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Protein

2-phospho-L-lactate transferase

Gene

fbiA

Organism
Mycobacterium canettii (strain CIPT 140010059)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP.UniRule annotation

Catalytic activityi

(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = guanosine 5'-phosphate + coenzyme F420-0.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathway:icoenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation

Enzyme and pathway databases

BioCyciMCAN1048245:GJCJ-3313-MONOMER.
UniPathwayiUPA00071.

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate transferaseUniRule annotation (EC:2.7.8.28UniRule annotation)
Alternative name(s):
LPPG:FO 2-phospho-L-lactate transferaseUniRule annotation
Gene namesi
Name:fbiAImported
Synonyms:cofDUniRule annotation
Ordered Locus Names:MCAN_32801Imported
OrganismiMycobacterium canettii (strain CIPT 140010059)Imported
Taxonomic identifieri1048245 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000008896 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliG0THN8.
SMRiG0THN8. Positions 5-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofD family.UniRule annotation

Phylogenomic databases

KOiK11212.
OMAiHFQEYWV.

Family and domain databases

HAMAPiMF_01257. CofD.
InterProiIPR002882. CofD/UPF0052.
IPR010115. P-lactate_Trfase.
[Graphical view]
PfamiPF01933. UPF0052. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01819. F420_cofD. 1 hit.

Sequencei

Sequence statusi: Complete.

G0THN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVTVLAGGV GGARFLLGVQ QLLGLGQFAA NSAHSDADHQ LSAVVNVGDD
60 70 80 90 100
AWIHGLRVCP DLDTCMYTLG GGVDPQRGWG QRDETWHAMQ ELVRYGVQPD
110 120 130 140 150
WFELGDRDLA THLVRTQMLQ AGYPLSQITE ALCDRWQPGA RLLPATDDRC
160 170 180 190 200
ETHVVITDPV DESRKAIHFQ EWWVRYRAQV PTHSFAFVGA EKSSAATEAI
210 220 230 240 250
AALADADIIM LAPSNPVVSI GAILAVPGIR AALREATAPI VGYSPIIGEK
260 270 280 290 300
PLRGMADTCL SVIGVDSTAA AVGRHYGARC ATGILDCWLV HDGDHAEIDG
310 320 330
VTVRSVPLLM TDPNATAEMV RAGCDLAGVV A
Length:331
Mass (Da):35,335
Last modified:October 19, 2011 - v1
Checksum:i4D144F9A17F792C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE572590 Genomic DNA. Translation: CCC45611.1.
RefSeqiWP_003417087.1. NC_015848.1.

Genome annotation databases

EnsemblBacteriaiCCC45611; CCC45611; MCAN_32801.
KEGGimce:MCAN_32801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE572590 Genomic DNA. Translation: CCC45611.1.
RefSeqiWP_003417087.1. NC_015848.1.

3D structure databases

ProteinModelPortaliG0THN8.
SMRiG0THN8. Positions 5-297.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCC45611; CCC45611; MCAN_32801.
KEGGimce:MCAN_32801.

Phylogenomic databases

KOiK11212.
OMAiHFQEYWV.

Enzyme and pathway databases

UniPathwayiUPA00071.
BioCyciMCAN1048245:GJCJ-3313-MONOMER.

Family and domain databases

HAMAPiMF_01257. CofD.
InterProiIPR002882. CofD/UPF0052.
IPR010115. P-lactate_Trfase.
[Graphical view]
PfamiPF01933. UPF0052. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01819. F420_cofD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The Genome of Mycobacterium Africanum West African 2 Reveals a Lineage-Specific Locus and Genome Erosion Common to the M. tuberculosis Complex."
    Bentley S.D., Comas I., Bryant J.M., Walker D., Smith N.H., Harris S.R., Thurston S., Gagneux S., Wood J., Antonio M., Quail M.A., Gehre F., Adegbola R.A., Parkhill J., de Jong B.C.
    PLoS Negl. Trop. Dis. 6:e1552-e1552(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CIPT 140010059Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CIPT 140010059Imported.

Entry informationi

Entry nameiG0THN8_MYCCP
AccessioniPrimary (citable) accession number: G0THN8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: July 22, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.