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Protein

Lysophospholipase NTE1

Gene

NCAS0A02850

Organism
Naumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis.UniRule annotation

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1347NucleophilePROSITE-ProRule annotation1
Active sitei1465Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolasePROSITE-ProRule annotation
Biological processLipid degradationPROSITE-ProRule annotation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1UniRule annotation (EC:3.1.1.5UniRule annotation)
Alternative name(s):
Intracellular phospholipase BUniRule annotation
Gene namesi
Name:NCAS0A02850Imported
Ordered Locus Names:NCAS_0A02850Imported
OrganismiNaumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)Imported
Taxonomic identifieri1064592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNaumovozyma
Proteomesi
  • UP000001640 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 58HelicalUniRule annotationAdd BLAST18
Transmembranei67 – 85HelicalUniRule annotationAdd BLAST19
Transmembranei91 – 114HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

Interactioni

Protein-protein interaction databases

STRINGi1064592.XP_003673234.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini743 – 859Cyclic nucleotide-bindingInterPro annotationAdd BLAST117
Domaini873 – 1017Cyclic nucleotide-bindingInterPro annotationAdd BLAST145
Domaini1314 – 1478PNPLAInterPro annotationAdd BLAST165

Sequence similaritiesi

Belongs to the NTE family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG2968. Eukaryota.
COG0664. LUCA.
COG1752. LUCA.
InParanoidiG0V5V5.
KOiK14676.
OrthoDBiEOG092C0BAH.

Family and domain databases

CDDicd00038. CAP_ED. 2 hits.
Gene3Di2.60.120.10. 3 hits.
InterProiView protein in InterPro
IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. PNPLA_dom.
IPR014710. RmlC-like_jellyroll.
PfamiView protein in Pfam
PF00027. cNMP_binding. 1 hit.
PF01734. Patatin. 1 hit.
SMARTiView protein in SMART
SM00100. cNMP. 1 hit.
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiView protein in PROSITE
PS50042. CNMP_BINDING_3. 2 hits.
PS51635. PNPLA. 1 hit.
PS01237. UPF0028. 1 hit.

Sequencei

Sequence statusi: Complete.

G0V5V5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTNKNSFN QSVDNQENNT IPSDGPSAGL PEQLITQNQD WLLSSIANFT
60 70 80 90 100
WIIMYFFMGT TMSLMRAIWY MITIVILRSS TWILFSTNKL QFTVSLSVFI
110 120 130 140 150
VMSAIIVYIT YCVVRARILS QYKKLTPDND DFVMNQNNIH SGLSDSATQR
160 170 180 190 200
DHMHYKNERK SSNQEDDTFL SSYLDQFLSA IKIFGYLEKP VFHDLTKNMK
210 220 230 240 250
TQKLDEGEIL LLDNSIGFAI VVEGTLQVYH EVEEKSSEPM VMDTTNHVGF
260 270 280 290 300
MSSSETNAKG DDGLSNSQVI SDTADDSSIE TDGDDDDDDD DDDDSDEELG
310 320 330 340 350
YIRLKNGLGR FQLLNTVKPG NPVSSLVNIL NLFTTAANND LFNANIIKKN
360 370 380 390 400
RGDSNELNLT LRKFIIDADK NDNNIPFDAT PPPPLLSQQS PSLSPSNNNL
410 420 430 440 450
PDVSLSDSMP KVVGVAATDC TIAIIPPQAF AKLTAKYPRS ASHIIQMILT
460 470 480 490 500
KLYNVTLQTA HNYLGLTKEI MNIELTLNKS VNYEIPYYLK EAVMRKFSNK
510 520 530 540 550
DKPIVNERKS YETSMPNFEK RPSSFDIPSS PTSKQSSNLN LKSPVASKSN
560 570 580 590 600
RNSIILGSRH VVLDSRDHFN PGDLLSNVPL SRKETMNEIS TRRRKSPLQK
610 620 630 640 650
SSHHALSAAF IEKEVPKRPN LKNKDTSTDF REIRKQTNNI IDRSFSSIQE
660 670 680 690 700
ETEESAVRMA IVEALFGFLG INKDNMSLYQ TNTNQSNGNF PNTHRSSEIS
710 720 730 740 750
LVTSFESSST PRTTLRILPS HYTIQTKKQM KKNKNKKTYK EEVFSNLDFE
760 770 780 790 800
SAKSSFMQGI KLQFFKQGTR IVEQNSNGKG MFYVIAGKID VTTTNEDELQ
810 820 830 840 850
VLSSGSKQKK QLEHHLFTVS NGGIAGYLSS VIGYKSFVNL NARTDVYVGF
860 870 880 890 900
LPNDTLENLC DKYFLIYLRI AETLTSMLST KLLKLDHALE WIHLTASETL
910 920 930 940 950
FKQGDPANGI YVVLNGRLRQ LQDHRHENND INKTIKRQQE GQGSVRNDDE
960 970 980 990 1000
TYEVILGEHA QGESFGEVEV LTAMDRISTI VAVRDSELVR IPRTLFELLA
1010 1020 1030 1040 1050
LEHPSIMIRV SRLVARKILS NNSSEVNQNP LASTSKFNLT IPTANSLITS
1060 1070 1080 1090 1100
NSYNGKQNTT SGSITFRTIT ILPIREGLPV ELFAMKLVQA FKQVGRTTIG
1110 1120 1130 1140 1150
LNQRTTLTHL GRHAFDRLAK LKQSGYFAEL EEMFQTVVYI ADTPSQSSWT
1160 1170 1180 1190 1200
KTCIAQGDCI LLLADANSSP DIGEFENLVL KSKTTARTGL ILLHPERYVE
1210 1220 1230 1240 1250
PGLTQKWLRY RPWVHSHHHI QMAVNSLESI SVLKTSGLNG GALALMDKLI
1260 1270 1280 1290 1300
QTEFSRKTQQ NISRLLPDSI KSKVENFSGR FMRRRNKQFY TPTHMHKNDF
1310 1320 1330 1340 1350
LRLARILSGQ AIGLVLGGGG ARGLSHLGMI QAIEEQGIPI DMIGGTSMGS
1360 1370 1380 1390 1400
FVGGLYAKDY DLVPIYGRVK KFAGRLSSIW RTLSDLTWPV TSYTTGHEFN
1410 1420 1430 1440 1450
RGIWKTFGET RIEDFWIQYY CNSTNITDSV QEIHSFGYAW RYIRASMSLA
1460 1470 1480 1490 1500
GLLPPLEENG SMLLDGGYLD NLPVSEMKLR GCNTIFAVDV GSVDDRTPMK
1510 1520 1530 1540 1550
YGDSLNGFWI VFNRWNPFST HPNIPNMAEI QVRLGYVASV NALENAKNTP
1560 1570 1580 1590 1600
GVIYIRPPID NYATLDFGKF EEIYGVGVDY GRVFFQELET EGNMPKLPGC
1610 1620
QNDYFDTKVS ELLLHRRNSI
Length:1,620
Mass (Da):182,232
Last modified:October 19, 2011 - v1
Checksum:iD4AE130BD8CD2AA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE576752 Genomic DNA. Translation: CCC66843.1.
RefSeqiXP_003673234.1. XM_003673186.1.

Genome annotation databases

EnsemblFungiiCCC66843; CCC66843; NCAS_0A02850.
GeneIDi11526605.
KEGGincs:NCAS_0A02850.

Similar proteinsi

Entry informationi

Entry nameiG0V5V5_NAUCC
AccessioniPrimary (citable) accession number: G0V5V5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: October 25, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported