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G0HNE1

- G0HNE1_THES4

UniProt

G0HNE1 - G0HNE1_THES4

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Protein

Ribulose bisphosphate carboxylase

Gene

rbcL

Organism
Thermococcus sp. (strain CGMCC 1.5172 / 4557)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Note: Binds 1 magnesium ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei163 – 1631Proton acceptorUniRule annotation
Binding sitei165 – 1651SubstrateUniRule annotation
Metal bindingi189 – 1891Magnesium; via carbamate groupUniRule annotation
Metal bindingi191 – 1911MagnesiumUniRule annotation
Metal bindingi192 – 1921MagnesiumUniRule annotation
Active sitei281 – 2811Proton acceptorUniRule annotation
Binding sitei282 – 2821SubstrateUniRule annotation
Binding sitei314 – 3141SubstrateUniRule annotation
Sitei322 – 3221Transition state stabilizerUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. oxidoreductase activity Source: UniProtKB-KW
  3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. AMP catabolic process Source: UniProtKB-HAMAP
  2. carbon fixation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported, OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciTSP1042877:GHEX-1932-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotationImported
Ordered Locus Names:GQS_09490Imported
OrganismiThermococcus sp. (strain CGMCC 1.5172 / 4557)Imported
Taxonomic identifieri1042877 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000000874: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei189 – 1891N6-carboxylysineUniRule annotation

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliG0HNE1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni367 – 3693Substrate bindingUniRule annotation
Regioni389 – 3924Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the RuBisCO large chain family. Type III subfamily.UniRule annotation

Phylogenomic databases

KOiK01601.
OMAiFTQDWAS.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01133. RuBisCO_L_type3.
InterProiIPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.

Sequencei

Sequence statusi: Complete.

G0HNE1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVEKFDEIYD YYVDKAYEPN KKRDIIAVFR ITPAKGYTIE AAAGAVAAES
60 70 80 90 100
STGTWTTLYE WYEKERWADL SAKAYDFHDM GDGSWIVKIA YPSHAFEDGN
110 120 130 140 150
MPGFLASIAG NIFGMKRVEW LRLEDIYLPE RFLRNYPGPN FGIEGVRKKL
160 170 180 190 200
EIYDRPLYGV VPKPKVGYSP EELYKLANDL FLGGADYIKD DENLTSPWYN
210 220 230 240 250
RFEERVKIVT KAMERAENET GEKKTWFANI TAPILEMEER LEILADYGVP
260 270 280 290 300
HAMIDVVVLG WGVLDYIREL ADDYGIALHA HRAMHTAFAR NPYHGISMFV
310 320 330 340 350
LAKLYRLIGV DQLHIGTAGA GKMEGEKWEV IQYKRIITED HYVPDENDVF
360 370 380 390 400
HLEQKFYHIK PVFPTSSGGL HPGNIQPVID ALGKDIVLQL GGGTMGHPDG
410 420 430 440
PKAGAMAVRQ ALDAIMQGIP LDEYAKSHRE LARALEKWGH VTPV
Length:444
Mass (Da):50,281
Last modified:October 19, 2011 - v1
Checksum:i7636B3F260130FC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002920 Genomic DNA. Translation: AEK73792.1.
RefSeqiWP_014013474.1. NC_015865.1.
YP_004763469.1. NC_015865.1.

Genome annotation databases

EnsemblBacteriaiAEK73792; AEK73792; GQS_09490.
GeneIDi11016580.
KEGGithe:GQS_09490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002920 Genomic DNA. Translation: AEK73792.1 .
RefSeqi WP_014013474.1. NC_015865.1.
YP_004763469.1. NC_015865.1.

3D structure databases

ProteinModelPortali G0HNE1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEK73792 ; AEK73792 ; GQS_09490 .
GeneIDi 11016580.
KEGGi the:GQS_09490.

Phylogenomic databases

KOi K01601.
OMAi FTQDWAS.

Enzyme and pathway databases

BioCyci TSP1042877:GHEX-1932-MONOMER.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPi MF_01133. RuBisCO_L_type3.
InterProi IPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Thermococcus sp. strain 4557, a hyperthermophilic archaeon isolated from a deep-sea hydrothermal vent area."
    Wang X., Gao Z., Xu X., Ruan L.
    J. Bacteriol. 193:5544-5545(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CGMCC 1.5172 / 4557Imported.

Entry informationi

Entry nameiG0HNE1_THES4
AccessioniPrimary (citable) accession number: G0HNE1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: November 26, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.UniRule annotation

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3