ID   G0WH93_NAUDC            Unreviewed;       471 AA.
AC   G0WH93;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE            EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
GN   Name=NDAI0J02790 {ECO:0000313|EMBL:CCD27171.1};
GN   OrderedLocusNames=NDAI_0J02790 {ECO:0000313|EMBL:CCD27171.1};
OS   Naumovozyma dairenensis (strain ATCC 10597 / BCRC 20456 / CBS 421 / NBRC
OS   0211 / NRRL Y-12639) (Saccharomyces dairenensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Naumovozyma.
OX   NCBI_TaxID=1071378 {ECO:0000313|EMBL:CCD27171.1, ECO:0000313|Proteomes:UP000000689};
RN   [1] {ECO:0000313|EMBL:CCD27171.1, ECO:0000313|Proteomes:UP000000689}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10597 / BCRC 20456 / CBS 421 / NBRC 0211 / NRRL Y-12639
RC   {ECO:0000313|Proteomes:UP000000689};
RX   PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA   Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA   Wolfe K.H.;
RT   "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT   accidents.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|ARBA:ARBA00009225, ECO:0000256|RuleBase:RU362007}.
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DR   EMBL; HE580276; CCD27171.1; -; Genomic_DNA.
DR   RefSeq; XP_003672414.1; XM_003672366.1.
DR   AlphaFoldDB; G0WH93; -.
DR   STRING; 1071378.G0WH93; -.
DR   GeneID; 11494508; -.
DR   KEGG; ndi:NDAI_0J02790; -.
DR   eggNOG; KOG1369; Eukaryota.
DR   HOGENOM; CLU_014393_4_1_1; -.
DR   OMA; TICTRLA; -.
DR   OrthoDB; 2017486at2759; -.
DR   UniPathway; UPA00109; UER00180.
DR   Proteomes; UP000000689; Chromosome 10.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.40.367.20; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; HEXOKINASE; 1.
DR   PANTHER; PTHR19443:SF24; HEXOKINASE YLR446W-RELATED; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 1.
DR   PRINTS; PR00475; HEXOKINASE.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362007};
KW   Glycolysis {ECO:0000256|RuleBase:RU362007};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU362007};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU362007};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000689};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362007}.
FT   DOMAIN          38..224
FT                   /note="Hexokinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00349"
FT   DOMAIN          246..470
FT                   /note="Hexokinase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03727"
SQ   SEQUENCE   471 AA;  52904 MW;  A67460BB3FB32BB9 CRC64;
     MTTATVTTTN ATAMTRSNSI NNTDDSSFLW DDLKHWLTPK HSLPEAIQLF QNELQERLNT
     STVSMIPTKS LSKGIRSSIL DNVVAVNHKR ILAIDFGGTR LKFAFVSMPD CKIQSQHDLE
     ITNKIVNQDF FNDIIGWIVN HPSFLSNLDS IEDIDNDLLV AVTFSFPLNE RKEIVAMGKG
     FVMTDDLVGV PLDSILKKSF IENGMPNVKI GDIINDSVAV YLTSEVFCPQ QIIGTKGENE
     DVNSFSLILG TGTNSCFELP FDSLPVFKQW QFKDSLKKNE NVKSSIINSE IGFLGTFIDL
     APFDISTNRY SKINMPLETI TSGKYIPIIL QNILQDYHII SNLQSSAIKF DGQLVCELVK
     QKNLTKLSLK YEEKFGLSLE QLIIVQKIAI LLIQRAAFYL VGALKAIINL KYTKIVEENE
     NQVFQFGYVG SFLQYCTFFQ DQISIYSNNT IQLQFLEDSN LIGAAIAAFM N
//