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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

NDAI0C03810

Organism
Naumovozyma dairenensis (strain ATCC 10597 / BCRC 20456 / CBS 421 / NBRC 0211 / NRRL Y-12639) (Saccharomyces dairenensis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathway:itricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (NDAI0C03810), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (NDAI0H00250), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (NDAI0D04950)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Electron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
Name:NDAI0C03810Imported
Ordered Locus Names:NDAI_0C03810Imported
OrganismiNaumovozyma dairenensis (strain ATCC 10597 / BCRC 20456 / CBS 421 / NBRC 0211 / NRRL Y-12639) (Saccharomyces dairenensis)Imported
Taxonomic identifieri1071378 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNaumovozyma
ProteomesiUP000000689 Componenti: Chromosome 3

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MembraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi1071378.XP_003669284.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

KOiK00234.
OrthoDBiEOG7V76G3.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G0W8D0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLRTRVAT LPIKRTLLLQ KSFFSTTRSC KLATTTTDTT TPFDNKDYHI
60 70 80 90 100
IDHEYDCVVV GAGGAGLRAA FGLAEAGFKT ACISKLFPTR SHTVAAQGGI
110 120 130 140 150
NAALGNMHPD DWKWHMYDTV KGSDWLGDQD SIHYMTREAP HSIIELEHYG
160 170 180 190 200
MPFSRTEEGK IYQRAFGGQT KEYGKGEQAY RTCAVADRTG HAMLHTLYGQ
210 220 230 240 250
ALRHDTHFFI EFFAMDLLTH NGEVVGVIAY NQEDGTIHRF RAHKTVLATG
260 270 280 290 300
GYGRAYFSCT SAHTCTGDGN AMVSRAGFPL QDLEFVQFHP SGIYGSGCLI
310 320 330 340 350
TEGARGEGGF LVNSEGERFM ERYAPTAKDL ACRDVVSRAI TLEIREGRGV
360 370 380 390 400
GNEKDHMFLQ LNHLPPSVLK ERLPGISETA SIFAGVDVTK EPIPILPTVH
410 420 430 440 450
YNMGGIPTKW NGEALTIDEE TGEDKVIPGL MACGEAACVS VHGANRLGAN
460 470 480 490 500
SLLDLVVFGR AVAHTVADTL QPNTPHKPVP ADIGKESIAN LDKIRNANGS
510 520 530 540 550
RTTAEIRMNM KKTMQKDVSV FRTQESLDEG VSNITAVDKT FDDVKISDRS
560 570 580 590 600
LIWNSDLVET LELQNLLTCA TQTAVSAAAR KESRGAHARE DYPDRDDENW
610 620 630 640
MKHTLSWQSK AGAPVELKYR NVISTTLDEA ECPSVPPTVR SY
Length:642
Mass (Da):70,524
Last modified:October 19, 2011 - v1
Checksum:i53353B3CC4D8A313
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE580269 Genomic DNA. Translation: CCD24041.1.
RefSeqiXP_003669284.1. XM_003669236.1.

Genome annotation databases

GeneIDi11496474.
KEGGindi:NDAI_0C03810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE580269 Genomic DNA. Translation: CCD24041.1.
RefSeqiXP_003669284.1. XM_003669236.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi1071378.XP_003669284.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11496474.
KEGGindi:NDAI_0C03810.

Phylogenomic databases

KOiK00234.
OrthoDBiEOG7V76G3.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolutionary erosion of yeast sex chromosomes by mating-type switching accidents."
    Gordon J.L., Armisen D., Proux-Wera E., Oheigeartaigh S.S., Byrne K.P., Wolfe K.H.
    Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10597 / BCRC 20456 / CBS 421 / NBRC 0211 / NRRL Y-12639Imported.

Entry informationi

Entry nameiG0W8D0_NAUDC
AccessioniPrimary (citable) accession number: G0W8D0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: July 22, 2015
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.