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G0ET24

- G0ET24_CUPNN

UniProt

G0ET24 - G0ET24_CUPNN

Protein

Kynureninase

Gene

kynU

Organism
Cupriavidus necator (strain ATCC 43291 / DSM 13513 / N-1) (Ralstonia eutropha)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei99 – 991Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei100 – 1001Pyridoxal phosphateUniRule annotation
    Binding sitei174 – 1741Pyridoxal phosphateUniRule annotation
    Binding sitei203 – 2031Pyridoxal phosphateUniRule annotation
    Binding sitei206 – 2061Pyridoxal phosphateUniRule annotation
    Binding sitei228 – 2281Pyridoxal phosphateUniRule annotation
    Binding sitei258 – 2581Pyridoxal phosphateUniRule annotation
    Binding sitei284 – 2841Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotationImported

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciCNEC1042878:GH0Z-2715-MONOMER.
    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    L-kynurenine hydrolaseUniRule annotation
    Gene namesi
    Name:kynUUniRule annotationImported
    Ordered Locus Names:CNE_1c27150Imported
    OrganismiCupriavidus necator (strain ATCC 43291 / DSM 13513 / N-1) (Ralstonia eutropha)Imported
    Taxonomic identifieri1042878 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
    ProteomesiUP000006798: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei229 – 2291N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni131 – 1344Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    KOiK01556.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    G0ET24-1 [UniParc]FASTAAdd to Basket

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    MTTFDREHCI RLDERDPLRP LRDQFALPEG VIYLDGNSLG ARPRAAAARA    50
    AQVVAEEWGE GLIRSWNTAG WFELPQRLGN KLAPLVGAGQ DEVVVTDTTS 100
    INLFKVLAAA LRVQQTRDPA RKVIVSEASN FPTDLYIAQG LADLLQQGYS 150
    LRLVNSPAEI DAAVGADTAV LMLTHVNYKT GEMLDMAALT DLAHARGALT 200
    VWDLCHSAGA VPVNLKAAGA DYAIGCTYKY LNGGPGSPAF VWVAPALRDA 250
    FWQPLSGWWG HAAPFAMEPQ YRPVDGVRRF LCGTQPVTSL AMVECGLDIF 300
    AQTTMQVLRA KSLLLTDLFI ELVEARCGHH PLTLVTPREH ARRGSQVSLE 350
    HPDGYALVQA LIERGVIGDY REPRIARFGF TPLYTSFTEV WDAVEILRDV 400
    LDSGAYRDAR FQTRGQVT 418
    Length:418
    Mass (Da):45,855
    Last modified:October 19, 2011 - v1
    Checksum:i6FECE4D46C5C085A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002877 Genomic DNA. Translation: AEI78030.1.
    RefSeqiYP_004686511.1. NC_015726.1.

    Genome annotation databases

    EnsemblBacteriaiAEI78030; AEI78030; CNE_1c27150.
    GeneIDi10919106.
    KEGGicnc:CNE_1c27150.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002877 Genomic DNA. Translation: AEI78030.1 .
    RefSeqi YP_004686511.1. NC_015726.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEI78030 ; AEI78030 ; CNE_1c27150 .
    GeneIDi 10919106.
    KEGGi cnc:CNE_1c27150.

    Phylogenomic databases

    KOi K01556.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .
    BioCyci CNEC1042878:GH0Z-2715-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the type strain Cupriavidus necator N-1."
      Poehlein A., Kusian B., Friedrich B., Daniel R., Bowien B.
      J. Bacteriol. 193:5017-5017(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43291 / DSM 13513 / N-1Imported.

    Entry informationi

    Entry nameiG0ET24_CUPNN
    AccessioniPrimary (citable) accession number: G0ET24
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 19, 2011
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3