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G0HLK1

- G0HLK1_THES4

UniProt

G0HLK1 - G0HLK1_THES4

Protein

DNA ligase

Gene

lig

Organism
Thermococcus sp. (strain CGMCC 1.5172 / 4557)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei247 – 2471ATPUniRule annotation
    Active sitei249 – 2491N6-AMP-lysine intermediateUniRule annotation
    Binding sitei254 – 2541ATPUniRule annotation
    Binding sitei269 – 2691ATPUniRule annotation
    Binding sitei299 – 2991ATPUniRule annotation
    Binding sitei339 – 3391ATPUniRule annotation
    Binding sitei414 – 4141ATPUniRule annotation
    Binding sitei420 – 4201ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTSP1042877:GHEX-1604-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:GQS_07890Imported
    OrganismiThermococcus sp. (strain CGMCC 1.5172 / 4557)Imported
    Taxonomic identifieri1042877 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
    ProteomesiUP000000874: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliG0HLK1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10747.
    OMAiARVQVHK.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G0HLK1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKYAELADLY RRLEKTTLKT LKTKFVSDFL KKAPDELLDI IPYLILGKVF    50
    PDWDERELGV GEKLLIKAVS MATGVPEREI ENSVRDTGDL GESVALALKK 100
    KKQKSFFSQP LTIKRVYDTF MKIAEASGQG SQDRKLKYLA NLFMDAQPEE 150
    GKYLARTVLG TMRTGVAEGL MRDAIASAFG VKAELVERAY MLTSDFGYVA 200
    RVAKLEGNEG LSKVRIQVGK PIRPMLAQNA ANVKEALVEM GGKAAFEVKY 250
    DGARVQVHKD GDRVVIYSRR LENVTRSIPE VVDAVLESVK PEKAIVEGEL 300
    VAVGEGGKPR PFQYVLRRFR RKYNIEEMVE KIPLELNLFD VLYVDGDGMI 350
    DTPFSERRKK LEEIISQNER IRLAEQLVTT SADEAEEFYQ RALELGHEGL 400
    MAKRLDSVYE PGNRGKKWLK IKPTMEDLDL VIIGAEWGEG RRAHLLGSFL 450
    VAAFDPHSGE FVPVGKVGSG FTDEDLAEFT RMLKPLIVRE EGKYVEIEPK 500
    VVIQVTYQEI QKSPKYESGF ALRFPRYVAL REDKSPEEAD TIERIAQLYE 550
    FQERFKAKR 559
    Length:559
    Mass (Da):63,338
    Last modified:October 19, 2011 - v1
    Checksum:iD415CBE4FF3B6BA9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002920 Genomic DNA. Translation: AEK73474.1.
    RefSeqiWP_014013156.1. NC_015865.1.
    YP_004763151.1. NC_015865.1.

    Genome annotation databases

    EnsemblBacteriaiAEK73474; AEK73474; GQS_07890.
    GeneIDi11016253.
    KEGGithe:GQS_07890.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002920 Genomic DNA. Translation: AEK73474.1 .
    RefSeqi WP_014013156.1. NC_015865.1.
    YP_004763151.1. NC_015865.1.

    3D structure databases

    ProteinModelPortali G0HLK1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEK73474 ; AEK73474 ; GQS_07890 .
    GeneIDi 11016253.
    KEGGi the:GQS_07890.

    Phylogenomic databases

    KOi K10747.
    OMAi ARVQVHK.

    Enzyme and pathway databases

    BioCyci TSP1042877:GHEX-1604-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Thermococcus sp. strain 4557, a hyperthermophilic archaeon isolated from a deep-sea hydrothermal vent area."
      Wang X., Gao Z., Xu X., Ruan L.
      J. Bacteriol. 193:5544-5545(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CGMCC 1.5172 / 4557Imported.

    Entry informationi

    Entry nameiG0HLK1_THES4
    AccessioniPrimary (citable) accession number: G0HLK1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 19, 2011
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3