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Protein

Glutamate decarboxylase

Gene

NCAS0C00660

Organism
Naumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Name:NCAS0C00660Imported
Ordered Locus Names:NCAS_0C00660Imported
OrganismiNaumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)Imported
Taxonomic identifieri1064592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNaumovozyma
ProteomesiUP000001640: Chromosome 3

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

InParanoidiG0VC49.
KOiK01580.
OrthoDBiEOG7P2Z22.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

G0VC49-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLYKHTNNQK NPRTLYPKKE EQEERIAAQT TQTRKSIVGL EDVKLLSSQL
60 70 80 90 100
QEMSYPGATT TLEQSQTTLA NSYVIPRHGL PEDVAYNLVH NELNLDGNPH
110 120 130 140 150
LNLASFVNTT TTDIANKLIN ENINKNLADN DEYPQLIELT QRCISMLAQL
160 170 180 190 200
WKCSPDLEPI GCATTGSSEA IMLGGLAMKK KWEHRMQDAG KDISKPNIIM
210 220 230 240 250
SSACQVALEK FARYFEVECR LVPVSKKSHY MLDPKSLWDY VDENTIGCFV
260 270 280 290 300
ILGTTYTGHL ENVEKVADVL TEIENQNPTW SNKDIPIHVD GASGGFIVPL
310 320 330 340 350
SFHTDHMKQY GLQRWGFNHP RVVSINTSSH KFGLTTPGLG WVLWKDDSYL
360 370 380 390 400
SNELRFRLKY LGGIEETFGL NFSRPGFQVV HQYFNFVSMG LNGYKALFKK
410 420 430 440 450
SIFVSRVFAH SLLTSKKMPG YFDIVSSTHE RISDGGIPDY VSDYWDNTQD
460 470 480 490 500
YKPGIPLVAF KLSDEFHENF PEIPQAMISS MLRSRGWIIP NYPLPKSTDD
510 520 530 540 550
SDQCEVLRVV FRSEMKLDLA QMLLIDIEGI ITKLLYSYTK VSKEAQHMQA
560 570 580 590
TPESRRSFIY EMLLALASPE EGDTETNPEL KERTSRNYRG TC
Length:592
Mass (Da):67,279
Last modified:October 19, 2011 - v1
Checksum:i1C1002F0227F8149
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE576754 Genomic DNA. Translation: CCC69056.1.
RefSeqiXP_003675425.1. XM_003675377.1.

Genome annotation databases

GeneIDi11528100.
KEGGincs:NCAS_0C00660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE576754 Genomic DNA. Translation: CCC69056.1.
RefSeqiXP_003675425.1. XM_003675377.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11528100.
KEGGincs:NCAS_0C00660.

Phylogenomic databases

InParanoidiG0VC49.
KOiK01580.
OrthoDBiEOG7P2Z22.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionary erosion of yeast sex chromosomes by mating-type switching accidents."
    Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P., Wolfe K.H.
    Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630Imported.
  2. "Genome sequence of Naumovozyma castellii."
    Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P., Wolfe K.H.
    Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Type strain:CBS 4309.

Entry informationi

Entry nameiG0VC49_NAUCC
AccessioniPrimary (citable) accession number: G0VC49
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: February 4, 2015
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.