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G0F028

- G0F028_CUPNN

UniProt

G0F028 - G0F028_CUPNN

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, CNE_1c35720
Organism
Cupriavidus necator (strain ATCC 43291 / DSM 13513 / N-1) (Ralstonia eutropha)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciCNEC1042878:GH0Z-3572-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvPUniRule annotationImported
Ordered Locus Names:CNE_1c35720Imported
OrganismiCupriavidus necator (strain ATCC 43291 / DSM 13513 / N-1) (Ralstonia eutropha)Imported
Taxonomic identifieri1042878 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000006798: Chromosome 1

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei722 – 7221N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

KOiK00281.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

G0F028-1 [UniParc]FASTAAdd to Basket

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MNAPLPMNAA QVTRPTLAEL EARDAFAARH IGPDTPEQQH MLKVLGYDSR    50
AALIDAVIPA AIRRRDGMPM GEFTEPLSEE AALAKLRGLA GRNKVLKSFI 100
GQGYYNTVTP GVILRNIFEN PAWYTAYTPY QPEISQGRLE AMLNFQQMVT 150
DLTGLDIANA SMLDEGTAAA EAMTLLQRVN KHDSNTFYVA DDVLPQTLEV 200
VRTRALPMGI EVKVGPAAEA AAANAFGVLL QYPGVNGDVN DYGAIADAVH 250
AAGGLVVAAA DLLALTLIAA PGEWGADVAV GNSQRFGVPL GFGGPHAGYM 300
AVKDAFKRSM PGRLVGVTID AQGNKAYRLA LQTREQHIRR EKATSNICTA 350
QVLLAVMASM YAVYHGPQGL KRIAQRVHRL TATLAAGLQA LGFARTNASF 400
FDTLTLETGF NTDAIHAAAT ARGINLRHIS ATRVGISLDE TASRADVVAL 450
WEVFTQGKPL PAELDFDKLE AVAQDAFPAA LARASEYLTH PVFNTHHAEH 500
EMLRYLRMLA DKDLALDRTM IPLGSCTMKL NATSEMIPVT WPEFSQIHPF 550
APLDQTVGYR EMIDQLEAML CAATGYAAVS LQPNAGSQGE YAGLLIIHAY 600
HASRGESHRD ICLIPSSAHG TNPASAQMAG MKVVVVACDE DGNVDLQDLA 650
KKAEQHSKNL AAIMITYPST HGVFEQGVQQ ICEIVHQHGG QVYVDGANMN 700
AMVGTAAPGQ FGGDVSHLNL HKTFCIPHGG GGPGVGPVAV GAHLADFLPN 750
QDSVGYRRDD RGIGGVSAAP FGSASILPIS WMYIAMMGSA GLTAATENAI 800
LAANYVAKRL APYYPVLYTG QHDLVAHECI LDLRPLQKDT GISNEDVAKR 850
LMDYGFHAPT MSFPVPGTLM IEPTESEALH ELDRFIDAMI AIRQEIGRVA 900
DGTFDRDDNP LKHAPHTAAV VTADEWTHKY TREEAAYPVA SLRTQKYWPP 950
VGRADNVYGD RNLFCACVPV SDYVVD 976
Length:976
Mass (Da):104,999
Last modified:October 19, 2011 - v1
Checksum:iA9A9D4EC2E7B7DC2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002877 Genomic DNA. Translation: AEI78864.1.
RefSeqiYP_004687345.1. NC_015726.1.

Genome annotation databases

EnsemblBacteriaiAEI78864; AEI78864; CNE_1c35720.
GeneIDi10919963.
KEGGicnc:CNE_1c35720.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002877 Genomic DNA. Translation: AEI78864.1 .
RefSeqi YP_004687345.1. NC_015726.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEI78864 ; AEI78864 ; CNE_1c35720 .
GeneIDi 10919963.
KEGGi cnc:CNE_1c35720.

Phylogenomic databases

KOi K00281.

Enzyme and pathway databases

BioCyci CNEC1042878:GH0Z-3572-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete Genome Sequence of the Type Strain Cupriavidus necator N-1."
    Poehlein A., Kusian B., Friedrich B., Daniel R., Bowien B.
    J. Bacteriol. 193:5017-5017(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43291 / DSM 13513 / N-1.

Entry informationi

Entry nameiG0F028_CUPNN
AccessioniPrimary (citable) accession number: G0F028
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: July 9, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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