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G0HXQ6

- G0HXQ6_HALHT

UniProt

G0HXQ6 - G0HXQ6_HALHT

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Protein
DNA ligase
Gene
lig2, lig, HAH_1173
Organism
Haloarcula hispanica (strain ATCC 33960 / DSM 4426 / JCM 8911 / NBRC 102182 / NCIMB 2187 / VKM B-1755)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei253 – 2531ATP By similarityUniRule annotation
Active sitei255 – 2551N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei260 – 2601ATP By similarityUniRule annotation
Binding sitei275 – 2751ATP By similarityUniRule annotation
Binding sitei304 – 3041ATP By similarityUniRule annotation
Binding sitei344 – 3441ATP By similarityUniRule annotation
Binding sitei418 – 4181ATP By similarityUniRule annotation
Binding sitei424 – 4241ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciHHIS634497:GIY3-1171-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig2Imported
Synonyms:ligUniRule annotation
Ordered Locus Names:HAH_1173Imported
OrganismiHaloarcula hispanica (strain ATCC 33960 / DSM 4426 / JCM 8911 / NBRC 102182 / NCIMB 2187 / VKM B-1755)Imported
Taxonomic identifieri634497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
ProteomesiUP000005629: Chromosome I

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G0HXQ6-1 [UniParc]FASTAAdd to Basket

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MEFAAFADRA EKIEAESADT AITEAVTALL TDAGPDLSTL ARFVQGRVFP    50
SYESRTLDIG PRLCYEAIAR AAGQNVSTDD VEQRLADLGE IGAVAASYDL 100
GGQQGLAAFG AGGGGDDALT VAELDDELRN LAAVDGSGSQ GTKVDILFGL 150
FSRCSSTEAG YLARLVLSEM RIGVGEGTVR DAVAAAFDVP VEAVERAVQV 200
SNDYGMVAEV ARDEGESGLA TVTLEIGRPV QAMLAQAGTV AGALEDWDRA 250
AVEWKYDGAR VQVHFDGEDA RLFSRNMEEV TDPLPEVVDT VESTLDAPAI 300
LDGEVVAVDA DGDPLPFQEV LRRFRRKHDV AAAREDVAVR LHAFDCLHAD 350
GEDLLDASLK TRHDRLESLL PAGSDVVSRM WLSDDAEEIE NLEAEALAAG 400
QEGIMLKDPT AAYSPGKRGK HWRKRKPDVE TLDCVVTGAE WGEGRRANVL 450
GSFELSVRTD DGYATVGNVA TGITDEELDD LTERFEPHIR REDGRDVALD 500
PAIVFEVGYE EIQASQSYAS GYALRFPRFL SVREDKTPAG ADSLERVERL 550
AASQ 554
Length:554
Mass (Da):59,543
Last modified:October 19, 2011 - v1
Checksum:iAE3D39BE70606545
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002921 Genomic DNA. Translation: AEM56788.1.
RefSeqiYP_004795776.1. NC_015948.1.

Genome annotation databases

EnsemblBacteriaiAEM56788; AEM56788; HAH_1173.
GeneIDi11050051.
KEGGihhi:HAH_1173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002921 Genomic DNA. Translation: AEM56788.1 .
RefSeqi YP_004795776.1. NC_015948.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEM56788 ; AEM56788 ; HAH_1173 .
GeneIDi 11050051.
KEGGi hhi:HAH_1173.

Phylogenomic databases

KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci HHIS634497:GIY3-1171-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Haloarcula hispanica, a model haloarchaeon for studying genetics, metabolism, and virus-host interaction."
    Liu H., Wu Z., Li M., Zhang F., Zheng H., Han J., Liu J., Zhou J., Wang S., Xiang H.
    J. Bacteriol. 193:6086-6087(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33960 / DSM 4426 / JCM 8911 / NBRC 102182 / NCIMB 2187 / VKM B-1755.

Entry informationi

Entry nameiG0HXQ6_HALHT
AccessioniPrimary (citable) accession number: G0HXQ6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: June 11, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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