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Protein

Acyl-CoA desaturase

Gene

NCAS0D03250

Organism
Naumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Stearyl-CoA desaturase that utilizes O2 and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.UniRule annotation

Catalytic activityi

Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Expected to bind 2 Fe2+ ions per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
Biological processElectron transportUniRule annotation, Fatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Transport
LigandHemeUniRule annotationSAAS annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA desaturaseUniRule annotation (EC:1.14.19.1UniRule annotation)
Gene namesi
Name:NCAS0D03250Imported
Ordered Locus Names:NCAS_0D03250Imported
OrganismiNaumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)Imported
Taxonomic identifieri1064592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNaumovozyma
Proteomesi
  • UP000001640 Componenti: Chromosome 4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei96 – 114HelicalSequence analysisAdd BLAST19
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Transmembranei241 – 258HelicalSequence analysisAdd BLAST18
Transmembranei270 – 295HelicalSequence analysisAdd BLAST26

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi1064592.XP_003676267.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini396 – 474Cytochrome b5 heme-bindingInterPro annotationAdd BLAST79

Sequence similaritiesi

Belongs to the fatty acid desaturase type 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0537. Eukaryota.
KOG1600. Eukaryota.
COG1398. LUCA.
COG5274. LUCA.
InParanoidiG0VEB5.
KOiK00507.
OrthoDBiEOG092C2CE8.

Family and domain databases

CDDicd03505. Delta9-FADS-like. 1 hit.
Gene3Di3.10.120.10. 1 hit.
InterProiView protein in InterPro
IPR009160. Acyl-CoA_deSatase_haem/ster-bd.
IPR015876. Acyl-CoA_DS.
IPR001199. Cyt_B5-like_heme/steroid-bd.
IPR018506. Cyt_B5_heme-BS.
IPR005804. FA_desaturase_dom.
IPR001522. FADS-1_CS.
PANTHERiPTHR11351. PTHR11351. 1 hit.
PfamiView protein in Pfam
PF00173. Cyt-b5. 1 hit.
PF00487. FA_desaturase. 1 hit.
PIRSFiPIRSF000345. OLE1. 1 hit.
PRINTSiPR00075. FACDDSATRASE.
SMARTiView protein in SMART
SM01117. Cyt-b5. 1 hit.
SUPFAMiSSF55856. SSF55856. 1 hit.
PROSITEiView protein in PROSITE
PS00191. CYTOCHROME_B5_1. 1 hit.
PS50255. CYTOCHROME_B5_2. 1 hit.
PS00476. FATTY_ACID_DESATUR_1. 1 hit.

Sequencei

Sequence statusi: Complete.

G0VEB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPQITTRSS VEVATTPVLS NDIETVDLIE ANIVASGANK KTVRVVNGLG
60 70 80 90 100
SLMGSKEITQ LDDSITAKVQ PSTTTSGEKL HISEQPWTLN NWHQHINWLN
110 120 130 140 150
MVLTVFIPAI GFYFALSGKV PVRKNVVLFA LFYYVASGIT ITAGYHRLWS
160 170 180 190 200
HRAFEARWPL RLFFAILGAA NVQGSIKWWG HSHRIHHRYT DTPRDPYDAR
210 220 230 240 250
RGLWYSHMGW MLMKPNPKYK ARADISDLND DWIVRFQHRH YIPIMILTAF
260 270 280 290 300
VFPTWVVGKY ISPGDYMAGF IYAGILRVFA IQQATFCINS LAHFLGDQPF
310 320 330 340 350
DDKRTPRDNW ITALVTFGEG YHNFHHEFPT DYRNAIKWYQ YDPTKLFIYA
360 370 380 390 400
TSILGLALNL KTFDANVIQQ GIVQQQEKKV NKMKNKLHWG PTLDELPVWD
410 420 430 440 450
KKEFVEQAQL NKNLVVISGI IHDISNYIPE HPGGESLIKQ ALGKDATRAF
460 470 480 490
QGGVYRHSTA AQNVLSELRV AVLKENGNAA MNFVKRRGEQ FDKNKFE
Length:497
Mass (Da):56,733
Last modified:October 19, 2011 - v1
Checksum:i7812313D5C93FD2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE576755 Genomic DNA. Translation: CCC69906.1.
RefSeqiXP_003676267.1. XM_003676219.1.

Genome annotation databases

EnsemblFungiiCCC69906; CCC69906; NCAS_0D03250.
GeneIDi11528327.
KEGGincs:NCAS_0D03250.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiG0VEB5_NAUCC
AccessioniPrimary (citable) accession number: G0VEB5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: June 7, 2017
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported