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G0HLK1 (G0HLK1_THES4) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase RuleBase RU000617 HAMAP-Rule MF_00407

EC=6.5.1.1 RuleBase RU000617 HAMAP-Rule MF_00407
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] HAMAP-Rule MF_00407
Gene names
Name:lig HAMAP-Rule MF_00407
Ordered Locus Names:GQS_07890 EMBL AEK73474.1
OrganismThermococcus sp. (strain CGMCC 1.5172 / 4557) [Complete proteome] [HAMAP] EMBL AEK73474.1
Taxonomic identifier1042877 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus

Protein attributes

Sequence length559 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). RuleBase RU000617 HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. HAMAP-Rule MF_00407

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2491N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2471ATP By similarity HAMAP-Rule MF_00407
Binding site2541ATP By similarity HAMAP-Rule MF_00407
Binding site2691ATP By similarity HAMAP-Rule MF_00407
Binding site2991ATP By similarity HAMAP-Rule MF_00407
Binding site3391ATP By similarity HAMAP-Rule MF_00407
Binding site4141ATP By similarity HAMAP-Rule MF_00407
Binding site4201ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
G0HLK1 [UniParc].

Last modified October 19, 2011. Version 1.
Checksum: D415CBE4FF3B6BA9

FASTA55963,338
        10         20         30         40         50         60 
MKYAELADLY RRLEKTTLKT LKTKFVSDFL KKAPDELLDI IPYLILGKVF PDWDERELGV 

        70         80         90        100        110        120 
GEKLLIKAVS MATGVPEREI ENSVRDTGDL GESVALALKK KKQKSFFSQP LTIKRVYDTF 

       130        140        150        160        170        180 
MKIAEASGQG SQDRKLKYLA NLFMDAQPEE GKYLARTVLG TMRTGVAEGL MRDAIASAFG 

       190        200        210        220        230        240 
VKAELVERAY MLTSDFGYVA RVAKLEGNEG LSKVRIQVGK PIRPMLAQNA ANVKEALVEM 

       250        260        270        280        290        300 
GGKAAFEVKY DGARVQVHKD GDRVVIYSRR LENVTRSIPE VVDAVLESVK PEKAIVEGEL 

       310        320        330        340        350        360 
VAVGEGGKPR PFQYVLRRFR RKYNIEEMVE KIPLELNLFD VLYVDGDGMI DTPFSERRKK 

       370        380        390        400        410        420 
LEEIISQNER IRLAEQLVTT SADEAEEFYQ RALELGHEGL MAKRLDSVYE PGNRGKKWLK 

       430        440        450        460        470        480 
IKPTMEDLDL VIIGAEWGEG RRAHLLGSFL VAAFDPHSGE FVPVGKVGSG FTDEDLAEFT 

       490        500        510        520        530        540 
RMLKPLIVRE EGKYVEIEPK VVIQVTYQEI QKSPKYESGF ALRFPRYVAL REDKSPEEAD 

       550 
TIERIAQLYE FQERFKAKR 

« Hide

References

[1]"Complete Genome Sequence of Thermococcus sp. Strain 4557, a Hyperthermophilic Archaeon Isolated from a Deep-Sea Hydrothermal Vent Area."
Wang X., Gao Z., Xu X., Ruan L.
J. Bacteriol. 193:5544-5545(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CGMCC 1.5172 / 4557.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002920 Genomic DNA. Translation: AEK73474.1.
RefSeqYP_004763151.1. NC_015865.1.

3D structure databases

ProteinModelPortalG0HLK1.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEK73474; AEK73474; GQS_07890.
GeneID11016253.
KEGGthe:GQS_07890.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK10747.
OMAGRPRPFQ.

Enzyme and pathway databases

BioCycTSP1042877:GHEX-1604-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG0HLK1_THES4
AccessionPrimary (citable) accession number: G0HLK1
Entry history
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: February 19, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)