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Protein

Tyrosine recombinase XerC

Gene

xerC

Organism
Rickettsia heilongjiangensis (strain ATCC VR-1524 / 054)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei159 – 1591UniRule annotation
Active sitei182 – 1821UniRule annotation
Active sitei250 – 2501UniRule annotation
Active sitei253 – 2531UniRule annotation
Active sitei276 – 2761UniRule annotation
Active sitei285 – 2851O-(3'-phospho-DNA)-tyrosine intermediateUniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. tyrosine-based site-specific recombinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. chromosome segregation Source: UniProtKB-HAMAP
  4. transposition, DNA-mediated Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, Chromosome partitionUniRule annotation, DNA integrationUniRule annotationSAAS annotation, DNA recombinationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciRHEI1032845:GI4V-1231-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine recombinase XerCUniRule annotation
Gene namesi
Name:xerCUniRule annotationImported
Ordered Locus Names:Rh054_06895Imported
OrganismiRickettsia heilongjiangensis (strain ATCC VR-1524 / 054)Imported
Taxonomic identifieri1032845 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000865: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the 'phage' integrase family. XerC subfamily.UniRule annotation

Phylogenomic databases

KOiK03733.

Family and domain databases

Gene3Di1.10.150.130. 1 hit.
1.10.443.10. 1 hit.
HAMAPiMF_01808. Recomb_XerC.
InterProiIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat-core.
IPR002104. Integrase_catalytic.
IPR023109. Integrase_recombinase_N.
IPR004107. Integrase_SAM-like_N.
IPR023009. Tyrosine_recombinase_XerC/XerD.
[Graphical view]
PfamiPF02899. Phage_int_SAM_1. 1 hit.
PF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 1 hit.

Sequencei

Sequence statusi: Complete.

G0GW23-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLDTSIQALI NKWQKYLVLQ RNYSNHTAIS YNNDLKHFLE FMNYYNSELV
60 70 80 90 100
TINHIKTADI RLIRSWLAKR NCDNFTASSI SRGLSAVKNF YRFLEKTTQL
110 120 130 140 150
NSHIIFSIKS PKKTKLLPKA LSEDDVVISL EHIEEYGNVK WVELRNKALL
160 170 180 190 200
VLIYASGLRI SEALSITKLH LQNLEFIRII GKGSKERIIP WLPIAKNLIT
210 220 230 240 250
QYLEILPYKL GDNEPIFRGK QGKKLQPPVF NRELIKLKHF YGLPQHLTAH
260 270 280 290 300
SFRHSFASHL LEHGADLRSL QELLGHKSLS TTQNYTKTSI KHLEAVYTTA

YPIKK
Length:305
Mass (Da):35,353
Last modified:October 19, 2011 - v1
Checksum:i945F4F61D5880823
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002912 Genomic DNA. Translation: AEK75228.1.
RefSeqiYP_004764906.1. NC_015866.1.

Genome annotation databases

EnsemblBacteriaiAEK75228; AEK75228; Rh054_06895.
GeneIDi11014539.
KEGGirhe:Rh054_06895.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002912 Genomic DNA. Translation: AEK75228.1.
RefSeqiYP_004764906.1. NC_015866.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEK75228; AEK75228; Rh054_06895.
GeneIDi11014539.
KEGGirhe:Rh054_06895.

Phylogenomic databases

KOiK03733.

Enzyme and pathway databases

BioCyciRHEI1032845:GI4V-1231-MONOMER.

Family and domain databases

Gene3Di1.10.150.130. 1 hit.
1.10.443.10. 1 hit.
HAMAPiMF_01808. Recomb_XerC.
InterProiIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat-core.
IPR002104. Integrase_catalytic.
IPR023109. Integrase_recombinase_N.
IPR004107. Integrase_SAM-like_N.
IPR023009. Tyrosine_recombinase_XerC/XerD.
[Graphical view]
PfamiPF02899. Phage_int_SAM_1. 1 hit.
PF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Rickettsia heilongjiangensis, an emerging tick-transmitted human pathogen."
    Duan C., Tong Y., Huang Y., Wang X., Xiong X., Wen B.
    J. Bacteriol. 193:5564-5565(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1524 / 054Imported.

Entry informationi

Entry nameiG0GW23_RICH0
AccessioniPrimary (citable) accession number: G0GW23
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: February 4, 2015
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.