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Protein

Thymidine kinase

Gene

tdk

Organism
Thermococcus sp. (strain CGMCC 1.5172 / 4557)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei92Proton acceptorUniRule annotation1
Metal bindingi148ZincUniRule annotation1
Metal bindingi151ZincUniRule annotation1
Metal bindingi186ZincUniRule annotation1
Metal bindingi189ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 20ATPUniRule annotation8
Nucleotide bindingi91 – 94ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:GQS_09495Imported
OrganismiThermococcus sp. (strain CGMCC 1.5172 / 4557)Imported
Taxonomic identifieri1042877 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000000874 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi1042877.GQS_09495.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04798. Archaea.
COG1435. LUCA.
KOiK00857.
OMAiKEQFGWI.
OrthoDBiPOG093Z0AT6.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiView protein in Pfam
PF00265. TK. 1 hit.
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00603. TK_CELLULAR_TYPE. 1 hit.

Sequencei

Sequence statusi: Complete.

G0HNE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHPGGFLEV ITGPMFAGKT TELIKRIERQ TFAKRKAALF KPSIDNRYSE
60 70 80 90 100
DDVVAHNGLR YEAFVVPTNE EGVELIERIT LDEGFEVIGV DEVQFFPQVI
110 120 130 140 150
VETLNRLADE GIYVIASGLN LDFKGDPFPV TRDLLVRADN IVYLTAVCTV
160 170 180 190
CGKPATRSQR LIDGKPAPRD SPIILVGSSE SYEARCREHH FVP
Length:193
Mass (Da):21,520
Last modified:October 19, 2011 - v1
Checksum:i649C7BB9C1F9AAE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002920 Genomic DNA. Translation: AEK73793.1.
RefSeqiWP_014013475.1. NC_015865.1.

Genome annotation databases

EnsemblBacteriaiAEK73793; AEK73793; GQS_09495.
GeneIDi11016581.
KEGGithe:GQS_09495.
PATRICifig|1042877.9.peg.1852.

Similar proteinsi

Entry informationi

Entry nameiG0HNE2_THES4
AccessioniPrimary (citable) accession number: G0HNE2
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: September 27, 2017
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported