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Protein

Riboflavin biosynthesis protein

Gene

ribF

Organism
Mycobacterium canettii (strain CIPT 140010059)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + FMN = diphosphate + FAD.UniRule annotation
ATP + riboflavin = ADP + FMN.UniRule annotation

Pathwayi: FAD biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes FAD from FMN.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Riboflavin biosynthesis protein (ribF)
This subpathway is part of the pathway FAD biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes FAD from FMN, the pathway FAD biosynthesis and in Cofactor biosynthesis.

Pathwayi: FMN biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes FMN from riboflavin (ATP route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Riboflavin biosynthesis protein (ribF)
This subpathway is part of the pathway FMN biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes FMN from riboflavin (ATP route), the pathway FMN biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotation, NucleotidyltransferaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, FADUniRule annotation, Flavoprotein, FMNUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00276; UER00406
UPA00277; UER00407

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin biosynthesis proteinUniRule annotation
Including the following 2 domains:
Riboflavin kinaseUniRule annotation (EC:2.7.1.26UniRule annotation)
Alternative name(s):
FlavokinaseUniRule annotation
FMN adenylyltransferaseUniRule annotation (EC:2.7.7.2UniRule annotation)
Alternative name(s):
FAD pyrophosphorylaseUniRule annotation
FAD synthaseUniRule annotation
Gene namesi
Name:ribFImported
Ordered Locus Names:MCAN_28141Imported
OrganismiMycobacterium canettii (strain CIPT 140010059)Imported
Taxonomic identifieri1048245 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000008896 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini194 – 329FlavokinaseInterPro annotationAdd BLAST136

Sequence similaritiesi

Belongs to the ribF family.UniRule annotation

Phylogenomic databases

KOiK11753
OMAiHRGHQAI

Family and domain databases

Gene3Di2.40.30.30, 1 hit
3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR015864 FAD_synthase
IPR023468 Riboflavin_kinase
IPR002606 Riboflavin_kinase_bac
IPR015865 Riboflavin_kinase_bac/euk
IPR023465 Riboflavin_kinase_dom_sf
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR22749 PTHR22749, 1 hit
PfamiView protein in Pfam
PF06574 FAD_syn, 1 hit
PF01687 Flavokinase, 1 hit
PIRSFiPIRSF004491 FAD_Synth, 1 hit
SMARTiView protein in SMART
SM00904 Flavokinase, 1 hit
SUPFAMiSSF82114 SSF82114, 1 hit
TIGRFAMsiTIGR00083 ribF, 1 hit

Sequencei

Sequence statusi: Complete.

G0TF93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRRLAIVQR WRGQDEIPTD WGRCVLTIGV FDGVHRGHAE LIAHAVKAGR
60 70 80 90 100
ARGVPAVLMT FDPHPMEVVY PGSHPAQLTT LTRRAELVQD LGIEVFLVMP
110 120 130 140 150
FTTDFMKLTP DRFIHELLVE HLHVVEVVVG ENFTFGKKAA GNVDTLRRAG
160 170 180 190 200
ERFGFAVESM SLVSEHHSNE TVTFSSTYIR SCVDAGDMVA AMEALGRPHR
210 220 230 240 250
VEGVVVRGEG RGAELGFPTA NVAPPMYSAI PADGVYAAWF TVLGHGPVTG
260 270 280 290 300
TVVPGERYQA AVSVGTNPTF SGRTRTVEAF VLDTTADLYG QHVALDFVGR
310 320 330
IRGQKKFESV RQLVAAMGAD TERARDLLSR G
Length:331
Mass (Da):36,145
Last modified:October 19, 2011 - v1
Checksum:i64C0D82716B255BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE572590 Genomic DNA Translation: CCC45145.1

Genome annotation databases

EnsemblBacteriaiCCC45145; CCC45145; MCAN_28141
KEGGimce:MCAN_28141

Similar proteinsi

Entry informationi

Entry nameiG0TF93_MYCCP
AccessioniPrimary (citable) accession number: G0TF93
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: March 28, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health