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G0VQJ7

- G0VQJ7_MEGEL

UniProt

G0VQJ7 - G0VQJ7_MEGEL

Protein

Alanine racemase

Gene

MELS_1476

Organism
Megasphaera elsdenii DSM 20460
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei46 – 461Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei145 – 1451SubstrateUniRule annotation
    Active sitei276 – 2761Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei324 – 3241Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    ORF Names:MELS_1476Imported
    OrganismiMegasphaera elsdenii DSM 20460Imported
    Taxonomic identifieri1064535 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesNegativicutesSelenomonadalesVeillonellaceaeMegasphaera
    ProteomesiUP000010111: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei46 – 461N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliG0VQJ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G0VQJ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNAYESTMNF TRRAVWAQID LDAAAHNMRQ IRKHVGPDVK IAAVVKANAY    50
    GHGSVELAKT FAENGADCFA VSSLDEAVEL RRYAHIDKEI FILGHTDARR 100
    TEELLTYDIE PAVFNLKNAE FFSQEAQRLG KTLRVHIAVD TGMSRVGFQV 150
    NEFSVSEIKA IAALPNIEIR GMFTHFAVSD IKDKTFTREQ YGHFRWMCKR 200
    MEEEGIHIAL RHCCNSAAAL ELPEYYCDMV RPGIIMYGCE PSPDVDIKPY 250
    DLRPVMSLRC CIAHVKLIDA GATVSYGRHY TAPSRRKIAT LPVGYADGYS 300
    RILSGKVDVL YHGHRVPQVG AICMDQCMID VSGEANVHAG DEVVLFGRQG 350
    DSFIPIEEIA AACGTINYEI MCDISRRVPR VYMKNGKVVG REEYLFDKP 399
    Length:399
    Mass (Da):44,739
    Last modified:October 19, 2011 - v1
    Checksum:i62E05F70386760BB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE576794 Genomic DNA. Translation: CCC73697.1.
    RefSeqiYP_004766524.1. NC_015873.1.

    Genome annotation databases

    EnsemblBacteriaiCCC73697; CCC73697; MELS_1476.
    GeneIDi11183414.
    KEGGimed:MELS_1476.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE576794 Genomic DNA. Translation: CCC73697.1 .
    RefSeqi YP_004766524.1. NC_015873.1.

    3D structure databases

    ProteinModelPortali G0VQJ7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCC73697 ; CCC73697 ; MELS_1476 .
    GeneIDi 11183414.
    KEGGi med:MELS_1476.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome Sequence of the Ruminal Bacterium Megasphaera elsdenii."
      Marx H., Graf A.B., Tatto N., Thallinger G.G., Mattanovich D., Sauer M.
      J. Bacteriol. 193:5578-5579(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiG0VQJ7_MEGEL
    AccessioniPrimary (citable) accession number: G0VQJ7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 19, 2011
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3