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Protein

DNA ligase

Gene

lig

Organism
Thermococcus sp. (strain CGMCC 1.5172 / 4557)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation
NAD+ + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + beta-nicotinamide D-nucleotide.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei247ATPUniRule annotation1
Active sitei249N6-AMP-lysine intermediateUniRule annotation1
Binding sitei254ATPUniRule annotation1
Binding sitei269ATPUniRule annotation1
Binding sitei299ATPUniRule annotation1
Binding sitei339ATPUniRule annotation1
Binding sitei414ATPUniRule annotation1
Binding sitei420ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, NADUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTSP1042877:G1GZH-1582-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.6UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP/NAD(+)]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:GQS_07890Imported
OrganismiThermococcus sp. (strain CGMCC 1.5172 / 4557)Imported
Taxonomic identifieri1042877 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000000874 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi1042877.GQS_07890

Structurei

3D structure databases

ProteinModelPortaliG0HLK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini327 – 455DNA_LIGASE_A3InterPro annotationAdd BLAST129

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
KOiK10747
OMAiWLFEESY
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

G0HLK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYAELADLY RRLEKTTLKT LKTKFVSDFL KKAPDELLDI IPYLILGKVF
60 70 80 90 100
PDWDERELGV GEKLLIKAVS MATGVPEREI ENSVRDTGDL GESVALALKK
110 120 130 140 150
KKQKSFFSQP LTIKRVYDTF MKIAEASGQG SQDRKLKYLA NLFMDAQPEE
160 170 180 190 200
GKYLARTVLG TMRTGVAEGL MRDAIASAFG VKAELVERAY MLTSDFGYVA
210 220 230 240 250
RVAKLEGNEG LSKVRIQVGK PIRPMLAQNA ANVKEALVEM GGKAAFEVKY
260 270 280 290 300
DGARVQVHKD GDRVVIYSRR LENVTRSIPE VVDAVLESVK PEKAIVEGEL
310 320 330 340 350
VAVGEGGKPR PFQYVLRRFR RKYNIEEMVE KIPLELNLFD VLYVDGDGMI
360 370 380 390 400
DTPFSERRKK LEEIISQNER IRLAEQLVTT SADEAEEFYQ RALELGHEGL
410 420 430 440 450
MAKRLDSVYE PGNRGKKWLK IKPTMEDLDL VIIGAEWGEG RRAHLLGSFL
460 470 480 490 500
VAAFDPHSGE FVPVGKVGSG FTDEDLAEFT RMLKPLIVRE EGKYVEIEPK
510 520 530 540 550
VVIQVTYQEI QKSPKYESGF ALRFPRYVAL REDKSPEEAD TIERIAQLYE

FQERFKAKR
Length:559
Mass (Da):63,338
Last modified:October 19, 2011 - v1
Checksum:iD415CBE4FF3B6BA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002920 Genomic DNA Translation: AEK73474.1
RefSeqiWP_014013156.1, NC_015865.1

Genome annotation databases

EnsemblBacteriaiAEK73474; AEK73474; GQS_07890
GeneIDi11016253
KEGGithe:GQS_07890
PATRICifig|1042877.9.peg.1532

Similar proteinsi

Entry informationi

Entry nameiG0HLK1_THES4
AccessioniPrimary (citable) accession number: G0HLK1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: April 25, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health