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Protein

Phosphoenolpyruvate carboxylase

Gene

ppcA

Organism
Thermococcus sp. (strain CGMCC 1.5172 / 4557)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

BioCyciTSP1042877:GHEX-2162-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcAUniRule annotation
Ordered Locus Names:GQS_10630Imported
OrganismiThermococcus sp. (strain CGMCC 1.5172 / 4557)Imported
Taxonomic identifieri1042877 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000000874 Componenti: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 2 family.UniRule annotation

Phylogenomic databases

KOiK01595.
OMAiQSSFKYD.

Family and domain databases

HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

G0HPP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPRTMSTQH PDNVFIPFFA GSPTMGGEDE VIEAFYAFSV LGIDEQMWDF
60 70 80 90 100
EGKEVDEFVV KKLFERYGYF FKRKKLGEEL RLTPRVPNPS VERAEAKLLL
110 120 130 140 150
ETLEAIPRSA DYARLFYGEE LPPIFEVILP MTTSSQELNR VYELYRHYIA
160 170 180 190 200
GKQYKRVHDI KLHEWIGEFY PSEIGVIPLF ESREAILSAA DIVREYLGGK
210 220 230 240 250
EVEYQRVFLA RSDPAMNYGL ISAVLYDKLA LFELQGLEEE LGIPIYPIIG
260 270 280 290 300
VGGAPFRGHF TPENVEGVLA EYPSVQTFTI QSSFKYDRTP KDVIRAVERI
310 320 330 340 350
RESKRGKALP VPEEAFEILK KYEARYSEEL RALAPFIREV AKFVPSRRRR
360 370 380 390 400
KLHIGLFGYS REVNGSALPR AIKFTASLYS LGIPPELLGL SALSEKELEF
410 420 430 440 450
LGDYYLDLYR DIEFAFRYFN PKAAERFPFL KPLAKMARDY ERDERHGEIT
460 470
SRILAGELSS ELIVEAAGIR GFLG
Length:474
Mass (Da):54,418
Last modified:October 19, 2011 - v1
Checksum:iEAE01A04E1D9ACE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002920 Genomic DNA. Translation: AEK74019.1.
RefSeqiWP_014013701.1. NC_015865.1.
YP_004763696.1. NC_015865.1.

Genome annotation databases

EnsemblBacteriaiAEK74019; AEK74019; GQS_10630.
GeneIDi11016810.
KEGGithe:GQS_10630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002920 Genomic DNA. Translation: AEK74019.1.
RefSeqiWP_014013701.1. NC_015865.1.
YP_004763696.1. NC_015865.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEK74019; AEK74019; GQS_10630.
GeneIDi11016810.
KEGGithe:GQS_10630.

Phylogenomic databases

KOiK01595.
OMAiQSSFKYD.

Enzyme and pathway databases

BioCyciTSP1042877:GHEX-2162-MONOMER.

Family and domain databases

HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Thermococcus sp. strain 4557, a hyperthermophilic archaeon isolated from a deep-sea hydrothermal vent area."
    Wang X., Gao Z., Xu X., Ruan L.
    J. Bacteriol. 193:5544-5545(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CGMCC 1.5172 / 4557Imported.

Entry informationi

Entry nameiG0HPP9_THES4
AccessioniPrimary (citable) accession number: G0HPP9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: January 7, 2015
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.