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G0HXQ6 (G0HXQ6_HALHT) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA ligase RuleBase RU000617 HAMAP-Rule MF_00407
EC=6.5.1.1 RuleBase RU000617 HAMAP-Rule MF_00407
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] HAMAP-Rule MF_00407
Gene names
Name:lig2 EMBL AEM56788.1
Synonyms:lig HAMAP-Rule MF_00407
Ordered Locus Names:HAH_1173 EMBL AEM56788.1
OrganismHaloarcula hispanica (strain ATCC 33960 / DSM 4426 / JCM 8911 / NBRC 102182 / NCIMB 2187 / VKM B-1755) [Complete proteome] [HAMAP]
Taxonomic identifier634497 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloarcula ›

Protein attributes

Sequence length554 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). RuleBase RU000617 HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. HAMAP-Rule MF_00407 RuleBase RU004196

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2551N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2531ATP By similarity HAMAP-Rule MF_00407
Binding site2601ATP By similarity HAMAP-Rule MF_00407
Binding site2751ATP By similarity HAMAP-Rule MF_00407
Binding site3041ATP By similarity HAMAP-Rule MF_00407
Binding site3441ATP By similarity HAMAP-Rule MF_00407
Binding site4181ATP By similarity HAMAP-Rule MF_00407
Binding site4241ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
G0HXQ6 [UniParc].

Last modified October 19, 2011. Version 1.
Checksum: AE3D39BE70606545

FASTA55459,543
        10         20         30         40         50         60 
MEFAAFADRA EKIEAESADT AITEAVTALL TDAGPDLSTL ARFVQGRVFP SYESRTLDIG 

        70         80         90        100        110        120 
PRLCYEAIAR AAGQNVSTDD VEQRLADLGE IGAVAASYDL GGQQGLAAFG AGGGGDDALT 

       130        140        150        160        170        180 
VAELDDELRN LAAVDGSGSQ GTKVDILFGL FSRCSSTEAG YLARLVLSEM RIGVGEGTVR 

       190        200        210        220        230        240 
DAVAAAFDVP VEAVERAVQV SNDYGMVAEV ARDEGESGLA TVTLEIGRPV QAMLAQAGTV 

       250        260        270        280        290        300 
AGALEDWDRA AVEWKYDGAR VQVHFDGEDA RLFSRNMEEV TDPLPEVVDT VESTLDAPAI 

       310        320        330        340        350        360 
LDGEVVAVDA DGDPLPFQEV LRRFRRKHDV AAAREDVAVR LHAFDCLHAD GEDLLDASLK 

       370        380        390        400        410        420 
TRHDRLESLL PAGSDVVSRM WLSDDAEEIE NLEAEALAAG QEGIMLKDPT AAYSPGKRGK 

       430        440        450        460        470        480 
HWRKRKPDVE TLDCVVTGAE WGEGRRANVL GSFELSVRTD DGYATVGNVA TGITDEELDD 

       490        500        510        520        530        540 
LTERFEPHIR REDGRDVALD PAIVFEVGYE EIQASQSYAS GYALRFPRFL SVREDKTPAG 

       550 
ADSLERVERL AASQ

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References

[1]"Complete genome sequence of Haloarcula hispanica, a model haloarchaeon for studying genetics, metabolism, and virus-host interaction."
Liu H., Wu Z., Li M., Zhang F., Zheng H., Han J., Liu J., Zhou J., Wang S., Xiang H.
J. Bacteriol. 193:6086-6087(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33960 / DSM 4426 / JCM 8911 / NBRC 102182 / NCIMB 2187 / VKM B-1755.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002921 Genomic DNA. Translation: AEM56788.1.
RefSeqYP_004795776.1. NC_015948.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEM56788; AEM56788; HAH_1173.
GeneID11050051.
KEGGhhi:HAH_1173.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK10747.

Enzyme and pathway databases

BioCycHHIS634497:GIY3-1171-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF50249. Nucleic_acid_OB. 1 hit.
SSF117018. SSF117018. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG0HXQ6_HALHT
AccessionPrimary (citable) accession number: G0HXQ6
Entry history
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: April 3, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info