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G0VA57

- G0VA57_NAUCC

UniProt

G0VA57 - G0VA57_NAUCC

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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

NCAS0B07030

Organism
Naumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Gene namesi
Name:NCAS0B07030Imported
Ordered Locus Names:NCAS_0B07030Imported
OrganismiNaumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)Imported
Taxonomic identifieri1064592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNaumovozyma
ProteomesiUP000001640: Chromosome 2

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. Set1C/COMPASS complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains SET domain.SAAS annotation
Contains post-SET domain.SAAS annotation

Phylogenomic databases

InParanoidiG0VA57.
KOiK11422.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G0VA57-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGYHRRSYP RPPSSSHRPH GSAPNHQGPP YQEEREPSRS RYNNDGQGSF
60 70 80 90 100
QETRYSGERE SIGHRYQQPP SRVYKDQKHP DSGRVPYAAR SIRRAIDEHA
110 120 130 140 150
NTRPQPFFPT RDSRYSQGNS SPTAHVPLKI AKSVSSAGKP VRSLHSRPAP
160 170 180 190 200
IIRYSEVTNL TAKYHYFDPV SKKLIHKDEM STWNQKGKYP ITGFVTILDS
210 220 230 240 250
EQHPMIQARN PEIKSIDPRK LTSPTASISH RKLRNNLTNV ARIVYDKYSV
260 270 280 290 300
GPPPPCAIIV SPTSIINNTM IQDISIKNYF KKFGVISHFE SFNDPNSALP
310 320 330 340 350
LHIYLIKYTA PNGKLSNLDI PVKSAYQAVK EFKEKGCFIM GSNFNVALNK
360 370 380 390 400
EKLLEDIKTT LVEENIKKAK QLSAVAISTE KKDRAPIAKN QKITMERPKR
410 420 430 440 450
SIPYDLARAV NNKPCLFVSR VFMALHGFRT EDFKYKLRRY RYSKFLDHIT
460 470 480 490 500
GLYIVFGDLL ECKKCFELES GKMTLVSRSR RIPIEIRFVL IPPVDQLPTR
510 520 530 540 550
FGGFGKSTNL SPSTSSASHV KVYKTKDELI NATVKYILKD LKSILDTDIR
560 570 580 590 600
KRLIGPTVFD TLNPTNFPEL MSKKESKERA KQNAIETAAV EQKKLRESTN
610 620 630 640 650
QDFDIFNLYG GYTRKAIKKR RTSELSDISE SISLKKKKLA RPMAHLLNED
660 670 680 690 700
IGSKENTPTL ESATPFDEFD NDHDLLSSTS SSEAEDGFID DKQKVLTNES
710 720 730 740 750
PVTTPETPQD DSLLFSSSKP PKVDVTADLY KPSATEFPET VYKEDLSILK
760 770 780 790 800
LSTPLSIVDL QNMVRDDEDL FLLKELVAYK EPNTVNAADE CLEYAIWKLR
810 820 830 840 850
EWKKNDTLIK ENQLKLNEVP FAPALKIKNG PFKAENIRKV PDRLKNCYLP
860 870 880 890 900
HRRKLHQPLN TVNQHNTESV DKENSPEKLS KREDTVKPEP SESVVAQEIS
910 920 930 940 950
SSRDNRASNR RFQQNIEAQR AAIGTESELL SLNQLNKRKK PVTFARSAIH
960 970 980 990 1000
NWGLYALEPI AAREMIIEYV GESIRQPVAE MRERRYLKSG IGSSYLFRVD
1010 1020 1030 1040 1050
ENNVIDATKK GGIARFINHC CDPSCTAKII KVGGKRRIVI YALRDIAANE
1060 1070 1080
ELTYDYKFER ELDAEERLPC YCGSVNCKGF LN
Length:1,082
Mass (Da):123,202
Last modified:October 19, 2011 - v1
Checksum:i8DBDE110CD02CA53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE576753 Genomic DNA. Translation: CCC68787.1.
RefSeqiXP_003675158.1. XM_003675110.1.

Genome annotation databases

GeneIDi11525032.
KEGGincs:NCAS_0B07030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE576753 Genomic DNA. Translation: CCC68787.1 .
RefSeqi XP_003675158.1. XM_003675110.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 11525032.
KEGGi ncs:NCAS_0B07030.

Phylogenomic databases

InParanoidi G0VA57.
KOi K11422.
OrthoDBi EOG7P8PH3.

Family and domain databases

InterProi IPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view ]
PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTi SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionary erosion of yeast sex chromosomes by mating-type switching accidents."
    Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P., Wolfe K.H.
    Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630Imported.
  2. "Genome sequence of Naumovozyma castellii."
    Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P., Wolfe K.H.
    Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Type strain:CBS 4309.

Entry informationi

Entry nameiG0VA57_NAUCC
AccessioniPrimary (citable) accession number: G0VA57
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: October 29, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3