Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

L-lactate dehydrogenase

Gene

CAEBREN_12160

Organism
Caenorhabditis brenneri (Nematode worm)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (CAEBREN_12160)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei193Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
ORF Names:CAEBREN_12160Imported, CAEBREN_21352Imported
OrganismiCaenorhabditis brenneri (Nematode worm)Imported
Taxonomic identifieri135651 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008068 Componenti: Unassembled WGS sequence

Subcellular locationi

Interactioni

Protein-protein interaction databases

STRINGi135651.CBN21352.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 160Ldh_1_NInterPro annotationAdd BLAST139
Domaini163 – 326Ldh_1_CInterPro annotationAdd BLAST164

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1495. Eukaryota.
COG0039. LUCA.
OMAiRQPGQTR.
OrthoDBiEOG091G0HME.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiView protein in PROSITE
PS00064. L_LDH. 1 hit.

Sequencei

Sequence statusi: Complete.

G0PD52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTIKEVFA EIAPAVDNSH GKVTVVGVGQ VGMACAYSIL QQNIANELCL
60 70 80 90 100
VDVVADKLKG EMMDLQHGLA FTRHCTVKAD TDYSITAGSK LCVVTAGARQ
110 120 130 140 150
REGETRLSLV QRNVEIFKGI IPQLVKYSPD TCILVVSNPV DVLTYVTWKL
160 170 180 190 200
SGLPRERVFG SGTNLDSARF RFLLSEKLNI APSSCHGWII GEHGDSSVAV
210 220 230 240 250
WSGVNVAGVT LHDVKPDIGE KTDNEHWEAE IHKKVVDSAY EIIKLKGYTS
260 270 280 290 300
WAIGLSVAKI AQGIFSNSRN VFALSTNVKG FHGINDDVYL SLPVVLGSAG
310 320 330
LTHVVKQHLT EVEVEKLHKS AKALLEVQDG IVM
Length:333
Mass (Da):36,076
Last modified:October 19, 2011 - v1
Checksum:i0188FC2DF5D60535
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL379942 Genomic DNA. Translation: EGT37077.1.
GL380264 Genomic DNA. Translation: EGT51506.1.

Genome annotation databases

EnsemblMetazoaiCBN12160; CBN12160; WBGene00150885.
CBN21352; CBN21352; WBGene00160077.

Similar proteinsi

Entry informationi

Entry nameiG0PD52_CAEBE
AccessioniPrimary (citable) accession number: G0PD52
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: October 25, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported