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G0HXQ6

- G0HXQ6_HALHT

UniProt

G0HXQ6 - G0HXQ6_HALHT

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Protein

DNA ligase

Gene

lig2

Organism
Haloarcula hispanica (strain ATCC 33960 / DSM 4426 / JCM 8911 / NBRC 102182 / NCIMB 2187 / VKM B-1755)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Note: Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei253 – 2531ATPUniRule annotation
Active sitei255 – 2551N6-AMP-lysine intermediateUniRule annotation
Binding sitei260 – 2601ATPUniRule annotation
Binding sitei275 – 2751ATPUniRule annotation
Binding sitei304 – 3041ATPUniRule annotation
Binding sitei344 – 3441ATPUniRule annotation
Binding sitei418 – 4181ATPUniRule annotation
Binding sitei424 – 4241ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciHHIS634497:GIY3-1171-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:lig2Imported
Synonyms:ligUniRule annotation
Ordered Locus Names:HAH_1173Imported
OrganismiHaloarcula hispanica (strain ATCC 33960 / DSM 4426 / JCM 8911 / NBRC 102182 / NCIMB 2187 / VKM B-1755)Imported
Taxonomic identifieri634497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
ProteomesiUP000005629: Chromosome I

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G0HXQ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFAAFADRA EKIEAESADT AITEAVTALL TDAGPDLSTL ARFVQGRVFP
60 70 80 90 100
SYESRTLDIG PRLCYEAIAR AAGQNVSTDD VEQRLADLGE IGAVAASYDL
110 120 130 140 150
GGQQGLAAFG AGGGGDDALT VAELDDELRN LAAVDGSGSQ GTKVDILFGL
160 170 180 190 200
FSRCSSTEAG YLARLVLSEM RIGVGEGTVR DAVAAAFDVP VEAVERAVQV
210 220 230 240 250
SNDYGMVAEV ARDEGESGLA TVTLEIGRPV QAMLAQAGTV AGALEDWDRA
260 270 280 290 300
AVEWKYDGAR VQVHFDGEDA RLFSRNMEEV TDPLPEVVDT VESTLDAPAI
310 320 330 340 350
LDGEVVAVDA DGDPLPFQEV LRRFRRKHDV AAAREDVAVR LHAFDCLHAD
360 370 380 390 400
GEDLLDASLK TRHDRLESLL PAGSDVVSRM WLSDDAEEIE NLEAEALAAG
410 420 430 440 450
QEGIMLKDPT AAYSPGKRGK HWRKRKPDVE TLDCVVTGAE WGEGRRANVL
460 470 480 490 500
GSFELSVRTD DGYATVGNVA TGITDEELDD LTERFEPHIR REDGRDVALD
510 520 530 540 550
PAIVFEVGYE EIQASQSYAS GYALRFPRFL SVREDKTPAG ADSLERVERL

AASQ
Length:554
Mass (Da):59,543
Last modified:October 19, 2011 - v1
Checksum:iAE3D39BE70606545
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002921 Genomic DNA. Translation: AEM56788.1.
RefSeqiYP_004795776.1. NC_015948.1.

Genome annotation databases

EnsemblBacteriaiAEM56788; AEM56788; HAH_1173.
GeneIDi11050051.
KEGGihhi:HAH_1173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002921 Genomic DNA. Translation: AEM56788.1 .
RefSeqi YP_004795776.1. NC_015948.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEM56788 ; AEM56788 ; HAH_1173 .
GeneIDi 11050051.
KEGGi hhi:HAH_1173.

Phylogenomic databases

KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci HHIS634497:GIY3-1171-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Haloarcula hispanica, a model haloarchaeon for studying genetics, metabolism, and virus-host interaction."
    Liu H., Wu Z., Li M., Zhang F., Zheng H., Han J., Liu J., Zhou J., Wang S., Xiang H.
    J. Bacteriol. 193:6086-6087(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33960 / DSM 4426 / JCM 8911 / NBRC 102182 / NCIMB 2187 / VKM B-1755Imported.

Entry informationi

Entry nameiG0HXQ6_HALHT
AccessioniPrimary (citable) accession number: G0HXQ6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: November 26, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3