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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

NCAS0B07030

Organism
Naumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationSAAS annotation, Transferase
LigandS-adenosyl-L-methionineUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Gene namesi
Name:NCAS0B07030Imported
Ordered Locus Names:NCAS_0B07030Imported
OrganismiNaumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)Imported
Taxonomic identifieri1064592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNaumovozyma
Proteomesi
  • UP000001640 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex.UniRule annotation

Protein-protein interaction databases

STRINGi1064592.XP_003675158.1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini940 – 1057SETInterPro annotationAdd BLAST118
Domaini1066 – 1082Post-SETInterPro annotationAdd BLAST17

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1080 Eukaryota
COG2940 LUCA
InParanoidiG0VA57
KOiK11422
OrthoDBiEOG092C3T9B

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR024657 COMPASS_Set1_N-SET
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR003616 Post-SET_dom
IPR017111 Set1
IPR024636 SET_assoc
IPR001214 SET_dom
PANTHERiPTHR22884:SF462 PTHR22884:SF462, 4 hits
PfamiView protein in Pfam
PF11764 N-SET, 1 hit
PF00856 SET, 1 hit
PF11767 SET_assoc, 1 hit
PIRSFiPIRSF037104 Histone_H3-K4_mtfrase_Set1_fun, 1 hit
SMARTiView protein in SMART
SM01291 N-SET, 1 hit
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit
PROSITEiView protein in PROSITE
PS50868 POST_SET, 1 hit
PS51572 SAM_MT43_1, 1 hit
PS50280 SET, 1 hit

Sequencei

Sequence statusi: Complete.

G0VA57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGYHRRSYP RPPSSSHRPH GSAPNHQGPP YQEEREPSRS RYNNDGQGSF
60 70 80 90 100
QETRYSGERE SIGHRYQQPP SRVYKDQKHP DSGRVPYAAR SIRRAIDEHA
110 120 130 140 150
NTRPQPFFPT RDSRYSQGNS SPTAHVPLKI AKSVSSAGKP VRSLHSRPAP
160 170 180 190 200
IIRYSEVTNL TAKYHYFDPV SKKLIHKDEM STWNQKGKYP ITGFVTILDS
210 220 230 240 250
EQHPMIQARN PEIKSIDPRK LTSPTASISH RKLRNNLTNV ARIVYDKYSV
260 270 280 290 300
GPPPPCAIIV SPTSIINNTM IQDISIKNYF KKFGVISHFE SFNDPNSALP
310 320 330 340 350
LHIYLIKYTA PNGKLSNLDI PVKSAYQAVK EFKEKGCFIM GSNFNVALNK
360 370 380 390 400
EKLLEDIKTT LVEENIKKAK QLSAVAISTE KKDRAPIAKN QKITMERPKR
410 420 430 440 450
SIPYDLARAV NNKPCLFVSR VFMALHGFRT EDFKYKLRRY RYSKFLDHIT
460 470 480 490 500
GLYIVFGDLL ECKKCFELES GKMTLVSRSR RIPIEIRFVL IPPVDQLPTR
510 520 530 540 550
FGGFGKSTNL SPSTSSASHV KVYKTKDELI NATVKYILKD LKSILDTDIR
560 570 580 590 600
KRLIGPTVFD TLNPTNFPEL MSKKESKERA KQNAIETAAV EQKKLRESTN
610 620 630 640 650
QDFDIFNLYG GYTRKAIKKR RTSELSDISE SISLKKKKLA RPMAHLLNED
660 670 680 690 700
IGSKENTPTL ESATPFDEFD NDHDLLSSTS SSEAEDGFID DKQKVLTNES
710 720 730 740 750
PVTTPETPQD DSLLFSSSKP PKVDVTADLY KPSATEFPET VYKEDLSILK
760 770 780 790 800
LSTPLSIVDL QNMVRDDEDL FLLKELVAYK EPNTVNAADE CLEYAIWKLR
810 820 830 840 850
EWKKNDTLIK ENQLKLNEVP FAPALKIKNG PFKAENIRKV PDRLKNCYLP
860 870 880 890 900
HRRKLHQPLN TVNQHNTESV DKENSPEKLS KREDTVKPEP SESVVAQEIS
910 920 930 940 950
SSRDNRASNR RFQQNIEAQR AAIGTESELL SLNQLNKRKK PVTFARSAIH
960 970 980 990 1000
NWGLYALEPI AAREMIIEYV GESIRQPVAE MRERRYLKSG IGSSYLFRVD
1010 1020 1030 1040 1050
ENNVIDATKK GGIARFINHC CDPSCTAKII KVGGKRRIVI YALRDIAANE
1060 1070 1080
ELTYDYKFER ELDAEERLPC YCGSVNCKGF LN
Length:1,082
Mass (Da):123,202
Last modified:October 19, 2011 - v1
Checksum:i8DBDE110CD02CA53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE576753 Genomic DNA Translation: CCC68787.1
RefSeqiXP_003675158.1, XM_003675110.1

Genome annotation databases

EnsemblFungiiCCC68787; CCC68787; NCAS_0B07030
GeneIDi11525032
KEGGincs:NCAS_0B07030

Similar proteinsi

Entry informationi

Entry nameiG0VA57_NAUCC
AccessioniPrimary (citable) accession number: G0VA57
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: March 28, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health