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G0HNE2

- G0HNE2_THES4

UniProt

G0HNE2 - G0HNE2_THES4

Protein

Thymidine kinase

Gene

tdk

Organism
Thermococcus sp. (strain CGMCC 1.5172 / 4557)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei92 – 921Proton acceptorUniRule annotation
    Metal bindingi148 – 1481ZincUniRule annotation
    Metal bindingi151 – 1511ZincUniRule annotation
    Metal bindingi186 – 1861ZincUniRule annotation
    Metal bindingi189 – 1891ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 208ATPUniRule annotation
    Nucleotide bindingi91 – 944ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

    Enzyme and pathway databases

    BioCyciTSP1042877:GHEX-1933-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:GQS_09495Imported
    OrganismiThermococcus sp. (strain CGMCC 1.5172 / 4557)Imported
    Taxonomic identifieri1042877 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
    ProteomesiUP000000874: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    KOiK00857.
    OMAiDHISEST.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G0HNE2-1 [UniParc]FASTAAdd to Basket

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    MVHPGGFLEV ITGPMFAGKT TELIKRIERQ TFAKRKAALF KPSIDNRYSE    50
    DDVVAHNGLR YEAFVVPTNE EGVELIERIT LDEGFEVIGV DEVQFFPQVI 100
    VETLNRLADE GIYVIASGLN LDFKGDPFPV TRDLLVRADN IVYLTAVCTV 150
    CGKPATRSQR LIDGKPAPRD SPIILVGSSE SYEARCREHH FVP 193
    Length:193
    Mass (Da):21,520
    Last modified:October 19, 2011 - v1
    Checksum:i649C7BB9C1F9AAE6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002920 Genomic DNA. Translation: AEK73793.1.
    RefSeqiWP_014013475.1. NC_015865.1.
    YP_004763470.1. NC_015865.1.

    Genome annotation databases

    EnsemblBacteriaiAEK73793; AEK73793; GQS_09495.
    GeneIDi11016581.
    KEGGithe:GQS_09495.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002920 Genomic DNA. Translation: AEK73793.1 .
    RefSeqi WP_014013475.1. NC_015865.1.
    YP_004763470.1. NC_015865.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEK73793 ; AEK73793 ; GQS_09495 .
    GeneIDi 11016581.
    KEGGi the:GQS_09495.

    Phylogenomic databases

    KOi K00857.
    OMAi DHISEST.

    Enzyme and pathway databases

    BioCyci TSP1042877:GHEX-1933-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Thermococcus sp. strain 4557, a hyperthermophilic archaeon isolated from a deep-sea hydrothermal vent area."
      Wang X., Gao Z., Xu X., Ruan L.
      J. Bacteriol. 193:5544-5545(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CGMCC 1.5172 / 4557Imported.

    Entry informationi

    Entry nameiG0HNE2_THES4
    AccessioniPrimary (citable) accession number: G0HNE2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 19, 2011
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3