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G0LKX0

- G0LKX0_HALWC

UniProt

G0LKX0 - G0LKX0_HALWC

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Protein

DNA ligase

Gene
ligB1, lig, Hqrw_2571
Organism
Haloquadratum walsbyi (strain DSM 16854 / JCM 12705 / C23)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei272 – 2721ATP By similarityUniRule annotation
Active sitei274 – 2741N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei279 – 2791ATP By similarityUniRule annotation
Binding sitei294 – 2941ATP By similarityUniRule annotation
Binding sitei324 – 3241ATP By similarityUniRule annotation
Binding sitei367 – 3671ATP By similarityUniRule annotation
Binding sitei472 – 4721ATP By similarityUniRule annotation
Binding sitei478 – 4781ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciHWAL768065:GLDV-1693-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligB1Imported
Synonyms:ligUniRule annotation
Ordered Locus Names:Hqrw_2571Imported
OrganismiHaloquadratum walsbyi (strain DSM 16854 / JCM 12705 / C23)Imported
Taxonomic identifieri768065 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloquadratum
ProteomesiUP000007954: Chromosome

Structurei

3D structure databases

ProteinModelPortaliG0LKX0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK10747.
OMAiKSASTHN.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G0LKX0-1 [UniParc]FASTAAdd to Basket

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MKYSELAEVY TDVAATSATT QKGTLLADCF LDVYNNTEKS LLPVTVRLVQ    50
GRVFARWEAA EIGVSTAGAA DAISKATGVE SEQIETWWRE EGDLGDAAAY 100
AVDDRVQQTL TATPLTVTRV YETLREVASY AGSGSQQKQR DEIAGLISDA 150
SPLAARYIVR TVTGSMRLGV GEGIVRNALA SAFLDMSDDA ADAVQRAIDL 200
TNDVAVVAQR VAEQGQPGLD DVDLELFRPI KPMLAKQAES IQTAVDELAA 250
DPKHIERNHN IELSHSGAVL IEFKYDGIRA KIHRDGDEIR VYTRRLSDVT 300
EQFPDVVSAA RDHIDAEHYI IEAELVGYDP QSNDDTPVTF QTLAQRIQRT 350
DNVATIAKSI PVTTYVFDLL ALNGESLLTD TLEMRLERLN TILSTKATSD 400
SKSASTHNAH SSTSVTTVSN DQYQSSSSLR RAQCTWATTQ TTATEFYEDA 450
LAAGHEGVMI KNPTRPYQPG SRVGYQRKIK PTMEPLDLVV TRAKWSEGRK 500
SDFLGRPYLA CRTADGNLAE VGRMHTGFTD DQLETFTNRV EPLIEHVEGR 550
EATLTPAVVL AVEYEEIQIS STYDSGYALR FPRLKQIRHD CDPSQADSLE 600
RVERLYEQQS LDESQTSV 618
Length:618
Mass (Da):68,156
Last modified:October 19, 2011 - v1
Checksum:i9A541CF94B3C8A1D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR746099 Genomic DNA. Translation: CCC40410.1.
RefSeqiYP_005840086.1. NC_017459.1.

Genome annotation databases

EnsemblBacteriaiCCC40410; CCC40410; Hqrw_2571.
GeneIDi12447293.
KEGGihwc:Hqrw_2571.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR746099 Genomic DNA. Translation: CCC40410.1 .
RefSeqi YP_005840086.1. NC_017459.1.

3D structure databases

ProteinModelPortali G0LKX0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCC40410 ; CCC40410 ; Hqrw_2571 .
GeneIDi 12447293.
KEGGi hwc:Hqrw_2571.

Phylogenomic databases

KOi K10747.
OMAi KSASTHN.

Enzyme and pathway databases

BioCyci HWAL768065:GLDV-1693-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16854 / JCM 12705 / C23.

Entry informationi

Entry nameiG0LKX0_HALWC
AccessioniPrimary (citable) accession number: G0LKX0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: June 11, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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