Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alanine racemase

Gene

MELS_1476

Organism
Megasphaera elsdenii DSM 20460
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (MELS_1476)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei46Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei145SubstrateUniRule annotation1
Active sitei276Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei324Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMELS1064535:G1H7Q-1547-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
ORF Names:MELS_1476Imported
OrganismiMegasphaera elsdenii DSM 20460Imported
Taxonomic identifieri1064535 [NCBI]
Taxonomic lineageiBacteriaFirmicutesNegativicutesVeillonellalesVeillonellaceaeMegasphaera
Proteomesi
  • UP000010111 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi1064535.MELS_1476

Structurei

3D structure databases

ProteinModelPortaliG0VQJ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini255 – 383Ala_racemase_CInterPro annotationAdd BLAST129

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
KOiK01775
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

G0VQJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAYESTMNF TRRAVWAQID LDAAAHNMRQ IRKHVGPDVK IAAVVKANAY
60 70 80 90 100
GHGSVELAKT FAENGADCFA VSSLDEAVEL RRYAHIDKEI FILGHTDARR
110 120 130 140 150
TEELLTYDIE PAVFNLKNAE FFSQEAQRLG KTLRVHIAVD TGMSRVGFQV
160 170 180 190 200
NEFSVSEIKA IAALPNIEIR GMFTHFAVSD IKDKTFTREQ YGHFRWMCKR
210 220 230 240 250
MEEEGIHIAL RHCCNSAAAL ELPEYYCDMV RPGIIMYGCE PSPDVDIKPY
260 270 280 290 300
DLRPVMSLRC CIAHVKLIDA GATVSYGRHY TAPSRRKIAT LPVGYADGYS
310 320 330 340 350
RILSGKVDVL YHGHRVPQVG AICMDQCMID VSGEANVHAG DEVVLFGRQG
360 370 380 390
DSFIPIEEIA AACGTINYEI MCDISRRVPR VYMKNGKVVG REEYLFDKP
Length:399
Mass (Da):44,739
Last modified:October 19, 2011 - v1
Checksum:i62E05F70386760BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE576794 Genomic DNA Translation: CCC73697.1
RefSeqiWP_014016427.1, NC_015873.1

Genome annotation databases

EnsemblBacteriaiCCC73697; CCC73697; MELS_1476
KEGGimed:MELS_1476

Similar proteinsi

Entry informationi

Entry nameiG0VQJ7_MEGEL
AccessioniPrimary (citable) accession number: G0VQJ7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: February 28, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health