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G0F028

- G0F028_CUPNN

UniProt

G0F028 - G0F028_CUPNN

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Cupriavidus necator (strain ATCC 43291 / DSM 13513 / N-1) (Ralstonia eutropha)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotationSAAS annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCNEC1042878:GH0Z-3572-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotationImported
    Ordered Locus Names:CNE_1c35720Imported
    OrganismiCupriavidus necator (strain ATCC 43291 / DSM 13513 / N-1) (Ralstonia eutropha)Imported
    Taxonomic identifieri1042878 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
    ProteomesiUP000006798: Chromosome 1

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei722 – 7221N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    KOiK00281.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    G0F028-1 [UniParc]FASTAAdd to Basket

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    MNAPLPMNAA QVTRPTLAEL EARDAFAARH IGPDTPEQQH MLKVLGYDSR    50
    AALIDAVIPA AIRRRDGMPM GEFTEPLSEE AALAKLRGLA GRNKVLKSFI 100
    GQGYYNTVTP GVILRNIFEN PAWYTAYTPY QPEISQGRLE AMLNFQQMVT 150
    DLTGLDIANA SMLDEGTAAA EAMTLLQRVN KHDSNTFYVA DDVLPQTLEV 200
    VRTRALPMGI EVKVGPAAEA AAANAFGVLL QYPGVNGDVN DYGAIADAVH 250
    AAGGLVVAAA DLLALTLIAA PGEWGADVAV GNSQRFGVPL GFGGPHAGYM 300
    AVKDAFKRSM PGRLVGVTID AQGNKAYRLA LQTREQHIRR EKATSNICTA 350
    QVLLAVMASM YAVYHGPQGL KRIAQRVHRL TATLAAGLQA LGFARTNASF 400
    FDTLTLETGF NTDAIHAAAT ARGINLRHIS ATRVGISLDE TASRADVVAL 450
    WEVFTQGKPL PAELDFDKLE AVAQDAFPAA LARASEYLTH PVFNTHHAEH 500
    EMLRYLRMLA DKDLALDRTM IPLGSCTMKL NATSEMIPVT WPEFSQIHPF 550
    APLDQTVGYR EMIDQLEAML CAATGYAAVS LQPNAGSQGE YAGLLIIHAY 600
    HASRGESHRD ICLIPSSAHG TNPASAQMAG MKVVVVACDE DGNVDLQDLA 650
    KKAEQHSKNL AAIMITYPST HGVFEQGVQQ ICEIVHQHGG QVYVDGANMN 700
    AMVGTAAPGQ FGGDVSHLNL HKTFCIPHGG GGPGVGPVAV GAHLADFLPN 750
    QDSVGYRRDD RGIGGVSAAP FGSASILPIS WMYIAMMGSA GLTAATENAI 800
    LAANYVAKRL APYYPVLYTG QHDLVAHECI LDLRPLQKDT GISNEDVAKR 850
    LMDYGFHAPT MSFPVPGTLM IEPTESEALH ELDRFIDAMI AIRQEIGRVA 900
    DGTFDRDDNP LKHAPHTAAV VTADEWTHKY TREEAAYPVA SLRTQKYWPP 950
    VGRADNVYGD RNLFCACVPV SDYVVD 976
    Length:976
    Mass (Da):104,999
    Last modified:October 19, 2011 - v1
    Checksum:iA9A9D4EC2E7B7DC2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002877 Genomic DNA. Translation: AEI78864.1.
    RefSeqiYP_004687345.1. NC_015726.1.

    Genome annotation databases

    EnsemblBacteriaiAEI78864; AEI78864; CNE_1c35720.
    GeneIDi10919963.
    KEGGicnc:CNE_1c35720.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002877 Genomic DNA. Translation: AEI78864.1 .
    RefSeqi YP_004687345.1. NC_015726.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEI78864 ; AEI78864 ; CNE_1c35720 .
    GeneIDi 10919963.
    KEGGi cnc:CNE_1c35720.

    Phylogenomic databases

    KOi K00281.

    Enzyme and pathway databases

    BioCyci CNEC1042878:GH0Z-3572-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the type strain Cupriavidus necator N-1."
      Poehlein A., Kusian B., Friedrich B., Daniel R., Bowien B.
      J. Bacteriol. 193:5017-5017(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43291 / DSM 13513 / N-1Imported.

    Entry informationi

    Entry nameiG0F028_CUPNN
    AccessioniPrimary (citable) accession number: G0F028
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 19, 2011
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3