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G0JQJ6

- G0JQJ6_9GAMM

UniProt

G0JQJ6 - G0JQJ6_9GAMM

Protein

NADH-quinone oxidoreductase subunit H

Gene

nuoH

Organism
Acidithiobacillus ferrivorans SS3
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 14 (01 Oct 2014)
      Sequence version 1 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.UniRule annotation

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.UniRule annotation

    GO - Molecular functioni

    1. NADH dehydrogenase (quinone) activity Source: UniProtKB-EC
    2. quinone binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Ligandi

    NADUniRule annotation, UbiquinoneUniRule annotation

    Enzyme and pathway databases

    BioCyciAFER743299:GH39-2586-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit HUniRule annotation (EC:1.6.99.5UniRule annotation)
    Alternative name(s):
    NADH dehydrogenase I subunit HUniRule annotation
    NDH-1 subunit HUniRule annotation
    Gene namesi
    Name:nuoHUniRule annotation
    ORF Names:Acife_2547Imported
    OrganismiAcidithiobacillus ferrivorans SS3Imported
    Taxonomic identifieri743299 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAcidithiobacillalesAcidithiobacillaceaeAcidithiobacillus
    ProteomesiUP000009220: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
    Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membraneUniRule annotation, Membrane

    PTM / Processingi

    Keywords - PTMi

    QuinoneUniRule annotation

    Interactioni

    Subunit structurei

    NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021Helical;UniRule annotationAdd
    BLAST
    Transmembranei82 – 10221Helical;UniRule annotationAdd
    BLAST
    Transmembranei117 – 13721Helical;UniRule annotationAdd
    BLAST
    Transmembranei151 – 17121Helical;UniRule annotationAdd
    BLAST
    Transmembranei189 – 20921Helical;UniRule annotationAdd
    BLAST
    Transmembranei247 – 26923Helical;UniRule annotationAdd
    BLAST
    Transmembranei277 – 29721Helical;UniRule annotationAdd
    BLAST
    Transmembranei312 – 33221Helical;UniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 1 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixUniRule annotation

    Phylogenomic databases

    KOiK00337.

    Family and domain databases

    HAMAPiMF_01350. NDH1_NuoH.
    InterProiIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
    IPR018086. NADH_UbQ_OxRdtase_su1_CS.
    [Graphical view]
    PANTHERiPTHR11432. PTHR11432. 1 hit.
    PfamiPF00146. NADHdh. 1 hit.
    [Graphical view]
    PROSITEiPS00667. COMPLEX1_ND1_1. 1 hit.
    PS00668. COMPLEX1_ND1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G0JQJ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHDFQNTAWW AILWSLIKIV IVVVPLLLGV AYLTLAERKV IGYMQVRLGP    50
    NRVGFKGSLQ PIADAIKLMF KEVIIPTNAN RFLFLAAPVL AFVPALLVWA 100
    AIPFGPGVAI SNMNAGLLYV LAIAGLGVYG IIVAGWASNS KYAFLGAMRA 150
    AAQLVAYEIA MGFALVGVLM LAQTLNLSKI VEAQAGGGFW SWYWLPLFPF 200
    FLVYFISGIA ETNRAPFDVA EGESEIVAGF HVEYSGMAFA LFFLAEYANM 250
    IFVSLLTTVL FLGGWYAPIN TPLLTWIPGI VWLLLKTAFL LYVFLWIRAT 300
    FPRYRYDQIM RLGWKVFIPV TIAWIVIVGV ALETPLRAIL R 341
    Length:341
    Mass (Da):37,811
    Last modified:October 19, 2011 - v1
    Checksum:iF352A5A8FEB8DC9B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002985 Genomic DNA. Translation: AEM48635.1.
    RefSeqiWP_014029884.1. NC_015942.1.
    YP_004784961.1. NC_015942.1.

    Genome annotation databases

    EnsemblBacteriaiAEM48635; AEM48635; Acife_2547.
    GeneIDi11043310.
    KEGGiafi:Acife_2547.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002985 Genomic DNA. Translation: AEM48635.1 .
    RefSeqi WP_014029884.1. NC_015942.1.
    YP_004784961.1. NC_015942.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEM48635 ; AEM48635 ; Acife_2547 .
    GeneIDi 11043310.
    KEGGi afi:Acife_2547.

    Phylogenomic databases

    KOi K00337.

    Enzyme and pathway databases

    BioCyci AFER743299:GH39-2586-MONOMER.

    Family and domain databases

    HAMAPi MF_01350. NDH1_NuoH.
    InterProi IPR001694. NADH_UbQ_OxRdtase_su1/FPO.
    IPR018086. NADH_UbQ_OxRdtase_su1_CS.
    [Graphical view ]
    PANTHERi PTHR11432. PTHR11432. 1 hit.
    Pfami PF00146. NADHdh. 1 hit.
    [Graphical view ]
    PROSITEi PS00667. COMPLEX1_ND1_1. 1 hit.
    PS00668. COMPLEX1_ND1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Draft genome of the psychrotolerant acidophile Acidithiobacillus ferrivorans SS3."
      Liljeqvist M., Valdes J., Holmes D.S., Dopson M.
      J. Bacteriol. 193:4304-4305(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SS3Imported.

    Entry informationi

    Entry nameiG0JQJ6_9GAMM
    AccessioniPrimary (citable) accession number: G0JQJ6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 19, 2011
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 14 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3