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G0LLH9

- G0LLH9_HALWC

UniProt

G0LLH9 - G0LLH9_HALWC

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Protein

DNA ligase

Gene

ligB2

Organism
Haloquadratum walsbyi (strain DSM 16854 / JCM 12705 / C23)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei312 – 3121ATPUniRule annotation
Active sitei314 – 3141N6-AMP-lysine intermediateUniRule annotation
Binding sitei319 – 3191ATPUniRule annotation
Binding sitei334 – 3341ATPUniRule annotation
Binding sitei363 – 3631ATPUniRule annotation
Binding sitei403 – 4031ATPUniRule annotation
Binding sitei476 – 4761ATPUniRule annotation
Binding sitei482 – 4821ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciHWAL768065:GLDV-2161-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligB2Imported
Synonyms:ligUniRule annotation
Ordered Locus Names:Hqrw_2987Imported
OrganismiHaloquadratum walsbyi (strain DSM 16854 / JCM 12705 / C23)Imported
Taxonomic identifieri768065 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloquadratum
ProteomesiUP000007954: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G0LLH9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQFDDFANHV ITIEAESADL EITSLVSKLL TTAGNMDDKT LSIVVRFIKG
60 70 80 90 100
TVFPAWSSQT LDIGPALLHT TIAQAAGPNV DSADVENRLA EYGEIGAVAA
110 120 130 140 150
SYDLNGQQGL SAFTPSTPDS LTVGHVDKTL RAVASASGDG SESRRRNLLF
160 170 180 190 200
GLFSQASSSE ARVLARLILG EMRIGVGTGT VRDAIISGFI EPAADADKKT
210 220 230 240 250
LESREDAESV PPASQPEMTN KISGDTSPNT SESVQTKESD PDTSSNVDPS
260 270 280 290 300
AVVERALQVS NDYGMVATIA RNQGQAGLID ISLEVGRPIQ AMLAQAADGV
310 320 330 340 350
DAVDTWDAVA IETKFDGARV QIHTDGESVS LYSRNMEDVT DPLPEIVEFI
360 370 380 390 400
SQKVTVPAIL DAEVVAVSDD DDPLAFQEVL RRFRRKYDID AMRESVNLNV
410 420 430 440 450
YVFDCLHIDD ADLLDIPLRE RRERLRELFN TTDALSPFQL TTDPNVIAQA
460 470 480 490 500
RSKALSNGHE GVMLKDPDST YNPGSRGQHW LKHKPDVETL DLVVTGAEWG
510 520 530 540 550
EGRRANVFGT FVVSARTTAD EQQFNSLGKV ATGLTDDQLT TLTEQLRPHV
560 570 580 590 600
RSEDGQTVMI EPAIVVEVGY EEIQRSPTYD SGFALRFPRV VGIRHDKAIS
610
DVDSLSRIKH LTTGESPD
Length:618
Mass (Da):67,028
Last modified:October 19, 2011 - v1
Checksum:i024B04FA96F60CED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR746099 Genomic DNA. Translation: CCC40785.1.
RefSeqiWP_014556319.1. NC_017459.1.
YP_005840430.1. NC_017459.1.

Genome annotation databases

EnsemblBacteriaiCCC40785; CCC40785; Hqrw_2987.
GeneIDi12447762.
KEGGihwc:Hqrw_2987.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR746099 Genomic DNA. Translation: CCC40785.1 .
RefSeqi WP_014556319.1. NC_017459.1.
YP_005840430.1. NC_017459.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCC40785 ; CCC40785 ; Hqrw_2987 .
GeneIDi 12447762.
KEGGi hwc:Hqrw_2987.

Phylogenomic databases

KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci HWAL768065:GLDV-2161-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16854 / JCM 12705 / C23Imported.

Entry informationi

Entry nameiG0LLH9_HALWC
AccessioniPrimary (citable) accession number: G0LLH9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: October 29, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3