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G0VGI5

- G0VGI5_NAUCC

UniProt

G0VGI5 - G0VGI5_NAUCC

Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

NCAS0F01220

Organism
Naumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 17 (01 Oct 2014)
      Sequence version 1 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei471 – 4711S-adenosyl-L-methionineUniRule annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Alternative name(s):
    Histone H3-K79 methyltransferaseUniRule annotation
    Gene namesi
    Name:NCAS0F01220Imported
    Ordered Locus Names:NCAS_0F01220Imported
    OrganismiNaumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)Imported
    Taxonomic identifieri1064592 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNaumovozyma
    ProteomesiUP000001640: Chromosome 6

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni421 – 4244S-adenosyl-L-methionine bindingUniRule annotation
    Regioni444 – 45310S-adenosyl-L-methionine bindingUniRule annotation
    Regioni508 – 5092S-adenosyl-L-methionine bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation

    Phylogenomic databases

    KOiK11427.
    OrthoDBiEOG7KH9VN.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021162. Histone_H3-K79_MeTrfase_fungi.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF08123. DOT1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51569. DOT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G0VGI5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTNTVPFTP SPSSSSIFST STTNFNNNNS RDSSMAPADS TEASLTEQTK    50
    KGKTRAKGSS AVEKLLEEAN RYHPQYEYSL PQGFLRTRKS KAASPSEEQA 100
    SDLAKDDNLV KRKMEEEEDY DTSTTAAKKV RKNKVTSTSS TKKRKRKIKK 150
    AETNGTTGSK PTKKRKDTIK RPLSPSAALA DSVRRMSISA MLDDSDTKDG 200
    TGIYNEQGVK LDPVANKDDR AMTSTFLDWD QPYLELQYPL FNVDSLKLTN 250
    VYKGNPIKST ILTSLTHHQS RHKPPSLSND SSIKFVHLQS PLFVNYQEEY 300
    MINFEKDLQR YNPMSEIGKL IEYTALVYLP STYSEKLKRE VIPSLNQAFD 350
    NSDTDRFISS VERYNSIIRM VPRHEILEHL KTITQIPKSF IHDFLHIIYT 400
    RSIHPHASKL KHYKAFSNFV YGELLPNFLS EVFSQCNLKP NCTFMDLGSG 450
    VGNCVIQASL EYGLKKSFGC EIMPDASELT ELQMVELKER GKLFGFNLSD 500
    IEFSLRESFV DNPKVDELIK DCDLLLVNNF LFDSKLNEKV EKITQNLKTG 550
    CKIVSLKNLR SFSYKIDFFN MENILSRLKV EKVLLKEDSV SWTHSGGEYY 600
    IATVMENIDE SLFDPVVRGR NTRRPTKYSR 630
    Length:630
    Mass (Da):71,757
    Last modified:October 19, 2011 - v1
    Checksum:i8B0BC9ACFD232324
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE576757 Genomic DNA. Translation: CCC70606.1.
    RefSeqiXP_003676961.1. XM_003676913.1.

    Genome annotation databases

    GeneIDi11527634.
    KEGGincs:NCAS_0F01220.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE576757 Genomic DNA. Translation: CCC70606.1 .
    RefSeqi XP_003676961.1. XM_003676913.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 11527634.
    KEGGi ncs:NCAS_0F01220.

    Phylogenomic databases

    KOi K11427.
    OrthoDBi EOG7KH9VN.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021162. Histone_H3-K79_MeTrfase_fungi.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF08123. DOT1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51569. DOT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolutionary erosion of yeast sex chromosomes by mating-type switching accidents."
      Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P., Wolfe K.H.
      Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630Imported.
    2. "Genome sequence of Naumovozyma castellii."
      Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P., Wolfe K.H.
      Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Type strain:CBS 4309.

    Entry informationi

    Entry nameiG0VGI5_NAUCC
    AccessioniPrimary (citable) accession number: G0VGI5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 19, 2011
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 17 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3