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Protein

Diaminopimelate decarboxylase

Gene

lysA

Organism
Cyclobacterium marinum (strain ATCC 25205 / DSM 745) (Flectobacillus marinus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.UniRule annotation

Catalytic activityi

Meso-2,6-diaminoheptanedioate = L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei227 – 2271Pyridoxal phosphate; via amide nitrogenUniRule annotation
Binding sitei307 – 3071SubstrateUniRule annotation
Binding sitei311 – 3111SubstrateUniRule annotation
Binding sitei338 – 3381SubstrateUniRule annotation
Binding sitei365 – 3651Pyridoxal phosphateUniRule annotation
Binding sitei365 – 3651SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCMAR880070:GHDK-1054-MONOMER.
UniPathwayiUPA00034; UER00027.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate decarboxylaseUniRule annotation (EC:4.1.1.20UniRule annotation)
Short name:
DAP decarboxylaseUniRule annotation
Short name:
DAPDCUniRule annotation
Gene namesi
Name:lysAUniRule annotation
Ordered Locus Names:Cycma_1046Imported
OrganismiCyclobacterium marinum (strain ATCC 25205 / DSM 745) (Flectobacillus marinus)Imported
Taxonomic identifieri880070 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCyclobacteriaceaeCyclobacterium
ProteomesiUP000001635 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei57 – 571N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliG0IVQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.UniRule annotation

Phylogenomic databases

KOiK01586.
OMAiVVGYICE.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_02120. LysA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002986. DAP_deCOOHase_LysA.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01181. DAPDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01048. lysA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G0IVQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIKNQQYCI GGIPLLNIAE KYGSPVYVYD GEKILHQVES LKKAFADVKM
60 70 80 90 100
KIKYATKALS NINILKLMKK AGTGVDAVSI EEVKLCLHVG FSPEEIMYTP
110 120 130 140 150
NCVDFEEIKE AVAYGVMVNI DSIPMLEHFG TEYGNDVPIC IRLNPHILAG
160 170 180 190 200
GNAKISVGHI DSKFGISILQ LKHVIKVVQA YDLNVVGLHV HTGSDILDAE
210 220 230 240 250
VFLQGAEILF DAAREFKDLA FLDFGGGFKV AYKNGDITTD IQDVGKKVSA
260 270 280 290 300
AFKKFCKEYG RELEIWFEPG KFLVSECGYL LTKANVVKPT PATTFVGVNS
310 320 330 340 350
GLNHLLRPMM YDAYHSVVNI SKLDGPERVY TIVGYICETD TIAADRKIKE
360 370 380 390 400
VKEGDIIAIK NAGAYGYSMS SNYNSRFRPA EVLILNEKDY LIRKRESMED
410
ILKNQISIDF
Length:410
Mass (Da):45,651
Last modified:October 19, 2011 - v1
Checksum:i0E0AC58257A72972
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002955 Genomic DNA. Translation: AEL24818.1.
RefSeqiWP_014019115.1. NC_015914.1.
YP_004773049.1. NC_015914.1.

Genome annotation databases

EnsemblBacteriaiAEL24818; AEL24818; Cycma_1046.
KEGGicmr:Cycma_1046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002955 Genomic DNA. Translation: AEL24818.1.
RefSeqiWP_014019115.1. NC_015914.1.
YP_004773049.1. NC_015914.1.

3D structure databases

ProteinModelPortaliG0IVQ1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEL24818; AEL24818; Cycma_1046.
KEGGicmr:Cycma_1046.

Phylogenomic databases

KOiK01586.
OMAiVVGYICE.

Enzyme and pathway databases

UniPathwayiUPA00034; UER00027.
BioCyciCMAR880070:GHDK-1054-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_02120. LysA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002986. DAP_deCOOHase_LysA.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01181. DAPDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01048. lysA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25205 / DSM 745Imported.

Entry informationi

Entry nameiG0IVQ1_CYCMS
AccessioniPrimary (citable) accession number: G0IVQ1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: May 27, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.