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Protein

Isocitrate dehydrogenase [NADP]

Gene

Spith_1886

Organism
Spirochaeta thermophila (strain ATCC 700085 / DSM 6578 / Z-1203)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciSTHE869211:GLKE-1927-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Spith_1886Imported
OrganismiSpirochaeta thermophila (strain ATCC 700085 / DSM 6578 / Z-1203)Imported
Taxonomic identifieri869211 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeSpirochaeta
ProteomesiUP000007254 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliG0GD69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.
OMAiFRDWGYE.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G0GD69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEKIRKEAG GLVVPDEPVI PFIQGDGTGP DIWRAAVRVF DAAVEKAYGG
60 70 80 90 100
RRKVAWLEVF AGERAYREKG TWLPDETLEA FKEYLVGIKG PLTTPVGGGF
110 120 130 140 150
RSLNVTLRQM LDLYVCLRPV KYYPGIPSPV RHPELVDMVV FRENTEDVYA
160 170 180 190 200
GFELPSGDER TKRLIEFCRR EFGWQIREDS GIGVKPISPT GTKRLVRAAI
210 220 230 240 250
RYALDHGRRS VTLVHKGNIM KYTEGAFRAW GYEVAKEEFG DRVVTWEDVP
260 270 280 290 300
DGVVPEGKVL VKDAIADAFL QQILTRPAEF DVIATMNLNG DYVSDALAAQ
310 320 330 340 350
VGGIGIAPGA NINYDTGHAI FEATHGTAPK YAGKDMVNPS SVILSGKMMF
360 370 380 390 400
EYLGWHEAAA LIEKGLTGAI ASRKVTYDFA RLMEGAEQVS TSEFGNQIVA

HM
Length:402
Mass (Da):44,319
Last modified:October 19, 2011 - v1
Checksum:iDADB099D03432422
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002903 Genomic DNA. Translation: AEJ62144.1.
RefSeqiWP_014625469.1. NC_017583.1.
YP_006045861.1. NC_017583.1.

Genome annotation databases

EnsemblBacteriaiAEJ62144; AEJ62144; Spith_1886.
KEGGistq:Spith_1886.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002903 Genomic DNA. Translation: AEJ62144.1.
RefSeqiWP_014625469.1. NC_017583.1.
YP_006045861.1. NC_017583.1.

3D structure databases

ProteinModelPortaliG0GD69.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEJ62144; AEJ62144; Spith_1886.
KEGGistq:Spith_1886.

Phylogenomic databases

KOiK00031.
OMAiFRDWGYE.

Enzyme and pathway databases

BioCyciSTHE869211:GLKE-1927-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700085 / DSM 6578 / Z-1203Imported.

Entry informationi

Entry nameiG0GD69_SPITZ
AccessioniPrimary (citable) accession number: G0GD69
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: May 27, 2015
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.