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Protein

Protein-S-isoprenylcysteine O-methyltransferase

Gene

NCAS0A12100

Organism
Naumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferaseUniRule annotation, Transferase
LigandS-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-S-isoprenylcysteine O-methyltransferaseUniRule annotation (EC:2.1.1.100UniRule annotation)
Gene namesi
Name:NCAS0A12100Imported
Ordered Locus Names:NCAS_0A12100Imported
OrganismiNaumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)Imported
Taxonomic identifieri1064592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNaumovozyma
Proteomesi
  • UP000001640 Componenti: Chromosome 1

Subcellular locationi

  • Endoplasmic reticulum membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 51HelicalUniRule annotationAdd BLAST20
Transmembranei58 – 75HelicalUniRule annotationAdd BLAST18
Transmembranei95 – 112HelicalUniRule annotationAdd BLAST18
Transmembranei124 – 144HelicalUniRule annotationAdd BLAST21
Transmembranei183 – 211HelicalUniRule annotationAdd BLAST29

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

Interactioni

Protein-protein interaction databases

STRINGi1064592.XP_003674149.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG2628. Eukaryota.
COG2020. LUCA.
InParanoidiG0V8H0.
KOiK00587.
OrthoDBiEOG092C5DVA.

Family and domain databases

InterProiView protein in InterPro
IPR007269. ICMT_MeTrfase.
IPR025770. PPMT_MeTrfase.
PfamiView protein in Pfam
PF04140. ICMT. 1 hit.
PROSITEiView protein in PROSITE
PS51564. SAM_ICMT. 1 hit.

Sequencei

Sequence statusi: Complete.

G0V8H0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVETEGETDV PYVNDSKTYP EITQNPLDEI SLTAYALGGL GGLFLGLIPV
60 70 80 90 100
LKFTNFNIYM IAFSLFHFLE FYTTAKYNPS KVSSDSFILN NGIEYTAAHL
110 120 130 140 150
LGVFECFIEG YFFKSSKALT PVKIVISCIA IMLIIIGQLT RSIAMCTAGK
160 170 180 190 200
SFSHFIKTEK ETDHVLVKDG IYAYLRHPSY FGFYWWAVGT QLLLLNPIST
210 220 230 240
VVFLYVLWAF FRKRINIEER YLISFFGKDY VQYKKEVSTR IPFIE
Length:245
Mass (Da):28,071
Last modified:October 19, 2011 - v1
Checksum:iD843462A1FE9B89A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE576752 Genomic DNA. Translation: CCC67768.1.
RefSeqiXP_003674149.1. XM_003674101.1.

Genome annotation databases

EnsemblFungiiCCC67768; CCC67768; NCAS_0A12100.
GeneIDi11524714.
KEGGincs:NCAS_0A12100.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiG0V8H0_NAUCC
AccessioniPrimary (citable) accession number: G0V8H0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: June 7, 2017
This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported