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G0H495

- G0H495_METMI

UniProt

G0H495 - G0H495_METMI

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Protein
Malate dehydrogenase
Gene
mdh, GYY_03235
Organism
Methanococcus maripaludis X1
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei86 – 861Substrate By similarityUniRule annotation
Binding sitei92 – 921Substrate By similarityUniRule annotation
Binding sitei99 – 991NAD By similarityUniRule annotation
Binding sitei123 – 1231Substrate By similarityUniRule annotation
Binding sitei154 – 1541Substrate By similarityUniRule annotation
Active sitei178 – 1781Proton acceptor By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 137NAD By similarityUniRule annotation
Nucleotide bindingi121 – 1233NAD By similarityUniRule annotation

GO - Molecular functioni

  1. L-lactate dehydrogenase activity Source: InterPro
  2. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

NADUniRule annotation

Enzyme and pathway databases

BioCyciMMAR1053692:GH1C-658-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
ORF Names:GYY_03235Imported
OrganismiMethanococcus maripaludis X1Imported
Taxonomic identifieri1053692 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000008889: Chromosome

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00024.
OMAiYGVAMML.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
PROSITEiPS00064. L_LDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G0H495-1 [UniParc]FASTAAdd to Basket

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MDVSIIGASG KIGSVLSLLL AKESYIKNIN LIARSSSINK LKGLKMDLYD    50
AMAAAGQDTD IDICCDDDLS CTANSDITII TAGMARTGEM SRIDLMKGNA 100
KIVKNYVKNI ANFGDTKIFM ISNPVDLMTY KALIESGYEK NQVFGLGTHL 150
DSMRFKVAVA KHFEVHLDDV RTRIVGEHGD SMVPVISATA VGGIPIKRLP 200
KYEDFPYEKI LERIKGYGQE IINLKNGSEY GPASAIVNIV RCIAHDEKRL 250
LTLSTYIEDE IEGIEGGCCI GVPVKVGKNG IEEVIHIKME DDEIEGFKKS 300
FELVKGYCRQ IESI 314
Length:314
Mass (Da):34,494
Last modified:October 19, 2011 - v1
Checksum:i4C3E363B5AEB6784
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002913 Genomic DNA. Translation: AEK19526.1.
RefSeqiYP_004742269.1. NC_015847.1.

Genome annotation databases

GeneIDi10982073.
KEGGimmd:GYY_03235.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002913 Genomic DNA. Translation: AEK19526.1 .
RefSeqi YP_004742269.1. NC_015847.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 10982073.
KEGGi mmd:GYY_03235.

Phylogenomic databases

KOi K00024.
OMAi YGVAMML.

Enzyme and pathway databases

BioCyci MMAR1053692:GH1C-658-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
PROSITEi PS00064. L_LDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete Genome Sequence of a Nonculturable Methanococcus maripaludis Strain Extracted in a Metagenomic Survey of Petroleum Reservoir Fluids."
    Wang X., Greenfield P., Li D., Hendry P., Volk H., Sutherland T.D.
    J. Bacteriol. 193:5595-5595(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: X1Imported.

Entry informationi

Entry nameiG0H495_METMI
AccessioniPrimary (citable) accession number: G0H495
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: June 11, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi