [2] {ECO:0007829|PDB:4LL2}
RP   X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH CALCIUM.
RA   Kumar S., Dube D., Bhushan A., Dey S., Sharma S., Singh T.P.;
RT   "Crystal structure plant lectinwith two metal binding sites from cicer
RT   arietinum at 2.6 angstrom resolution.";
RL   Submitted (JUL-2013) to the PDB data bank.
RN   [3] {ECO:0007829|PDB:4OEI}
RP   X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 4-227 IN COMPLEX WITH MAGNESIUM.
RA   Kumar S., Dube D., Bhushan A., Dey S., Sharma S., Singh T.P.;
RT   "Crystal structure of plant lectin from Cicer arietinum at2.6 angstrom
RT   resolution.";
RL   Submitted (JAN-2014) to the PDB data bank.
RN   [4] {ECO:0007829|PDB:3V6N}
RP   X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) IN COMPLEX WITH CALCIUM.
RX   PubMed=25559942; DOI=10.1007/s00425-014-2236-6;
RA   Sharma U., Katre U.V., Suresh C.G.;
RT   "Crystal structure of a plant albumin from Cicer arietinum (chickpea)
RT   possessing hemopexin fold and hemagglutination activity.";
RL   Planta 241:1061-1073(2015).
RN   [5] {ECO:0007829|PDB:4YEH}
RP   X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 4-227 IN COMPLEX WITH MAGNESIUM.
RX   PubMed=26242869; DOI=10.1007/s10930-015-9624-z;
RA   Kumar S., Singh A., Yamini S., Dey S., Singh T.P.;
RT   "Crystal Structure of Mg(2+) Containing Hemopexin-Fold Protein from Kabuli
RT   Chana (Chickpea-White, CW-25) at 2.45 A Resolution Reveals Its Metal Ion
RT   Transport Property.";
RL   Protein J. 34:284-290(2015).
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DR   PDB; 3V6N; X-ray; 2.20 A; A/B=1-227.
DR   PDB; 4HSD; X-ray; 2.45 A; A/B=1-227.
DR   PDB; 4LL2; X-ray; 2.60 A; A/B=1-227.
DR   PDB; 4OEI; X-ray; 2.60 A; A/B=4-227.
DR   PDB; 4YEH; X-ray; 2.45 A; A/B=4-227.
DR   PDBsum; 3V6N; -.
DR   PDBsum; 4HSD; -.
DR   PDBsum; 4LL2; -.
DR   PDBsum; 4OEI; -.
DR   PDBsum; 4YEH; -.
DR   AlphaFoldDB; G1K3R9; -.
DR   SMR; G1K3R9; -.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.110.10.10; Hemopexin-like domain; 1.
DR   InterPro; IPR036375; Hemopexin-like_dom_sf.
DR   InterPro; IPR018487; Hemopexin-like_repeat.
DR   Pfam; PF00045; Hemopexin; 1.
DR   SMART; SM00120; HX; 4.
DR   SUPFAM; SSF50923; Hemopexin-like domain; 1.
DR   PROSITE; PS51642; HEMOPEXIN_2; 2.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:3V6N, ECO:0007829|PDB:4HSD};
KW   Calcium {ECO:0007829|PDB:3V6N, ECO:0007829|PDB:4LL2};
KW   Metal-binding {ECO:0007829|PDB:3V6N, ECO:0007829|PDB:4LL2}.
FT   REPEAT          117..164
FT                   /note="Hemopexin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT   REPEAT          170..220
FT                   /note="Hemopexin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT   BINDING         7
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0007829|PDB:3V6N, ECO:0007829|PDB:4LL2"
FT   BINDING         7
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0007829|PDB:4OEI, ECO:0007829|PDB:4YEH"
FT   BINDING         65
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0007829|PDB:3V6N, ECO:0007829|PDB:4LL2"
FT   BINDING         65
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0007829|PDB:4OEI, ECO:0007829|PDB:4YEH"
FT   BINDING         121
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0007829|PDB:3V6N, ECO:0007829|PDB:4LL2"
FT   BINDING         121
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0007829|PDB:4OEI, ECO:0007829|PDB:4YEH"
FT   BINDING         174
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0007829|PDB:3V6N, ECO:0007829|PDB:4LL2"
FT   BINDING         174
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0007829|PDB:4OEI, ECO:0007829|PDB:4YEH"
SQ   SEQUENCE   227 AA;  25698 MW;  F8A211EEB62873EB CRC64;
     TKTGYINAAF RSSRNNEAYL FINDKYVLLD YAPGTSNDKV LYGPSFVRDG YKSLAKTIFG
     TYGIDCSFDT EYNEAFIFYE NFCARIDYAP HSDKDKIISG PKKIADMFPF FKGTVFENGI
     DAAFRSTKGK EVYLFKGDKY ARIDYLTNRL VQNIKSISDG FPCLRGTIFE AGMDSAFASH
     KTNEAYLFKG EYYARINFTP GSTNDIMGGV KKTLDYWPSL RGIIPLE
//