G0TNP0 (G0TNP0_MYCCP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative [NAD] dependent malate oxidoreductase MEZ (Malic enzyme) (NAD-malic enzyme) (Malate dehydrogenase (Oxaloacetate decarboxylating)) (Pyruvic-malic carboxylase) (NAD-ME) EMBL CCC44695.1

Gene names

Name:	mez EMBL CCC44695.1
Ordered Locus Names:	MCAN_23641 EMBL CCC44695.1

Organism

Mycobacterium canettii (strain CIPT 140010059) [Complete proteome] [HAMAP] EMBL CCC44695.1

Taxonomic identifier

1048245 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › Mycobacterium canettii

Protein attributes

Sequence length	548 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor	Divalent metal cations. Prefers magnesium or manganese By similarity. PIRSR PIRSR000106-3
Sequence similarities	Belongs to the malic enzymes family. RuleBase RU003427

Ontologies

Keywords
Ligand	Metal-binding RuleBase RU003427 PIRSR PIRSR000106-3
Molecular function	Oxidoreductase RuleBase RU003427
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	malate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	NAD binding Inferred from electronic annotation. Source: InterPro malate dehydrogenase (oxaloacetate-decarboxylating) activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	96	1	Proton donor By similarity PIRSR PIRSR000106-1
	Active site	169	1	Proton acceptor By similarity PIRSR PIRSR000106-1
	Metal binding	240	1	Divalent metal cation By similarity PIRSR PIRSR000106-3
	Metal binding	241	1	Divalent metal cation By similarity PIRSR PIRSR000106-3
	Metal binding	264	1	Divalent metal cation By similarity PIRSR PIRSR000106-3

Sequences

	Sequence		Length	Mass (Da)
	G0TNP0 [UniParc]. Last modified October 19, 2011. Version 1. Checksum: 2E1EAE3007390653	FASTA	548	59,409
	10 20 30 40 50 60 MSDARVPRIP AALSAPSLNR GVGFTHAQRR RLGLTGRLPS AVLTLDQQAE RVWHQLQSLA 70 80 90 100 110 120 TDLGRNLLLE QLHYRHEVLY FKVLADHLPE LMPVVYTPTV GEAIQRFSDE YRGQRGLFLS 130 140 150 160 170 180 IDEPDEIEEA FNTLGLGPED VDLIVCTDAE AILGIGDWGV GGIQIAVGKL ALYTAGGGVD 190 200 210 220 230 240 PRRCLAVSLD VGTDNEQLLA DPFYLGNRHA RRRGREYDEF VSRYIETAQR LFPRAILHFE 250 260 270 280 290 300 DFGPANARKI LDTYGTDYCV FNDDMQGTGA VVLAAVYSGL KVTGIPLRDQ TIVVFGAGTA 310 320 330 340 350 360 GMGIADQIRD AMVADGATLE QAVSQIWPID RPGLLFDDMD DLRDFQVPYA KNRHQLGVAV 370 380 390 400 410 420 GDRVGLSDAI KIASPTILLG CSTVYGAFTK EVVEAMTASC KHPMIFPLSN PTSRMEAIPA 430 440 450 460 470 480 DVLAWSNGRA LLATGSPVAP VEFDETTYVI GQANNVLAFP GIGLGVIVAG ARLITRRMLH 490 500 510 520 530 540 AAAKAIAHQA NPTNPGDSLL PDVQNLRAIS TTVAEAVYRA AVQDGVASRT HDDVRQAIVD TMWLPAYD

References

[1]

"Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis." Supply P., Marceau M., Mangenot S., Roche D., Rouanet C., Khanna V., Majlessi L., Criscuolo A., Tap J., Pawlik A., Fiette L., Orgeur M., Fabre M., Parmentier C., Frigui W., Simeone R., Boritsch E.C., Debrie A.S. , Willery E., Walker D., Quail M.A., Ma L., Bouchier C., Salvignol G., Sayes F., Cascioferro A., Seemann T., Barbe V., Locht C., Gutierrez M.C., Leclerc C., Bentley S.D., Stinear T.P., Brisse S., Medigue C., Parkhill J., Cruveiller S., Brosch R. Nat. Genet. 45:172-179(2013) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CIPT 140010059 EMBL CCC44695.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	HE572590 Genomic DNA. Translation: CCC44695.1.
RefSeq	YP_004745795.1. NC_015848.1.
3D structure databases
ProteinModelPortal	G0TNP0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CCC44695; CCC44695; MCAN_23641.
GeneID	10984694.
KEGG	mce:MCAN_23641.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K00027.
Enzyme and pathway databases
BioCyc	MCAN1048245:GJCJ-2382-MONOMER.
Family and domain databases
Gene3D	3.40.50.10380. 1 hit. 3.40.50.720. 1 hit.
InterPro	IPR015884. Malic_enzyme_CS. IPR012301. Malic_N. IPR012302. Malic_NAD-bd. IPR001891. Malic_OxRdtase. IPR016040. NAD(P)-bd_dom. [Graphical view]
Pfam	PF00390. malic. 1 hit. PF03949. Malic_M. 1 hit. [Graphical view]
PIRSF	PIRSF000106. ME. 1 hit.
PRINTS	PR00072. MALOXRDTASE.
SMART	SM00919. Malic_M. 1 hit. [Graphical view]
PROSITE	PS00331. MALIC_ENZYMES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G0TNP0_MYCCP

Accession

Primary (citable) accession number: G0TNP0

Entry history

Integrated into UniProtKB/TrEMBL:	October 19, 2011
Last sequence update:	October 19, 2011
Last modified:	April 3, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)