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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwfA

Organism
Zobellia galactanivorans (strain DSM 12802 / CIP 106680 / NCIMB 13871 / Dsij)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathway: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwfA)
  2. no protein annotated in this organism
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gndA)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei47 – 471NADPUniRule annotation
Binding sitei155 – 1551NADPUniRule annotation
Binding sitei185 – 1851SubstrateUniRule annotation
Binding sitei189 – 1891SubstrateUniRule annotation
Binding sitei223 – 2231SubstrateUniRule annotation
Binding sitei242 – 2421SubstrateUniRule annotation
Active sitei247 – 2471Proton acceptorUniRule annotation
Binding sitei348 – 3481SubstrateUniRule annotation
Binding sitei353 – 3531SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolismUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

BioCyciZGAL63186:GJN9-67-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfAImported
Synonyms:zwfUniRule annotation
Ordered Locus Names:zobellia_66Imported
OrganismiZobellia galactanivorans (strain DSM 12802 / CIP 106680 / NCIMB 13871 / Dsij)Imported
Taxonomic identifieri63186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeZobellia
ProteomesiUP000008898 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

KOiK00036.
OMAiTIFEPIW.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G0KZV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKTENQILV IFGASGDLTA RKLVPALFNL YLAGQLPENF VVLGASRSDM
60 70 80 90 100
TDNAFRNKVV LESTYLKTKI KEHSDDYIKA FANKFFYEDL GGSYDTDYGR
110 120 130 140 150
LRKRVEDLKN KYQTSGNIIY YLSTPPTLYE TIAQRLADAG MSTQNNGWKR
160 170 180 190 200
MIVEKPFGYS LETAKQLNQG LQQFFEEHQI YRIDHYLGKE TVQNLLVTRF
210 220 230 240 250
ANSIFEPLWN RNYIHHVEIT NAESVGVEKR GGYYDKSGAL RDMFQNHLLQ
260 270 280 290 300
IVSLIVMEPP ISDAPEDIRN EKVKALKSLR VMKDEQELFD NTIRAQYTSS
310 320 330 340 350
VIDGEPVKGY REEEGVDKNS TTETYAAIKF FVDNWRWKDT PFYVRTAKRM
360 370 380 390 400
PTKVTEVVIH FKTPHHQVFQ ESGLDNKDNK LVIRIQPDEG ILIKFGVKVP
410 420 430 440 450
GQGFKVERAN LDFYYSSLAE THVMEAYERL LLDAMQGDAT LYARADEVEA
460 470 480 490 500
AWEFVDPILK YWESGKDVRM YGYAAGVWGP ENSNELIDGI GEWRNPGASL
510
TDDPGFCVIC
Length:510
Mass (Da):58,475
Last modified:October 19, 2011 - v1
Checksum:i0D0BCE76D2BFD396
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP476056 Genomic DNA. Translation: CAZ94139.1.
RefSeqiWP_013991452.1. NC_015844.1.
YP_004734531.1. NC_015844.1.

Genome annotation databases

GeneIDi10978338.
KEGGizga:zobellia_66.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP476056 Genomic DNA. Translation: CAZ94139.1.
RefSeqiWP_013991452.1. NC_015844.1.
YP_004734531.1. NC_015844.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi10978338.
KEGGizga:zobellia_66.

Phylogenomic databases

KOiK00036.
OMAiTIFEPIW.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.
BioCyciZGAL63186:GJN9-67-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Zobellia galactanivorans Dsij."
    Genoscope - CEA
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 12802 / CIP 106680 / NCIMB 13871 / DsijImported.

Entry informationi

Entry nameiG0KZV6_ZOBGA
AccessioniPrimary (citable) accession number: G0KZV6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: April 29, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.