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G0VGI5 (G0VGI5_NAUCC) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specific PIRNR PIRNR017570

EC=2.1.1.43 PIRNR PIRNR017570
Alternative name(s):
Histone H3-K79 methyltransferase PIRNR PIRNR017570
Gene names
Name:NCAS0F01220 EMBL CCC70606.1
Ordered Locus Names:NCAS_0F01220 EMBL CCC70606.1
OrganismNaumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii) [Complete proteome] EMBL CCC70606.1
Taxonomic identifier1064592 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNaumovozyma

Protein attributes

Sequence length630 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones By similarity. PIRNR PIRNR017570

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. PIRNR PIRNR017570

Subcellular location

Nucleus By similarity PIRNR PIRNR017570.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. PIRNR PIRNR017570

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region421 – 4244S-adenosyl-L-methionine binding By similarity PIRSR PIRSR017570-1
Region444 – 45310S-adenosyl-L-methionine binding By similarity PIRSR PIRSR017570-1
Region508 – 5092S-adenosyl-L-methionine binding By similarity PIRSR PIRSR017570-1

Sites

Binding site4711S-adenosyl-L-methionine By similarity PIRSR PIRSR017570-1

Sequences

Sequence LengthMass (Da)Tools
G0VGI5 [UniParc].

Last modified October 19, 2011. Version 1.
Checksum: 8B0BC9ACFD232324

FASTA63071,757
        10         20         30         40         50         60 
MTTNTVPFTP SPSSSSIFST STTNFNNNNS RDSSMAPADS TEASLTEQTK KGKTRAKGSS 

        70         80         90        100        110        120 
AVEKLLEEAN RYHPQYEYSL PQGFLRTRKS KAASPSEEQA SDLAKDDNLV KRKMEEEEDY 

       130        140        150        160        170        180 
DTSTTAAKKV RKNKVTSTSS TKKRKRKIKK AETNGTTGSK PTKKRKDTIK RPLSPSAALA 

       190        200        210        220        230        240 
DSVRRMSISA MLDDSDTKDG TGIYNEQGVK LDPVANKDDR AMTSTFLDWD QPYLELQYPL 

       250        260        270        280        290        300 
FNVDSLKLTN VYKGNPIKST ILTSLTHHQS RHKPPSLSND SSIKFVHLQS PLFVNYQEEY 

       310        320        330        340        350        360 
MINFEKDLQR YNPMSEIGKL IEYTALVYLP STYSEKLKRE VIPSLNQAFD NSDTDRFISS 

       370        380        390        400        410        420 
VERYNSIIRM VPRHEILEHL KTITQIPKSF IHDFLHIIYT RSIHPHASKL KHYKAFSNFV 

       430        440        450        460        470        480 
YGELLPNFLS EVFSQCNLKP NCTFMDLGSG VGNCVIQASL EYGLKKSFGC EIMPDASELT 

       490        500        510        520        530        540 
ELQMVELKER GKLFGFNLSD IEFSLRESFV DNPKVDELIK DCDLLLVNNF LFDSKLNEKV 

       550        560        570        580        590        600 
EKITQNLKTG CKIVSLKNLR SFSYKIDFFN MENILSRLKV EKVLLKEDSV SWTHSGGEYY 

       610        620        630 
IATVMENIDE SLFDPVVRGR NTRRPTKYSR 

« Hide

References

« Hide 'large scale' references
[1]"Evolutionary erosion of yeast sex chromosomes by mating-type switching accidents."
Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P., Wolfe K.H.
Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630.
[2]"Genome sequence of Naumovozyma castellii."
Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P., Wolfe K.H.
Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Type strain:CBS 4309.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE576757 Genomic DNA. Translation: CCC70606.1.
RefSeqXP_003676961.1. XM_003676913.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID11527634.
KEGGncs:NCAS_0F01220.

Phylogenomic databases

KOK11427.
OrthoDBEOG7KH9VN.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021162. Histone_H3-K79_MeTrfase_fungi.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMSSF53335. SSF53335. 1 hit.
PROSITEPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG0VGI5_NAUCC
AccessionPrimary (citable) accession number: G0VGI5
Entry history
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: June 11, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)