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G0IVQ1

- G0IVQ1_CYCMS

UniProt

G0IVQ1 - G0IVQ1_CYCMS

Protein

Diaminopimelate decarboxylase

Gene

lysA

Organism
Cyclobacterium marinum (strain ATCC 25205 / DSM 745) (Flectobacillus marinus)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.UniRule annotation

    Catalytic activityi

    Meso-2,6-diaminoheptanedioate = L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei227 – 2271Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei307 – 3071SubstrateUniRule annotation
    Binding sitei311 – 3111SubstrateUniRule annotation
    Binding sitei338 – 3381SubstrateUniRule annotation
    Binding sitei365 – 3651Pyridoxal phosphateUniRule annotation
    Binding sitei365 – 3651SubstrateUniRule annotation

    GO - Molecular functioni

    1. diaminopimelate decarboxylase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotationSAAS annotation, Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Lysine biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCMAR880070:GHDK-1054-MONOMER.
    UniPathwayiUPA00034; UER00027.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diaminopimelate decarboxylaseUniRule annotation (EC:4.1.1.20UniRule annotation)
    Short name:
    DAP decarboxylaseUniRule annotation
    Short name:
    DAPDCUniRule annotation
    Gene namesi
    Name:lysAUniRule annotation
    Ordered Locus Names:Cycma_1046Imported
    OrganismiCyclobacterium marinum (strain ATCC 25205 / DSM 745) (Flectobacillus marinus)Imported
    Taxonomic identifieri880070 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCyclobacteriaceaeCyclobacterium
    ProteomesiUP000001635: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei57 – 571N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliG0IVQ1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.UniRule annotation

    Phylogenomic databases

    KOiK01586.
    OMAiSNYNRIG.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_02120. LysA.
    InterProiIPR009006. Ala_racemase/Decarboxylase_C.
    IPR002986. DAP_deCOOHase_LysA.
    IPR022643. De-COase2_C.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view]
    PRINTSiPR01181. DAPDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR01048. lysA. 1 hit.
    PROSITEiPS00878. ODR_DC_2_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G0IVQ1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEIKNQQYCI GGIPLLNIAE KYGSPVYVYD GEKILHQVES LKKAFADVKM    50
    KIKYATKALS NINILKLMKK AGTGVDAVSI EEVKLCLHVG FSPEEIMYTP 100
    NCVDFEEIKE AVAYGVMVNI DSIPMLEHFG TEYGNDVPIC IRLNPHILAG 150
    GNAKISVGHI DSKFGISILQ LKHVIKVVQA YDLNVVGLHV HTGSDILDAE 200
    VFLQGAEILF DAAREFKDLA FLDFGGGFKV AYKNGDITTD IQDVGKKVSA 250
    AFKKFCKEYG RELEIWFEPG KFLVSECGYL LTKANVVKPT PATTFVGVNS 300
    GLNHLLRPMM YDAYHSVVNI SKLDGPERVY TIVGYICETD TIAADRKIKE 350
    VKEGDIIAIK NAGAYGYSMS SNYNSRFRPA EVLILNEKDY LIRKRESMED 400
    ILKNQISIDF 410
    Length:410
    Mass (Da):45,651
    Last modified:October 19, 2011 - v1
    Checksum:i0E0AC58257A72972
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002955 Genomic DNA. Translation: AEL24818.1.
    RefSeqiYP_004773049.1. NC_015914.1.

    Genome annotation databases

    EnsemblBacteriaiAEL24818; AEL24818; Cycma_1046.
    GeneIDi11037353.
    KEGGicmr:Cycma_1046.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002955 Genomic DNA. Translation: AEL24818.1 .
    RefSeqi YP_004773049.1. NC_015914.1.

    3D structure databases

    ProteinModelPortali G0IVQ1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEL24818 ; AEL24818 ; Cycma_1046 .
    GeneIDi 11037353.
    KEGGi cmr:Cycma_1046.

    Phylogenomic databases

    KOi K01586.
    OMAi SNYNRIG.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00027 .
    BioCyci CMAR880070:GHDK-1054-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_02120. LysA.
    InterProi IPR009006. Ala_racemase/Decarboxylase_C.
    IPR002986. DAP_deCOOHase_LysA.
    IPR022643. De-COase2_C.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view ]
    PRINTSi PR01181. DAPDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR01048. lysA. 1 hit.
    PROSITEi PS00878. ODR_DC_2_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25205 / DSM 745Imported.

    Entry informationi

    Entry nameiG0IVQ1_CYCMS
    AccessioniPrimary (citable) accession number: G0IVQ1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 19, 2011
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3