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G0H495 (G0H495_METMI) Unreviewed, UniProtKB/TrEMBL

Last modified March 6, 2013. Version 9. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Malate dehydrogenase HAMAP-Rule MF_00487
EC=1.1.1.37 HAMAP-Rule MF_00487
Gene names
Name:mdh HAMAP-Rule MF_00487
ORF Names:GYY_03235 EMBL AEK19526.1
OrganismMethanococcus maripaludis (Methanococcus deltae)
Taxonomic identifier39152 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_00487

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP-Rule MF_00487

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 3 family. HAMAP-Rule MF_00487

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding7 – 137NAD By similarity HAMAP-Rule MF_00487
Nucleotide binding121 – 1233NAD By similarity HAMAP-Rule MF_00487

Sites

Active site1781Proton acceptor By similarity HAMAP-Rule MF_00487
Binding site861Substrate By similarity HAMAP-Rule MF_00487
Binding site921Substrate By similarity HAMAP-Rule MF_00487
Binding site991NAD By similarity HAMAP-Rule MF_00487
Binding site1231Substrate By similarity HAMAP-Rule MF_00487
Binding site1541Substrate By similarity HAMAP-Rule MF_00487

Sequences

Sequence LengthMass (Da)Tools
G0H495 [UniParc].

Last modified October 19, 2011. Version 1.
Checksum: 4C3E363B5AEB6784

FASTA31434,494
        10         20         30         40         50         60 
MDVSIIGASG KIGSVLSLLL AKESYIKNIN LIARSSSINK LKGLKMDLYD AMAAAGQDTD 

        70         80         90        100        110        120 
IDICCDDDLS CTANSDITII TAGMARTGEM SRIDLMKGNA KIVKNYVKNI ANFGDTKIFM 

       130        140        150        160        170        180 
ISNPVDLMTY KALIESGYEK NQVFGLGTHL DSMRFKVAVA KHFEVHLDDV RTRIVGEHGD 

       190        200        210        220        230        240 
SMVPVISATA VGGIPIKRLP KYEDFPYEKI LERIKGYGQE IINLKNGSEY GPASAIVNIV 

       250        260        270        280        290        300 
RCIAHDEKRL LTLSTYIEDE IEGIEGGCCI GVPVKVGKNG IEEVIHIKME DDEIEGFKKS 

       310 
FELVKGYCRQ IESI

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References

[1]"Complete Genome Sequence of a Nonculturable Methanococcus maripaludis Strain Extracted in a Metagenomic Survey of Petroleum Reservoir Fluids."
Wang X., Greenfield P., Li D., Hendry P., Volk H., Sutherland T.D.
J. Bacteriol. 193:5595-5595(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: X1 EMBL AEK19526.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002913 Genomic DNA. Translation: AEK19526.1.
RefSeqYP_004742269.1. NC_015847.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID10982073.
KEGGmmd:GYY_03235.

Phylogenomic databases

KOK00024.
OMADAMTYVM.

Enzyme and pathway databases

BioCycMMAR1053692:GH1C-656-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_00487. Malate_dehydrog_3.
InterProIPR001557. L-lactate/malate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
PROSITEPS00064. L_LDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG0H495_METMI
AccessionPrimary (citable) accession number: G0H495
Entry history
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: March 6, 2013
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info