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Protein

NADH-quinone oxidoreductase subunit H

Gene

nuoH

Organism
Acidithiobacillus ferrivorans SS3
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.UniRule annotation

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation, UbiquinoneUniRule annotation

Enzyme and pathway databases

BioCyciAFER743299:G1GXS-2489-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit HUniRule annotation (EC:1.6.5.11UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit HUniRule annotation
NDH-1 subunit HUniRule annotation
Gene namesi
Name:nuoHUniRule annotation
ORF Names:Acife_2547Imported
OrganismiAcidithiobacillus ferrivorans SS3Imported
Taxonomic identifieri743299 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAcidithiobacilliaAcidithiobacillalesAcidithiobacillaceaeAcidithiobacillus
Proteomesi
  • UP000009220 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 35HelicalUniRule annotationAdd BLAST24
Transmembranei82 – 104HelicalUniRule annotationAdd BLAST23
Transmembranei116 – 138HelicalUniRule annotationAdd BLAST23
Transmembranei150 – 172HelicalUniRule annotationAdd BLAST23
Transmembranei192 – 210HelicalUniRule annotationAdd BLAST19
Transmembranei247 – 267HelicalUniRule annotationAdd BLAST21
Transmembranei273 – 297HelicalUniRule annotationAdd BLAST25
Transmembranei309 – 332HelicalUniRule annotationAdd BLAST24

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

PTM / Processingi

Keywords - PTMi

QuinoneUniRule annotation

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMZ Bacteria
COG1005 LUCA
KOiK00337
OrthoDBiPOG091H0A0A

Family and domain databases

HAMAPiMF_01350 NDH1_NuoH, 1 hit
InterProiView protein in InterPro
IPR001694 NADH_UbQ_OxRdtase_su1/FPO
IPR018086 NADH_UbQ_OxRdtase_su1_CS
PANTHERiPTHR11432 PTHR11432, 1 hit
PfamiView protein in Pfam
PF00146 NADHdh, 1 hit
PROSITEiView protein in PROSITE
PS00667 COMPLEX1_ND1_1, 1 hit
PS00668 COMPLEX1_ND1_2, 1 hit

Sequencei

Sequence statusi: Complete.

G0JQJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHDFQNTAWW AILWSLIKIV IVVVPLLLGV AYLTLAERKV IGYMQVRLGP
60 70 80 90 100
NRVGFKGSLQ PIADAIKLMF KEVIIPTNAN RFLFLAAPVL AFVPALLVWA
110 120 130 140 150
AIPFGPGVAI SNMNAGLLYV LAIAGLGVYG IIVAGWASNS KYAFLGAMRA
160 170 180 190 200
AAQLVAYEIA MGFALVGVLM LAQTLNLSKI VEAQAGGGFW SWYWLPLFPF
210 220 230 240 250
FLVYFISGIA ETNRAPFDVA EGESEIVAGF HVEYSGMAFA LFFLAEYANM
260 270 280 290 300
IFVSLLTTVL FLGGWYAPIN TPLLTWIPGI VWLLLKTAFL LYVFLWIRAT
310 320 330 340
FPRYRYDQIM RLGWKVFIPV TIAWIVIVGV ALETPLRAIL R
Length:341
Mass (Da):37,811
Last modified:October 19, 2011 - v1
Checksum:iF352A5A8FEB8DC9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002985 Genomic DNA Translation: AEM48635.1
RefSeqiWP_014029884.1, NC_015942.1

Genome annotation databases

EnsemblBacteriaiAEM48635; AEM48635; Acife_2547
KEGGiafi:Acife_2547

Similar proteinsi

Entry informationi

Entry nameiG0JQJ6_9PROT
AccessioniPrimary (citable) accession number: G0JQJ6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: April 25, 2018
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health