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G0LKX0

- G0LKX0_HALWC

UniProt

G0LKX0 - G0LKX0_HALWC

Protein

DNA ligase

Gene

ligB1

Organism
Haloquadratum walsbyi (strain DSM 16854 / JCM 12705 / C23)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei272 – 2721ATPUniRule annotation
    Active sitei274 – 2741N6-AMP-lysine intermediateUniRule annotation
    Binding sitei279 – 2791ATPUniRule annotation
    Binding sitei294 – 2941ATPUniRule annotation
    Binding sitei324 – 3241ATPUniRule annotation
    Binding sitei367 – 3671ATPUniRule annotation
    Binding sitei472 – 4721ATPUniRule annotation
    Binding sitei478 – 4781ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHWAL768065:GLDV-1693-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligB1Imported
    Synonyms:ligUniRule annotation
    Ordered Locus Names:Hqrw_2571Imported
    OrganismiHaloquadratum walsbyi (strain DSM 16854 / JCM 12705 / C23)Imported
    Taxonomic identifieri768065 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloquadratum
    ProteomesiUP000007954: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliG0LKX0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10747.
    OMAiKSASTHN.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G0LKX0-1 [UniParc]FASTAAdd to Basket

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    MKYSELAEVY TDVAATSATT QKGTLLADCF LDVYNNTEKS LLPVTVRLVQ    50
    GRVFARWEAA EIGVSTAGAA DAISKATGVE SEQIETWWRE EGDLGDAAAY 100
    AVDDRVQQTL TATPLTVTRV YETLREVASY AGSGSQQKQR DEIAGLISDA 150
    SPLAARYIVR TVTGSMRLGV GEGIVRNALA SAFLDMSDDA ADAVQRAIDL 200
    TNDVAVVAQR VAEQGQPGLD DVDLELFRPI KPMLAKQAES IQTAVDELAA 250
    DPKHIERNHN IELSHSGAVL IEFKYDGIRA KIHRDGDEIR VYTRRLSDVT 300
    EQFPDVVSAA RDHIDAEHYI IEAELVGYDP QSNDDTPVTF QTLAQRIQRT 350
    DNVATIAKSI PVTTYVFDLL ALNGESLLTD TLEMRLERLN TILSTKATSD 400
    SKSASTHNAH SSTSVTTVSN DQYQSSSSLR RAQCTWATTQ TTATEFYEDA 450
    LAAGHEGVMI KNPTRPYQPG SRVGYQRKIK PTMEPLDLVV TRAKWSEGRK 500
    SDFLGRPYLA CRTADGNLAE VGRMHTGFTD DQLETFTNRV EPLIEHVEGR 550
    EATLTPAVVL AVEYEEIQIS STYDSGYALR FPRLKQIRHD CDPSQADSLE 600
    RVERLYEQQS LDESQTSV 618
    Length:618
    Mass (Da):68,156
    Last modified:October 19, 2011 - v1
    Checksum:i9A541CF94B3C8A1D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FR746099 Genomic DNA. Translation: CCC40410.1.
    RefSeqiYP_005840086.1. NC_017459.1.

    Genome annotation databases

    EnsemblBacteriaiCCC40410; CCC40410; Hqrw_2571.
    GeneIDi12447293.
    KEGGihwc:Hqrw_2571.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FR746099 Genomic DNA. Translation: CCC40410.1 .
    RefSeqi YP_005840086.1. NC_017459.1.

    3D structure databases

    ProteinModelPortali G0LKX0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCC40410 ; CCC40410 ; Hqrw_2571 .
    GeneIDi 12447293.
    KEGGi hwc:Hqrw_2571.

    Phylogenomic databases

    KOi K10747.
    OMAi KSASTHN.

    Enzyme and pathway databases

    BioCyci HWAL768065:GLDV-1693-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 16854 / JCM 12705 / C23Imported.

    Entry informationi

    Entry nameiG0LKX0_HALWC
    AccessioniPrimary (citable) accession number: G0LKX0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 19, 2011
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3