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G0IVQ1

- G0IVQ1_CYCMS

UniProt

G0IVQ1 - G0IVQ1_CYCMS

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Protein

Diaminopimelate decarboxylase

Gene

lysA

Organism
Cyclobacterium marinum (strain ATCC 25205 / DSM 745) (Flectobacillus marinus)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.UniRule annotation

Catalytic activityi

Meso-2,6-diaminoheptanedioate = L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei227 – 2271Pyridoxal phosphate; via amide nitrogenUniRule annotation
Binding sitei307 – 3071SubstrateUniRule annotation
Binding sitei311 – 3111SubstrateUniRule annotation
Binding sitei338 – 3381SubstrateUniRule annotation
Binding sitei365 – 3651Pyridoxal phosphateUniRule annotation
Binding sitei365 – 3651SubstrateUniRule annotation

GO - Molecular functioni

  1. diaminopimelate decarboxylase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCMAR880070:GHDK-1054-MONOMER.
UniPathwayiUPA00034; UER00027.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate decarboxylaseUniRule annotation (EC:4.1.1.20UniRule annotation)
Short name:
DAP decarboxylaseUniRule annotation
Short name:
DAPDCUniRule annotation
Gene namesi
Name:lysAUniRule annotation
Ordered Locus Names:Cycma_1046Imported
OrganismiCyclobacterium marinum (strain ATCC 25205 / DSM 745) (Flectobacillus marinus)Imported
Taxonomic identifieri880070 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCyclobacteriaceaeCyclobacterium
ProteomesiUP000001635: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei57 – 571N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliG0IVQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.UniRule annotation

Phylogenomic databases

KOiK01586.
OMAiSNYNRIG.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_02120. LysA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002986. DAP_deCOOHase_LysA.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01181. DAPDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01048. lysA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G0IVQ1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEIKNQQYCI GGIPLLNIAE KYGSPVYVYD GEKILHQVES LKKAFADVKM
60 70 80 90 100
KIKYATKALS NINILKLMKK AGTGVDAVSI EEVKLCLHVG FSPEEIMYTP
110 120 130 140 150
NCVDFEEIKE AVAYGVMVNI DSIPMLEHFG TEYGNDVPIC IRLNPHILAG
160 170 180 190 200
GNAKISVGHI DSKFGISILQ LKHVIKVVQA YDLNVVGLHV HTGSDILDAE
210 220 230 240 250
VFLQGAEILF DAAREFKDLA FLDFGGGFKV AYKNGDITTD IQDVGKKVSA
260 270 280 290 300
AFKKFCKEYG RELEIWFEPG KFLVSECGYL LTKANVVKPT PATTFVGVNS
310 320 330 340 350
GLNHLLRPMM YDAYHSVVNI SKLDGPERVY TIVGYICETD TIAADRKIKE
360 370 380 390 400
VKEGDIIAIK NAGAYGYSMS SNYNSRFRPA EVLILNEKDY LIRKRESMED
410
ILKNQISIDF
Length:410
Mass (Da):45,651
Last modified:October 19, 2011 - v1
Checksum:i0E0AC58257A72972
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002955 Genomic DNA. Translation: AEL24818.1.
RefSeqiWP_014019115.1. NC_015914.1.
YP_004773049.1. NC_015914.1.

Genome annotation databases

EnsemblBacteriaiAEL24818; AEL24818; Cycma_1046.
GeneIDi11037353.
KEGGicmr:Cycma_1046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002955 Genomic DNA. Translation: AEL24818.1 .
RefSeqi WP_014019115.1. NC_015914.1.
YP_004773049.1. NC_015914.1.

3D structure databases

ProteinModelPortali G0IVQ1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEL24818 ; AEL24818 ; Cycma_1046 .
GeneIDi 11037353.
KEGGi cmr:Cycma_1046.

Phylogenomic databases

KOi K01586.
OMAi SNYNRIG.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00027 .
BioCyci CMAR880070:GHDK-1054-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_02120. LysA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002986. DAP_deCOOHase_LysA.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PRINTSi PR01181. DAPDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01048. lysA. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25205 / DSM 745Imported.

Entry informationi

Entry nameiG0IVQ1_CYCMS
AccessioniPrimary (citable) accession number: G0IVQ1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: October 29, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3