ID   G0HKN5_THES4            Unreviewed;       457 AA.
AC   G0HKN5;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   SubName: Full=Cytoplasmic alpha-amylase {ECO:0000313|EMBL:AEK73316.1};
DE            EC=3.2.1.1 {ECO:0000313|EMBL:AEK73316.1};
GN   OrderedLocusNames=GQS_07090 {ECO:0000313|EMBL:AEK73316.1};
OS   Thermococcus sp. (strain CGMCC 1.5172 / 4557).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=1042877 {ECO:0000313|EMBL:AEK73316.1, ECO:0000313|Proteomes:UP000000874};
RN   [1] {ECO:0000313|EMBL:AEK73316.1, ECO:0000313|Proteomes:UP000000874}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.5172 / 4557 {ECO:0000313|Proteomes:UP000000874};
RX   PubMed=21914870; DOI=10.1128/JB.05851-11;
RA   Wang X., Gao Z., Xu X., Ruan L.;
RT   "Complete genome sequence of Thermococcus sp. strain 4557, a
RT   hyperthermophilic archaeon isolated from a deep-sea hydrothermal vent
RT   area.";
RL   J. Bacteriol. 193:5544-5545(2011).
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 13 family.
CC       {ECO:0000256|ARBA:ARBA00008061}.
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DR   EMBL; CP002920; AEK73316.1; -; Genomic_DNA.
DR   RefSeq; WP_014012998.1; NC_015865.1.
DR   AlphaFoldDB; G0HKN5; -.
DR   STRING; 1042877.GQS_07090; -.
DR   GeneID; 11016092; -.
DR   KEGG; the:GQS_07090; -.
DR   PATRIC; fig|1042877.9.peg.1382; -.
DR   eggNOG; arCOG02954; Archaea.
DR   HOGENOM; CLU_024572_3_0_2; -.
DR   OrthoDB; 18347at2157; -.
DR   Proteomes; UP000000874; Chromosome.
DR   GO; GO:0004556; F:alpha-amylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd11314; AmyAc_arch_bac_plant_AmyA; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   InterPro; IPR013776; A-amylase_thermo.
DR   InterPro; IPR015237; Alpha-amylase_C_pro.
DR   InterPro; IPR006046; Alpha_amylase.
DR   InterPro; IPR006047; Glyco_hydro_13_cat_dom.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR43447; ALPHA-AMYLASE; 1.
DR   PANTHER; PTHR43447:SF49; ALPHA-AMYLASE; 1.
DR   Pfam; PF09154; Alpha-amy_C_pro; 1.
DR   Pfam; PF00128; Alpha-amylase; 1.
DR   PIRSF; PIRSF001021; Alph-amls_thrmst; 1.
DR   PRINTS; PR00110; ALPHAAMYLASE.
DR   SMART; SM00642; Aamy; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000313|EMBL:AEK73316.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:AEK73316.1}.
FT   DOMAIN          32..377
FT                   /note="Glycosyl hydrolase family 13 catalytic"
FT                   /evidence="ECO:0000259|SMART:SM00642"
SQ   SEQUENCE   457 AA;  51766 MW;  2DE4782BE121CD29 CRC64;
     MARKVLVALL VLLVFLSVSA VPAKAETLEN GGVIMQAFYW DVPGGGIWWD TIAQKIPDWA
     SAGISAIWIP PASKGMSGGY SMGYDPYDYF DLGEYYQKGT VETRFGSKQE LVNMINTAHA
     YGIKVIADIV INHRAGGDLE WNPFVGDYTW TDFSKVASGK YTANYLDFHP NEVKCCDEGT
     FGGYPDIAHE KSWDQYWLWA SQESYAAYLR SIGIDAWRFD YVKGYGAWVV KDWLNWWGGW
     AVGEYWDTNV DALLNWAYNS NAKVFDFPLY YKMDEAFDNN NIPALVDALK NGGTVVSRDP
     FKAVTFVANH DTDIIWNKYP AYAFILTYEG QPTIFYRDYE EWLNKDRLNN LIWIHDHLAG
     GSTDIVYYDN DELIFVRNGY GDKPGLITYI NLGSSKAGRW VYVPKFAGSC IHEYTGNLGG
     WVDKWVYSSG WVYLEAPAHD PANGQYGYSV WSYCGVG
//