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G0HBI5 (G0HBI5_CORVD) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047
EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddlA EMBL AEK37098.1
Synonyms:ddl HAMAP-Rule MF_00047
Ordered Locus Names:CVAR_1746 EMBL AEK37098.1
OrganismCorynebacterium variabile (strain DSM 44702 / JCM 12073 / NCIMB 30131) (Corynebacterium mooreparkense) [Complete proteome] [HAMAP]
Taxonomic identifier858619 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium ›

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047 SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain155 – 359205ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding182 – 23756ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3141Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3261Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3261Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3281Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
G0HBI5 [UniParc].

Last modified October 19, 2011. Version 1.
Checksum: 0A307171DE46CF8B

FASTA36539,188
        10         20         30         40         50         60 
MSNTEPTSPA ARTVVAVLYG GQNSEHSISC LSAAAVMSHL DPDRYEVVPV GITETGMWVK 

        70         80         90        100        110        120 
GTTDTEALSA HGRDLPTVKM SRGVHLVPGS FASGRGQLRY GDGSLYAEVD VIFPVLHGRN 

       130        140        150        160        170        180 
GEDGTVQGVL ELSNVPYVGN GVLASAACMD KQYTKLIARA AGVPVGDEVV LTERRDLTDE 

       190        200        210        220        230        240 
EKEMIGLPVF VKPARGGSSV GISKVSDWAD LDAAEAHAFE HDTKILVEAM LHGVEVECGV 

       250        260        270        280        290        300 
LQYPDGTVHA SQPSLLEGTE DGPEGFYGFD TKYLDDIISY EIPAPLPEGQ ADAVRRWAVE 

       310        320        330        340        350        360 
TFRALDCEGL ARVDFFVTED GPVLNEPNTM PGFTPISMYP KMFEATGVAY TELLDILIAR 


ALVRK

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References

[1]"Complete genome sequence of Corynebacterium variabile DSM 44702 isolated from the surface of smear-ripened cheeses and insights into cheese ripening and flavor generation."
Schroeder J., Maus I., Trost E., Tauch A.
BMC Genomics 12:545-545(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 44702 / JCM 12073 / NCIMB 30131.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002917 Genomic DNA. Translation: AEK37098.1.
RefSeqYP_004760171.1. NC_015859.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEK37098; AEK37098; CVAR_1746.
GeneID11000529.
KEGGcva:CVAR_1746.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycCVAR858619:GHOU-1795-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG0HBI5_CORVD
AccessionPrimary (citable) accession number: G0HBI5
Entry history
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: April 3, 2013
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info