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G0VA57

- G0VA57_NAUCC

UniProt

G0VA57 - G0VA57_NAUCC

Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

NCAS0B07030

Organism
Naumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationSAAS annotation, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Gene namesi
    Name:NCAS0B07030Imported
    Ordered Locus Names:NCAS_0B07030Imported
    OrganismiNaumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)Imported
    Taxonomic identifieri1064592 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNaumovozyma
    ProteomesiUP000001640: Chromosome 2

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-KW
    2. Set1C/COMPASS complex Source: InterPro

    Keywords - Cellular componenti

    ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Component of the COMPASS (Set1C) complex.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SET domain.UniRule annotation
    Contains SET domain.SAAS annotation
    Contains post-SET domain.SAAS annotation

    Phylogenomic databases

    KOiK11422.
    OrthoDBiEOG7P8PH3.

    Family and domain databases

    InterProiIPR024657. COMPASS_Set1_N-SET.
    IPR017111. Hist_H3-K4_MeTrfase_1_fun.
    IPR003616. Post-SET_dom.
    IPR024636. SET_assoc.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF11764. N-SET. 1 hit.
    PF00856. SET. 1 hit.
    PF11767. SET_assoc. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
    SMARTiSM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS50868. POST_SET. 1 hit.
    PS51572. SAM_MT43_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G0VA57-1 [UniParc]FASTAAdd to Basket

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    MSGYHRRSYP RPPSSSHRPH GSAPNHQGPP YQEEREPSRS RYNNDGQGSF     50
    QETRYSGERE SIGHRYQQPP SRVYKDQKHP DSGRVPYAAR SIRRAIDEHA 100
    NTRPQPFFPT RDSRYSQGNS SPTAHVPLKI AKSVSSAGKP VRSLHSRPAP 150
    IIRYSEVTNL TAKYHYFDPV SKKLIHKDEM STWNQKGKYP ITGFVTILDS 200
    EQHPMIQARN PEIKSIDPRK LTSPTASISH RKLRNNLTNV ARIVYDKYSV 250
    GPPPPCAIIV SPTSIINNTM IQDISIKNYF KKFGVISHFE SFNDPNSALP 300
    LHIYLIKYTA PNGKLSNLDI PVKSAYQAVK EFKEKGCFIM GSNFNVALNK 350
    EKLLEDIKTT LVEENIKKAK QLSAVAISTE KKDRAPIAKN QKITMERPKR 400
    SIPYDLARAV NNKPCLFVSR VFMALHGFRT EDFKYKLRRY RYSKFLDHIT 450
    GLYIVFGDLL ECKKCFELES GKMTLVSRSR RIPIEIRFVL IPPVDQLPTR 500
    FGGFGKSTNL SPSTSSASHV KVYKTKDELI NATVKYILKD LKSILDTDIR 550
    KRLIGPTVFD TLNPTNFPEL MSKKESKERA KQNAIETAAV EQKKLRESTN 600
    QDFDIFNLYG GYTRKAIKKR RTSELSDISE SISLKKKKLA RPMAHLLNED 650
    IGSKENTPTL ESATPFDEFD NDHDLLSSTS SSEAEDGFID DKQKVLTNES 700
    PVTTPETPQD DSLLFSSSKP PKVDVTADLY KPSATEFPET VYKEDLSILK 750
    LSTPLSIVDL QNMVRDDEDL FLLKELVAYK EPNTVNAADE CLEYAIWKLR 800
    EWKKNDTLIK ENQLKLNEVP FAPALKIKNG PFKAENIRKV PDRLKNCYLP 850
    HRRKLHQPLN TVNQHNTESV DKENSPEKLS KREDTVKPEP SESVVAQEIS 900
    SSRDNRASNR RFQQNIEAQR AAIGTESELL SLNQLNKRKK PVTFARSAIH 950
    NWGLYALEPI AAREMIIEYV GESIRQPVAE MRERRYLKSG IGSSYLFRVD 1000
    ENNVIDATKK GGIARFINHC CDPSCTAKII KVGGKRRIVI YALRDIAANE 1050
    ELTYDYKFER ELDAEERLPC YCGSVNCKGF LN 1082
    Length:1,082
    Mass (Da):123,202
    Last modified:October 19, 2011 - v1
    Checksum:i8DBDE110CD02CA53
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE576753 Genomic DNA. Translation: CCC68787.1.
    RefSeqiXP_003675158.1. XM_003675110.1.

    Genome annotation databases

    GeneIDi11525032.
    KEGGincs:NCAS_0B07030.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE576753 Genomic DNA. Translation: CCC68787.1 .
    RefSeqi XP_003675158.1. XM_003675110.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 11525032.
    KEGGi ncs:NCAS_0B07030.

    Phylogenomic databases

    KOi K11422.
    OrthoDBi EOG7P8PH3.

    Family and domain databases

    InterProi IPR024657. COMPASS_Set1_N-SET.
    IPR017111. Hist_H3-K4_MeTrfase_1_fun.
    IPR003616. Post-SET_dom.
    IPR024636. SET_assoc.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF11764. N-SET. 1 hit.
    PF00856. SET. 1 hit.
    PF11767. SET_assoc. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
    SMARTi SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS50868. POST_SET. 1 hit.
    PS51572. SAM_MT43_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolutionary erosion of yeast sex chromosomes by mating-type switching accidents."
      Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P., Wolfe K.H.
      Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630Imported.
    2. "Genome sequence of Naumovozyma castellii."
      Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P., Wolfe K.H.
      Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Type strain:CBS 4309.

    Entry informationi

    Entry nameiG0VA57_NAUCC
    AccessioniPrimary (citable) accession number: G0VA57
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 19, 2011
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3