Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NADH-quinone oxidoreductase subunit H

Gene

nuoH

Organism
Acidithiobacillus ferrivorans SS3
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (quinone) activity Source: UniProtKB-EC
  2. quinone binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

NADUniRule annotation, UbiquinoneUniRule annotation

Enzyme and pathway databases

BioCyciAFER743299:GH39-2586-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit HUniRule annotation (EC:1.6.99.5UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit HUniRule annotation
NDH-1 subunit HUniRule annotation
Gene namesi
Name:nuoHUniRule annotation
ORF Names:Acife_2547Imported
OrganismiAcidithiobacillus ferrivorans SS3Imported
Taxonomic identifieri743299 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAcidithiobacillalesAcidithiobacillaceaeAcidithiobacillus
ProteomesiUP000009220: Chromosome

Subcellular locationi

Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021HelicalUniRule annotationAdd
BLAST
Transmembranei82 – 10221HelicalUniRule annotationAdd
BLAST
Transmembranei117 – 13721HelicalUniRule annotationAdd
BLAST
Transmembranei151 – 17121HelicalUniRule annotationAdd
BLAST
Transmembranei189 – 20921HelicalUniRule annotationAdd
BLAST
Transmembranei247 – 26923HelicalUniRule annotationAdd
BLAST
Transmembranei277 – 29721HelicalUniRule annotationAdd
BLAST
Transmembranei312 – 33221HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

PTM / Processingi

Keywords - PTMi

QuinoneUniRule annotation

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

KOiK00337.

Family and domain databases

HAMAPiMF_01350. NDH1_NuoH.
InterProiIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view]
PANTHERiPTHR11432. PTHR11432. 1 hit.
PfamiPF00146. NADHdh. 1 hit.
[Graphical view]
PROSITEiPS00667. COMPLEX1_ND1_1. 1 hit.
PS00668. COMPLEX1_ND1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G0JQJ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHDFQNTAWW AILWSLIKIV IVVVPLLLGV AYLTLAERKV IGYMQVRLGP
60 70 80 90 100
NRVGFKGSLQ PIADAIKLMF KEVIIPTNAN RFLFLAAPVL AFVPALLVWA
110 120 130 140 150
AIPFGPGVAI SNMNAGLLYV LAIAGLGVYG IIVAGWASNS KYAFLGAMRA
160 170 180 190 200
AAQLVAYEIA MGFALVGVLM LAQTLNLSKI VEAQAGGGFW SWYWLPLFPF
210 220 230 240 250
FLVYFISGIA ETNRAPFDVA EGESEIVAGF HVEYSGMAFA LFFLAEYANM
260 270 280 290 300
IFVSLLTTVL FLGGWYAPIN TPLLTWIPGI VWLLLKTAFL LYVFLWIRAT
310 320 330 340
FPRYRYDQIM RLGWKVFIPV TIAWIVIVGV ALETPLRAIL R
Length:341
Mass (Da):37,811
Last modified:October 19, 2011 - v1
Checksum:iF352A5A8FEB8DC9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002985 Genomic DNA. Translation: AEM48635.1.
RefSeqiWP_014029884.1. NC_015942.1.
YP_004784961.1. NC_015942.1.

Genome annotation databases

EnsemblBacteriaiAEM48635; AEM48635; Acife_2547.
GeneIDi11043310.
KEGGiafi:Acife_2547.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002985 Genomic DNA. Translation: AEM48635.1.
RefSeqiWP_014029884.1. NC_015942.1.
YP_004784961.1. NC_015942.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEM48635; AEM48635; Acife_2547.
GeneIDi11043310.
KEGGiafi:Acife_2547.

Phylogenomic databases

KOiK00337.

Enzyme and pathway databases

BioCyciAFER743299:GH39-2586-MONOMER.

Family and domain databases

HAMAPiMF_01350. NDH1_NuoH.
InterProiIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view]
PANTHERiPTHR11432. PTHR11432. 1 hit.
PfamiPF00146. NADHdh. 1 hit.
[Graphical view]
PROSITEiPS00667. COMPLEX1_ND1_1. 1 hit.
PS00668. COMPLEX1_ND1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Draft genome of the psychrotolerant acidophile Acidithiobacillus ferrivorans SS3."
    Liljeqvist M., Valdes J., Holmes D.S., Dopson M.
    J. Bacteriol. 193:4304-4305(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SS3Imported.

Entry informationi

Entry nameiG0JQJ6_9GAMM
AccessioniPrimary (citable) accession number: G0JQJ6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: February 4, 2015
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.