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Protein

Glutamate decarboxylase

Gene

gadB

Organism
Amycolatopsis mediterranei (strain S699) (Nocardia mediterranei)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Name:gadBImported
Ordered Locus Names:AMES_8734Imported, RAM_45505Imported
OrganismiAmycolatopsis mediterranei (strain S699) (Nocardia mediterranei)Imported
Taxonomic identifieri713604 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeAmycolatopsis
ProteomesiUP000006138 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliG0FKM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

KOiK01580.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

G0FKM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLHQGKAGR PDRTAGTNPL YAGANPALAA GFVMPHDKLR EDSLPPDTAL
60 70 80 90 100
QLVRDELMLD GNARLNLATF VTTWMEPQAR ELMAECVDKN MIDKDEYPQT
110 120 130 140 150
AELERRCVNI LADLWHAPDP GDVMGCSTTG SSEACMLAGM ALKRRWSKLG
160 170 180 190 200
RTGKPNLVMG ANVQVCWEKF CEYWEVEPRL VPMDGDRYHL TADEAVARCD
210 220 230 240 250
ENTIGVVAIL GSTFDGSYEP VAEIAAALDS LEERTGWDIP VHVDGASGAM
260 270 280 290 300
IAPFLDPHLE WDFRLPRVAS INTSGHKYGL VYPGVGWVLW RDKAALPSEL
310 320 330 340 350
VFNVNYLGGD MPTFALNFSR PGAEVAAQYY TFVRLGREGF RAVQQASRDV
360 370 380 390 400
ALHLSSGIAS LGPFSLLTRG DQLPVFAFTT RPDVGFDVFD VSRRLRERGW
410 420 430 440 450
LVPAYTFPEN RTDLAVLRIV VRNGFTHDLA DLLLADLRRV LPELEQFGGR
460
PKDPAKATAF HH
Length:462
Mass (Da):51,110
Last modified:October 18, 2011 - v1
Checksum:iD2D44AF965447041
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002896 Genomic DNA. Translation: AEK47566.1.
CP003729 Genomic DNA. Translation: AFO82266.1.
RefSeqiYP_005537023.1. NC_017186.1.
YP_006555211.1. NC_018266.1.

Genome annotation databases

EnsemblBacteriaiAEK47566; AEK47566; RAM_45505.
AFO82266; AFO82266; AMES_8734.
KEGGiamm:AMES_8734.
amn:RAM_45505.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002896 Genomic DNA. Translation: AEK47566.1.
CP003729 Genomic DNA. Translation: AFO82266.1.
RefSeqiYP_005537023.1. NC_017186.1.
YP_006555211.1. NC_018266.1.

3D structure databases

ProteinModelPortaliG0FKM5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEK47566; AEK47566; RAM_45505.
AFO82266; AFO82266; AMES_8734.
KEGGiamm:AMES_8734.
amn:RAM_45505.

Phylogenomic databases

KOiK01580.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Whole genome sequence of the rifamycin B-producing strain Amycolatopsis mediterranei S699."
    Verma M., Kaur J., Kumar M., Kumari K., Saxena A., Anand S., Nigam A., Ravi V., Raghuvanshi S., Khurana P., Tyagi A.K., Khurana J.P., Lal R.
    J. Bacteriol. 193:5562-5563(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S699Imported.
  2. "Complete genome sequence of Amycolatopsis mediterranei S699 based on de novo assembly via a combinatorial sequencing strategy."
    Tang B., Zhao W., Zheng H., Zhuo Y., Zhang L., Zhao G.P.
    J. Bacteriol. 194:5699-5700(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S699Imported.
  3. Biao T.
    Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: S699Imported.

Entry informationi

Entry nameiG0FKM5_AMYMS
AccessioniPrimary (citable) accession number: G0FKM5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 18, 2011
Last sequence update: October 18, 2011
Last modified: March 31, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.