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Protein

DNA ligase

Gene

lig2

Organism
Haloarcula hispanica (strain ATCC 33960 / DSM 4426 / JCM 8911 / NBRC 102182 / NCIMB 2187 / VKM B-1755)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei253ATPUniRule annotation1
Active sitei255N6-AMP-lysine intermediateUniRule annotation1
Binding sitei260ATPUniRule annotation1
Binding sitei275ATPUniRule annotation1
Binding sitei304ATPUniRule annotation1
Binding sitei344ATPUniRule annotation1
Binding sitei418ATPUniRule annotation1
Binding sitei424ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:lig2Imported
Synonyms:ligUniRule annotation
Ordered Locus Names:HAH_1173Imported
OrganismiHaloarcula hispanica (strain ATCC 33960 / DSM 4426 / JCM 8911 / NBRC 102182 / NCIMB 2187 / VKM B-1755)Imported
Taxonomic identifieri634497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHaloarculaceaeHaloarcula
Proteomesi
  • UP000005629 Componenti: Chromosome I

Interactioni

Protein-protein interaction databases

STRINGi634497.HAH_1173

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini332 – 459DNA_LIGASE_A3InterPro annotationAdd BLAST128

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili382 – 402Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
KOiK10747
OMAiWLFEESY
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

G0HXQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFAAFADRA EKIEAESADT AITEAVTALL TDAGPDLSTL ARFVQGRVFP
60 70 80 90 100
SYESRTLDIG PRLCYEAIAR AAGQNVSTDD VEQRLADLGE IGAVAASYDL
110 120 130 140 150
GGQQGLAAFG AGGGGDDALT VAELDDELRN LAAVDGSGSQ GTKVDILFGL
160 170 180 190 200
FSRCSSTEAG YLARLVLSEM RIGVGEGTVR DAVAAAFDVP VEAVERAVQV
210 220 230 240 250
SNDYGMVAEV ARDEGESGLA TVTLEIGRPV QAMLAQAGTV AGALEDWDRA
260 270 280 290 300
AVEWKYDGAR VQVHFDGEDA RLFSRNMEEV TDPLPEVVDT VESTLDAPAI
310 320 330 340 350
LDGEVVAVDA DGDPLPFQEV LRRFRRKHDV AAAREDVAVR LHAFDCLHAD
360 370 380 390 400
GEDLLDASLK TRHDRLESLL PAGSDVVSRM WLSDDAEEIE NLEAEALAAG
410 420 430 440 450
QEGIMLKDPT AAYSPGKRGK HWRKRKPDVE TLDCVVTGAE WGEGRRANVL
460 470 480 490 500
GSFELSVRTD DGYATVGNVA TGITDEELDD LTERFEPHIR REDGRDVALD
510 520 530 540 550
PAIVFEVGYE EIQASQSYAS GYALRFPRFL SVREDKTPAG ADSLERVERL

AASQ
Length:554
Mass (Da):59,543
Last modified:October 19, 2011 - v1
Checksum:iAE3D39BE70606545
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002921 Genomic DNA Translation: AEM56788.1
RefSeqiWP_014040060.1, NC_015948.1

Genome annotation databases

EnsemblBacteriaiAEM56788; AEM56788; HAH_1173
GeneIDi23805466
KEGGihhi:HAH_1173

Similar proteinsi

Entry informationi

Entry nameiG0HXQ6_HALHT
AccessioniPrimary (citable) accession number: G0HXQ6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: March 28, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health