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G0IVQ1

- G0IVQ1_CYCMS

UniProt

G0IVQ1 - G0IVQ1_CYCMS

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Protein

Diaminopimelate decarboxylase

Gene
lysA, Cycma_1046
Organism
Cyclobacterium marinum (strain ATCC 25205 / DSM 745) (Flectobacillus marinus)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine By similarity.UniRule annotation

Catalytic activityi

Meso-2,6-diaminoheptanedioate = L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei227 – 2271Pyridoxal phosphate; via amide nitrogen By similarityUniRule annotation
Binding sitei307 – 3071Substrate By similarityUniRule annotation
Binding sitei311 – 3111Substrate By similarityUniRule annotation
Binding sitei338 – 3381Substrate By similarityUniRule annotation
Binding sitei365 – 3651Pyridoxal phosphate By similarityUniRule annotation
Binding sitei365 – 3651Substrate By similarityUniRule annotation

GO - Molecular functioni

  1. diaminopimelate decarboxylase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotationSAAS annotations, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciCMAR880070:GHDK-1054-MONOMER.
UniPathwayiUPA00034; UER00027.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate decarboxylaseUniRule annotation (EC:4.1.1.20UniRule annotation)
Short name:
DAP decarboxylaseUniRule annotation
Short name:
DAPDCUniRule annotation
Gene namesi
Name:lysAUniRule annotation
Ordered Locus Names:Cycma_1046Imported
OrganismiCyclobacterium marinum (strain ATCC 25205 / DSM 745) (Flectobacillus marinus)Imported
Taxonomic identifieri880070 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCyclobacteriaceaeCyclobacterium
ProteomesiUP000001635: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei57 – 571N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliG0IVQ1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01586.
OMAiSNYNRIG.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_02120. LysA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002986. DAP_deCOOHase_LysA.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01181. DAPDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01048. lysA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G0IVQ1-1 [UniParc]FASTAAdd to Basket

« Hide

MEIKNQQYCI GGIPLLNIAE KYGSPVYVYD GEKILHQVES LKKAFADVKM    50
KIKYATKALS NINILKLMKK AGTGVDAVSI EEVKLCLHVG FSPEEIMYTP 100
NCVDFEEIKE AVAYGVMVNI DSIPMLEHFG TEYGNDVPIC IRLNPHILAG 150
GNAKISVGHI DSKFGISILQ LKHVIKVVQA YDLNVVGLHV HTGSDILDAE 200
VFLQGAEILF DAAREFKDLA FLDFGGGFKV AYKNGDITTD IQDVGKKVSA 250
AFKKFCKEYG RELEIWFEPG KFLVSECGYL LTKANVVKPT PATTFVGVNS 300
GLNHLLRPMM YDAYHSVVNI SKLDGPERVY TIVGYICETD TIAADRKIKE 350
VKEGDIIAIK NAGAYGYSMS SNYNSRFRPA EVLILNEKDY LIRKRESMED 400
ILKNQISIDF 410
Length:410
Mass (Da):45,651
Last modified:October 19, 2011 - v1
Checksum:i0E0AC58257A72972
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002955 Genomic DNA. Translation: AEL24818.1.
RefSeqiYP_004773049.1. NC_015914.1.

Genome annotation databases

EnsemblBacteriaiAEL24818; AEL24818; Cycma_1046.
GeneIDi11037353.
KEGGicmr:Cycma_1046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002955 Genomic DNA. Translation: AEL24818.1 .
RefSeqi YP_004773049.1. NC_015914.1.

3D structure databases

ProteinModelPortali G0IVQ1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEL24818 ; AEL24818 ; Cycma_1046 .
GeneIDi 11037353.
KEGGi cmr:Cycma_1046.

Phylogenomic databases

KOi K01586.
OMAi SNYNRIG.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00027 .
BioCyci CMAR880070:GHDK-1054-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_02120. LysA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002986. DAP_deCOOHase_LysA.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PRINTSi PR01181. DAPDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01048. lysA. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25205 / DSM 745.

Entry informationi

Entry nameiG0IVQ1_CYCMS
AccessioniPrimary (citable) accession number: G0IVQ1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: July 9, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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