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Protein

Thymidine kinase

Gene

tdk

Organism
Haloquadratum walsbyi (strain DSM 16854 / JCM 12705 / C23)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei122Proton acceptorUniRule annotation1
Metal bindingi178ZincUniRule annotation1
Metal bindingi181ZincUniRule annotation1
Metal bindingi216ZincUniRule annotation1
Metal bindingi219ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22ATPUniRule annotation8
Nucleotide bindingi121 – 124ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:Hqrw_1931Imported
OrganismiHaloquadratum walsbyi (strain DSM 16854 / JCM 12705 / C23)Imported
Taxonomic identifieri768065 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHaloferacalesHaloferacaceaeHaloquadratum
Proteomesi
  • UP000007954 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.
OMAiVITGPMY.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 2 hits.
PfamiPF00265. TK. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G0LIC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAITNSGWI EVVTGSMFSG KTEELLRRLR RAEIAGQSIA VFKPAVDDRY
60 70 80 90 100
GETTVGSHVG RQWEAAVVPN EGEDIWNIKD ELSKKKQNHR TTTQCRSGDG
110 120 130 140 150
TNNPGGVIPS NDDSVDVVAI DEANFFSTEL VSVCESLAND GYRVVVSGTD
160 170 180 190 200
QTYRGEPFEP LPQLMAVAEY VDKLQAICTQ CGEPATRNQR LVDDSPAHID
210 220
DPTIVVGADE TYEARCRNCH ILRHE
Length:225
Mass (Da):24,811
Last modified:October 19, 2011 - v1
Checksum:i65AD911EB1C512DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR746099 Genomic DNA. Translation: CCC39846.1.
RefSeqiWP_014555602.1. NC_017459.1.

Genome annotation databases

EnsemblBacteriaiCCC39846; CCC39846; Hqrw_1931.
GeneIDi12446635.
KEGGihwc:Hqrw_1931.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR746099 Genomic DNA. Translation: CCC39846.1.
RefSeqiWP_014555602.1. NC_017459.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCC39846; CCC39846; Hqrw_1931.
GeneIDi12446635.
KEGGihwc:Hqrw_1931.

Phylogenomic databases

KOiK00857.
OMAiVITGPMY.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 2 hits.
PfamiPF00265. TK. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG0LIC6_HALWC
AccessioniPrimary (citable) accession number: G0LIC6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: November 2, 2016
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.