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Protein

Histone-lysine N-methyltransferase

Gene

NCAS0I02880

Organism
Naumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationSAAS annotation, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
Name:NCAS0I02880Imported
Ordered Locus Names:NCAS_0I02880Imported
OrganismiNaumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)Imported
Taxonomic identifieri1064592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNaumovozyma
Proteomesi
  • UP000001640 Componenti: Chromosome 9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi1064592.XP_003678298.1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 104AWSInterPro annotationAdd BLAST56
Domaini106 – 223SETInterPro annotationAdd BLAST118
Domaini230 – 246Post-SETInterPro annotationAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili364 – 384Sequence analysisAdd BLAST21
Coiled coili401 – 421Sequence analysisAdd BLAST21
Coiled coili585 – 631Sequence analysisAdd BLAST47

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4442 Eukaryota
COG2940 LUCA
InParanoidiG0VKC2
KOiK11423
OrthoDBiEOG092C3T9B

Family and domain databases

Gene3Di1.10.1740.100, 1 hit
InterProiView protein in InterPro
IPR006560 AWS_dom
IPR025788 Hist-Lys_N-MeTrfase_SET2_fun
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR013257 SRI
IPR038190 SRI_sf
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00856 SET, 1 hit
PF08236 SRI, 1 hit
SMARTiView protein in SMART
SM00570 AWS, 1 hit
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS51215 AWS, 1 hit
PS50868 POST_SET, 1 hit
PS51568 SAM_MT43_SET2_1, 1 hit
PS50280 SET, 1 hit

Sequencei

Sequence statusi: Complete.

G0VKC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSQQVHVND SIPKLFTNEE DKTDEVLATF TELKKCTYSS KKLGNSKNND
60 70 80 90 100
FIECDCYEDS TNGVNHACDE NSDCINRLTL IECVNDLCYS CGNDCQNQRF
110 120 130 140 150
QKSQYADISI FKTKMKGYGV RANADIETNE FIYEYTGEVI DEEIFRDRMI
160 170 180 190 200
EYDEKKFKHF YFMMLQNCEF IDATLKGSLA RFCNHSCNPN AYVNKWEVAG
210 220 230 240 250
KLRMGIFASR KIIKGEEITF DYNVDRYGAT AQKCYCEEPN CIGFLGGKTQ
260 270 280 290 300
TDAASLLPQS YADALGIKVS MEKEWIKKMK EIGVKIKKHA NDANNNVNID
310 320 330 340 350
FVESIDIQPC QTPDDVRKVM SVLLQVDNEY IALKLFHRLY SIEDEILLHQ
360 370 380 390 400
VIKLHGYICF AKLLKTFADE INTEEEILEL LERLPKTTKN GITSSQIDTQ
410 420 430 440 450
VSELSEEIPS LKEQCDMLLN KWDKYETYRR ITKKDISESS TNRMIDLRRI
460 470 480 490 500
RLPLGWEIIY ENGRPIYFNA QRQIKLNEPP TEEHNVMNEK TNNNNNDDDD
510 520 530 540 550
IKRHGGSVQS HDLLRNKRRR EHLDNFVKKQ KNGSKSDPWQ RSGSKSNDLI
560 570 580 590 600
DDPWRPRRGG SSNRSLDSSF QEEKKFSTPP QSSLEETVSK NNDELLRIIE
610 620 630 640 650
EANKQKEQER EEELQREREK EEKRLQRKSK SQVNVSEHKW NKFFASFVPN
660 670 680 690 700
LVRKNVVGVK LSHDHIKECS RDIVKILTSK ELKKDDAKSP PEDLTREKKK
710 720
KTNSFVKVYM EKFIEKYKSK KHSHKH
Length:726
Mass (Da):84,685
Last modified:October 19, 2011 - v1
Checksum:i98CC18A860C07C55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE576760 Genomic DNA Translation: CCC71956.1
RefSeqiXP_003678298.1, XM_003678250.1

Genome annotation databases

EnsemblFungiiCCC71956; CCC71956; NCAS_0I02880
GeneIDi11525407
KEGGincs:NCAS_0I02880

Similar proteinsi

Entry informationi

Entry nameiG0VKC2_NAUCC
AccessioniPrimary (citable) accession number: G0VKC2
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: March 28, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health