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G0HXQ6

- G0HXQ6_HALHT

UniProt

G0HXQ6 - G0HXQ6_HALHT

Protein

DNA ligase

Gene

lig2

Organism
Haloarcula hispanica (strain ATCC 33960 / DSM 4426 / JCM 8911 / NBRC 102182 / NCIMB 2187 / VKM B-1755)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei253 – 2531ATPUniRule annotation
    Active sitei255 – 2551N6-AMP-lysine intermediateUniRule annotation
    Binding sitei260 – 2601ATPUniRule annotation
    Binding sitei275 – 2751ATPUniRule annotation
    Binding sitei304 – 3041ATPUniRule annotation
    Binding sitei344 – 3441ATPUniRule annotation
    Binding sitei418 – 4181ATPUniRule annotation
    Binding sitei424 – 4241ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHHIS634497:GIY3-1171-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:lig2Imported
    Synonyms:ligUniRule annotation
    Ordered Locus Names:HAH_1173Imported
    OrganismiHaloarcula hispanica (strain ATCC 33960 / DSM 4426 / JCM 8911 / NBRC 102182 / NCIMB 2187 / VKM B-1755)Imported
    Taxonomic identifieri634497 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
    ProteomesiUP000005629: Chromosome I

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10747.
    OMAiARVQVHK.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G0HXQ6-1 [UniParc]FASTAAdd to Basket

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    MEFAAFADRA EKIEAESADT AITEAVTALL TDAGPDLSTL ARFVQGRVFP    50
    SYESRTLDIG PRLCYEAIAR AAGQNVSTDD VEQRLADLGE IGAVAASYDL 100
    GGQQGLAAFG AGGGGDDALT VAELDDELRN LAAVDGSGSQ GTKVDILFGL 150
    FSRCSSTEAG YLARLVLSEM RIGVGEGTVR DAVAAAFDVP VEAVERAVQV 200
    SNDYGMVAEV ARDEGESGLA TVTLEIGRPV QAMLAQAGTV AGALEDWDRA 250
    AVEWKYDGAR VQVHFDGEDA RLFSRNMEEV TDPLPEVVDT VESTLDAPAI 300
    LDGEVVAVDA DGDPLPFQEV LRRFRRKHDV AAAREDVAVR LHAFDCLHAD 350
    GEDLLDASLK TRHDRLESLL PAGSDVVSRM WLSDDAEEIE NLEAEALAAG 400
    QEGIMLKDPT AAYSPGKRGK HWRKRKPDVE TLDCVVTGAE WGEGRRANVL 450
    GSFELSVRTD DGYATVGNVA TGITDEELDD LTERFEPHIR REDGRDVALD 500
    PAIVFEVGYE EIQASQSYAS GYALRFPRFL SVREDKTPAG ADSLERVERL 550
    AASQ 554
    Length:554
    Mass (Da):59,543
    Last modified:October 19, 2011 - v1
    Checksum:iAE3D39BE70606545
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002921 Genomic DNA. Translation: AEM56788.1.
    RefSeqiYP_004795776.1. NC_015948.1.

    Genome annotation databases

    EnsemblBacteriaiAEM56788; AEM56788; HAH_1173.
    GeneIDi11050051.
    KEGGihhi:HAH_1173.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002921 Genomic DNA. Translation: AEM56788.1 .
    RefSeqi YP_004795776.1. NC_015948.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEM56788 ; AEM56788 ; HAH_1173 .
    GeneIDi 11050051.
    KEGGi hhi:HAH_1173.

    Phylogenomic databases

    KOi K10747.
    OMAi ARVQVHK.

    Enzyme and pathway databases

    BioCyci HHIS634497:GIY3-1171-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Haloarcula hispanica, a model haloarchaeon for studying genetics, metabolism, and virus-host interaction."
      Liu H., Wu Z., Li M., Zhang F., Zheng H., Han J., Liu J., Zhou J., Wang S., Xiang H.
      J. Bacteriol. 193:6086-6087(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33960 / DSM 4426 / JCM 8911 / NBRC 102182 / NCIMB 2187 / VKM B-1755Imported.

    Entry informationi

    Entry nameiG0HXQ6_HALHT
    AccessioniPrimary (citable) accession number: G0HXQ6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 19, 2011
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3