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G0H495

- G0H495_METMI

UniProt

G0H495 - G0H495_METMI

Protein

Malate dehydrogenase

Gene

mdh

Organism
Methanococcus maripaludis X1
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei86 – 861SubstrateUniRule annotation
    Binding sitei92 – 921SubstrateUniRule annotation
    Binding sitei99 – 991NADUniRule annotation
    Binding sitei123 – 1231SubstrateUniRule annotation
    Binding sitei154 – 1541SubstrateUniRule annotation
    Active sitei178 – 1781Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 137NADUniRule annotation
    Nucleotide bindingi121 – 1233NADUniRule annotation

    GO - Molecular functioni

    1. L-lactate dehydrogenase activity Source: InterPro
    2. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    NADUniRule annotation

    Enzyme and pathway databases

    BioCyciMMAR1053692:GH1C-658-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    ORF Names:GYY_03235Imported
    OrganismiMethanococcus maripaludis X1Imported
    Taxonomic identifieri1053692 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
    ProteomesiUP000008889: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    KOiK00024.
    OMAiYGVAMML.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR018177. L-lactate_DH_AS.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    PROSITEiPS00064. L_LDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G0H495-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVSIIGASG KIGSVLSLLL AKESYIKNIN LIARSSSINK LKGLKMDLYD    50
    AMAAAGQDTD IDICCDDDLS CTANSDITII TAGMARTGEM SRIDLMKGNA 100
    KIVKNYVKNI ANFGDTKIFM ISNPVDLMTY KALIESGYEK NQVFGLGTHL 150
    DSMRFKVAVA KHFEVHLDDV RTRIVGEHGD SMVPVISATA VGGIPIKRLP 200
    KYEDFPYEKI LERIKGYGQE IINLKNGSEY GPASAIVNIV RCIAHDEKRL 250
    LTLSTYIEDE IEGIEGGCCI GVPVKVGKNG IEEVIHIKME DDEIEGFKKS 300
    FELVKGYCRQ IESI 314
    Length:314
    Mass (Da):34,494
    Last modified:October 19, 2011 - v1
    Checksum:i4C3E363B5AEB6784
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002913 Genomic DNA. Translation: AEK19526.1.
    RefSeqiYP_004742269.1. NC_015847.1.

    Genome annotation databases

    GeneIDi10982073.
    KEGGimmd:GYY_03235.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002913 Genomic DNA. Translation: AEK19526.1 .
    RefSeqi YP_004742269.1. NC_015847.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 10982073.
    KEGGi mmd:GYY_03235.

    Phylogenomic databases

    KOi K00024.
    OMAi YGVAMML.

    Enzyme and pathway databases

    BioCyci MMAR1053692:GH1C-658-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR018177. L-lactate_DH_AS.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    PROSITEi PS00064. L_LDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete Genome Sequence of a Nonculturable Methanococcus maripaludis Strain Extracted in a Metagenomic Survey of Petroleum Reservoir Fluids."
      Wang X., Greenfield P., Li D., Hendry P., Volk H., Sutherland T.D.
      J. Bacteriol. 193:5595-5595(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: X1Imported.

    Entry informationi

    Entry nameiG0H495_METMI
    AccessioniPrimary (citable) accession number: G0H495
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 19, 2011
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3