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Protein

Isocitrate dehydrogenase [NADP]

Gene

A1122_17675

Organism
Yersinia pestis A1122
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Note: Binds 1 magnesium or manganese ion per subunit.
  • Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciYPES1035377:GLMV-3534-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:A1122_17675Imported
OrganismiYersinia pestis A1122Imported
Taxonomic identifieri1035377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000002491: Chromosome

Structurei

3D structure databases

ProteinModelPortaliG0JJY6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.
OMAiFRDWGYE.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G0JJY6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESKVVVPAE GKKITVDAQG KLVVPHNPII PFIEGDGIGV DVTPAMINVV
60 70 80 90 100
DAAVKKAYNG ERKISWMEIY TGEKSTHVYG KDVWLPEETL DLIRDYRVAI
110 120 130 140 150
KGPLTTPVGG GIRSLNVALR QQLDLYVCLR PVRYYEGTPS PVKHPELTNM
160 170 180 190 200
VIFRENAEDI YAGIEWKAGS PEAEKVIKFL REEMGVKKIR FPEQCGIGVK
210 220 230 240 250
PCSEEGTKRL VRAAIEYAIT NDRESVTLVH KGNIMKFTEG AFKDWGYQLA
260 270 280 290 300
REEFGGELID GGPWVKIKNP NNGKEIIVKD VIADAFLQQI LLRPAEYDVI
310 320 330 340 350
ACMNLNGDYI SDALAAQVGG IGIAPGANIG DDCALFEATH GTAPKYAGQD
360 370 380 390 400
KVNPGSIILS AEMMLRHMGW FEAADLIIKG TEGAIQAKTV TYDFERLMEG
410
AKLLKCSEFG DAIIKHM
Length:417
Mass (Da):45,868
Last modified:October 19, 2011 - v1
Checksum:iF908FB962F0F4932
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002956 Genomic DNA. Translation: AEL74152.1.
RefSeqiYP_005523172.1. NC_017168.1.

Genome annotation databases

EnsemblBacteriaiAEL74152; AEL74152; A1122_17675.
GeneIDi12112174.
KEGGiypt:A1122_17675.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002956 Genomic DNA. Translation: AEL74152.1.
RefSeqiYP_005523172.1. NC_017168.1.

3D structure databases

ProteinModelPortaliG0JJY6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEL74152; AEL74152; A1122_17675.
GeneIDi12112174.
KEGGiypt:A1122_17675.

Phylogenomic databases

KOiK00031.
OMAiFRDWGYE.

Enzyme and pathway databases

BioCyciYPES1035377:GLMV-3534-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Finished sequence of Yersinia pestis A1122."
    Doggett N., Munk A.C., Bruce D.C., Detter J.C., Johnson S.L., Han C.
    Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A1122Imported.

Entry informationi

Entry nameiG0JJY6_YERPE
AccessioniPrimary (citable) accession number: G0JJY6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: February 4, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.