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G0ET24

- G0ET24_CUPNN

UniProt

G0ET24 - G0ET24_CUPNN

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Protein

Kynureninase

Gene

kynU

Organism
Cupriavidus necator (strain ATCC 43291 / DSM 13513 / N-1) (Ralstonia eutropha)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei99 – 991Pyridoxal phosphate; via amide nitrogenUniRule annotation
Binding sitei100 – 1001Pyridoxal phosphateUniRule annotation
Binding sitei174 – 1741Pyridoxal phosphateUniRule annotation
Binding sitei203 – 2031Pyridoxal phosphateUniRule annotation
Binding sitei206 – 2061Pyridoxal phosphateUniRule annotation
Binding sitei228 – 2281Pyridoxal phosphateUniRule annotation
Binding sitei258 – 2581Pyridoxal phosphateUniRule annotation
Binding sitei284 – 2841Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciCNEC1042878:GH0Z-2715-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynUUniRule annotationImported
Ordered Locus Names:CNE_1c27150Imported
OrganismiCupriavidus necator (strain ATCC 43291 / DSM 13513 / N-1) (Ralstonia eutropha)Imported
Taxonomic identifieri1042878 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000006798: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei229 – 2291N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni131 – 1344Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

KOiK01556.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

G0ET24-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTFDREHCI RLDERDPLRP LRDQFALPEG VIYLDGNSLG ARPRAAAARA
60 70 80 90 100
AQVVAEEWGE GLIRSWNTAG WFELPQRLGN KLAPLVGAGQ DEVVVTDTTS
110 120 130 140 150
INLFKVLAAA LRVQQTRDPA RKVIVSEASN FPTDLYIAQG LADLLQQGYS
160 170 180 190 200
LRLVNSPAEI DAAVGADTAV LMLTHVNYKT GEMLDMAALT DLAHARGALT
210 220 230 240 250
VWDLCHSAGA VPVNLKAAGA DYAIGCTYKY LNGGPGSPAF VWVAPALRDA
260 270 280 290 300
FWQPLSGWWG HAAPFAMEPQ YRPVDGVRRF LCGTQPVTSL AMVECGLDIF
310 320 330 340 350
AQTTMQVLRA KSLLLTDLFI ELVEARCGHH PLTLVTPREH ARRGSQVSLE
360 370 380 390 400
HPDGYALVQA LIERGVIGDY REPRIARFGF TPLYTSFTEV WDAVEILRDV
410
LDSGAYRDAR FQTRGQVT
Length:418
Mass (Da):45,855
Last modified:October 19, 2011 - v1
Checksum:i6FECE4D46C5C085A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002877 Genomic DNA. Translation: AEI78030.1.
RefSeqiWP_013957611.1. NC_015726.1.
YP_004686511.1. NC_015726.1.

Genome annotation databases

EnsemblBacteriaiAEI78030; AEI78030; CNE_1c27150.
GeneIDi10919106.
KEGGicnc:CNE_1c27150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002877 Genomic DNA. Translation: AEI78030.1 .
RefSeqi WP_013957611.1. NC_015726.1.
YP_004686511.1. NC_015726.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEI78030 ; AEI78030 ; CNE_1c27150 .
GeneIDi 10919106.
KEGGi cnc:CNE_1c27150.

Phylogenomic databases

KOi K01556.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .
BioCyci CNEC1042878:GH0Z-2715-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the type strain Cupriavidus necator N-1."
    Poehlein A., Kusian B., Friedrich B., Daniel R., Bowien B.
    J. Bacteriol. 193:5017-5017(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43291 / DSM 13513 / N-1Imported.

Entry informationi

Entry nameiG0ET24_CUPNN
AccessioniPrimary (citable) accession number: G0ET24
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: October 29, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3