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G0IVQ1 (G0IVQ1_CYCMS) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Diaminopimelate decarboxylase HAMAP-Rule MF_02120

Short name=DAP decarboxylase HAMAP-Rule MF_02120
Short name=DAPDC HAMAP-Rule MF_02120
EC=4.1.1.20 HAMAP-Rule MF_02120
Gene names
Name:lysA HAMAP-Rule MF_02120
Ordered Locus Names:Cycma_1046 EMBL AEL24818.1
OrganismCyclobacterium marinum (strain ATCC 25205 / DSM 745) (Flectobacillus marinus) [Complete proteome] [HAMAP] EMBL AEL24818.1
Taxonomic identifier880070 [NCBI]
Taxonomic lineageBacteriaBacteroidetesCytophagiaCytophagalesCyclobacteriaceaeCyclobacterium

Protein attributes

Sequence length410 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine By similarity. HAMAP-Rule MF_02120

Catalytic activity

Meso-2,6-diaminoheptanedioate = L-lysine + CO2. RuleBase RU003738 HAMAP-Rule MF_02120

Cofactor

Pyridoxal phosphate By similarity. RuleBase RU003738 HAMAP-Rule MF_02120 SAAS SAAS022644

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1. RuleBase RU003738 HAMAP-Rule MF_02120

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_02120

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily. HAMAP-Rule MF_02120

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Binding site2271Pyridoxal phosphate; via amide nitrogen By similarity HAMAP-Rule MF_02120
Binding site3071Substrate By similarity HAMAP-Rule MF_02120
Binding site3111Substrate By similarity HAMAP-Rule MF_02120
Binding site3381Substrate By similarity HAMAP-Rule MF_02120
Binding site3651Pyridoxal phosphate By similarity HAMAP-Rule MF_02120
Binding site3651Substrate By similarity HAMAP-Rule MF_02120

Amino acid modifications

Modified residue571N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_02120

Sequences

Sequence LengthMass (Da)Tools
G0IVQ1 [UniParc].

Last modified October 19, 2011. Version 1.
Checksum: 0E0AC58257A72972

FASTA41045,651
        10         20         30         40         50         60 
MEIKNQQYCI GGIPLLNIAE KYGSPVYVYD GEKILHQVES LKKAFADVKM KIKYATKALS 

        70         80         90        100        110        120 
NINILKLMKK AGTGVDAVSI EEVKLCLHVG FSPEEIMYTP NCVDFEEIKE AVAYGVMVNI 

       130        140        150        160        170        180 
DSIPMLEHFG TEYGNDVPIC IRLNPHILAG GNAKISVGHI DSKFGISILQ LKHVIKVVQA 

       190        200        210        220        230        240 
YDLNVVGLHV HTGSDILDAE VFLQGAEILF DAAREFKDLA FLDFGGGFKV AYKNGDITTD 

       250        260        270        280        290        300 
IQDVGKKVSA AFKKFCKEYG RELEIWFEPG KFLVSECGYL LTKANVVKPT PATTFVGVNS 

       310        320        330        340        350        360 
GLNHLLRPMM YDAYHSVVNI SKLDGPERVY TIVGYICETD TIAADRKIKE VKEGDIIAIK 

       370        380        390        400        410 
NAGAYGYSMS SNYNSRFRPA EVLILNEKDY LIRKRESMED ILKNQISIDF 

« Hide

References

[1]"The complete genome of Cyclobacterium marinum DSM 745."
Lucas S., Han J., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L., Kyrpides N., Mavromatis K., Ivanova N., Ovchinnikova G., Chertkov O., Detter J.C., Tapia R., Han C., Land M., Hauser L., Markowitz V. expand/collapse author list , Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Tindall B., Schuetze A., Brambilla E., Klenk H.-P., Eisen J.A.
Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25205 / DSM 745.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002955 Genomic DNA. Translation: AEL24818.1.
RefSeqYP_004773049.1. NC_015914.1.

3D structure databases

ProteinModelPortalG0IVQ1.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEL24818; AEL24818; Cycma_1046.
GeneID11037353.
KEGGcmr:Cycma_1046.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01586.
OMASNYNRIG.

Enzyme and pathway databases

BioCycCMAR880070:GHDK-1054-MONOMER.
UniPathwayUPA00034; UER00027.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPMF_02120. LysA.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002986. DAP_deCOOHase_LysA.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSPR01181. DAPDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR01048. lysA. 1 hit.
PROSITEPS00878. ODR_DC_2_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG0IVQ1_CYCMS
AccessionPrimary (citable) accession number: G0IVQ1
Entry history
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: July 9, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)