G0THN8 (G0THN8_MYCCP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
2-phospho-L-lactate transferase HAMAP-Rule MF_01257
EC=2.7.8.28 HAMAP-Rule MF_01257

Alternative name(s):
LPPG:FO 2-phospho-L-lactate transferase HAMAP-Rule MF_01257

Gene names

Name:	fbiA EMBL CCC45611.1
Synonyms:	cofD HAMAP-Rule MF_01257
Ordered Locus Names:	MCAN_32801 EMBL CCC45611.1

Organism

Mycobacterium canettii (strain CIPT 140010059) [Complete proteome] [HAMAP] EMBL CCC45611.1

Taxonomic identifier

1048245 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › Mycobacterium canettii

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP By similarity. HAMAP-Rule MF_01257
Catalytic activity	(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = guanosine 5'-phosphate + coenzyme F420-0. HAMAP-Rule MF_01257
Cofactor	Magnesium By similarity. HAMAP-Rule MF_01257
Pathway	Cofactor biosynthesis; coenzyme F420 biosynthesis. HAMAP-Rule MF_01257
Subunit structure	Homodimer By similarity. HAMAP-Rule MF_01257
Sequence similarities	Belongs to the CofD family. HAMAP-Rule MF_01257

Ontologies

Keywords
Ligand	Magnesium HAMAP-Rule MF_01257
Molecular function	Transferase HAMAP-Rule MF_01257
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	coenzyme biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	magnesium ion binding Inferred from electronic annotation. Source: InterPro phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: HAMAP phosphotransferase activity, for other substituted phosphate groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	G0THN8 [UniParc]. Last modified October 19, 2011. Version 1. Checksum: 4D144F9A17F792C6	FASTA	331	35,335
	10 20 30 40 50 60 MKVTVLAGGV GGARFLLGVQ QLLGLGQFAA NSAHSDADHQ LSAVVNVGDD AWIHGLRVCP 70 80 90 100 110 120 DLDTCMYTLG GGVDPQRGWG QRDETWHAMQ ELVRYGVQPD WFELGDRDLA THLVRTQMLQ 130 140 150 160 170 180 AGYPLSQITE ALCDRWQPGA RLLPATDDRC ETHVVITDPV DESRKAIHFQ EWWVRYRAQV 190 200 210 220 230 240 PTHSFAFVGA EKSSAATEAI AALADADIIM LAPSNPVVSI GAILAVPGIR AALREATAPI 250 260 270 280 290 300 VGYSPIIGEK PLRGMADTCL SVIGVDSTAA AVGRHYGARC ATGILDCWLV HDGDHAEIDG 310 320 330 VTVRSVPLLM TDPNATAEMV RAGCDLAGVV A

References

[1]

"Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis." Supply P., Marceau M., Mangenot S., Roche D., Rouanet C., Khanna V., Majlessi L., Criscuolo A., Tap J., Pawlik A., Fiette L., Orgeur M., Fabre M., Parmentier C., Frigui W., Simeone R., Boritsch E.C., Debrie A.S. , Willery E., Walker D., Quail M.A., Ma L., Bouchier C., Salvignol G., Sayes F., Cascioferro A., Seemann T., Barbe V., Locht C., Gutierrez M.C., Leclerc C., Bentley S.D., Stinear T.P., Brisse S., Medigue C., Parkhill J., Cruveiller S., Brosch R. Nat. Genet. 45:172-179(2013) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CIPT 140010059 EMBL CCC45611.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	HE572590 Genomic DNA. Translation: CCC45611.1.
RefSeq	YP_004746691.1. NC_015848.1.
3D structure databases
ProteinModelPortal	G0THN8.
SMR	G0THN8. Positions 5-297.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CCC45611; CCC45611; MCAN_32801.
GeneID	10987268.
KEGG	mce:MCAN_32801.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K11212.
Enzyme and pathway databases
BioCyc	MCAN1048245:GJCJ-3313-MONOMER.
UniPathway	UPA00071.
Family and domain databases
HAMAP	MF_01257. CofD.
InterPro	IPR002882. CofD/UPF0052. IPR010115. LPPG-Fo_P-lactate_Trfase. [Graphical view]
Pfam	PF01933. UPF0052. 1 hit. [Graphical view]
TIGRFAMs	TIGR01819. F420_cofD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

G0THN8_MYCCP

Accession

Primary (citable) accession number: G0THN8

Entry history

Integrated into UniProtKB/TrEMBL:	October 19, 2011
Last sequence update:	October 19, 2011
Last modified:	May 1, 2013
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)