Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

G0EDM6

- G0EDM6_PYRF1

UniProt

G0EDM6 - G0EDM6_PYRF1

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

DNA ligase

Gene

lig

Organism
Pyrolobus fumarii (strain DSM 11204 / 1A)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei266 – 2661ATPUniRule annotation
Active sitei268 – 2681N6-AMP-lysine intermediateUniRule annotation
Binding sitei273 – 2731ATPUniRule annotation
Binding sitei288 – 2881ATPUniRule annotation
Binding sitei318 – 3181ATPUniRule annotation
Binding sitei358 – 3581ATPUniRule annotation
Binding sitei435 – 4351ATPUniRule annotation
Binding sitei441 – 4411ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciPFUM694429:GHUY-2028-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Pyrfu_1977Imported
OrganismiPyrolobus fumarii (strain DSM 11204 / 1A)Imported
Taxonomic identifieri694429 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesPyrodictiaceaePyrolobus
ProteomesiUP000001037: Chromosome

Structurei

3D structure databases

ProteinModelPortaliG0EDM6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OMAiMVKMLEG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G0EDM6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPMPFSILAE TFEKLERTTS RTQMVLYLVD LFKKTPPETI DKVVYFLQGK
60 70 80 90 100
LWPDWKGLPE LGVGEKTLIK AVSIALHVPE RTVEELAKRL GDLGLAVERL
110 120 130 140 150
KREKEKGAKA VGLLAFMKQP SSGESTLTVE KVYDTLARVA LTTGEGSREL
160 170 180 190 200
KLKLVAGLIA EASPREAKYI VRFIEGRLRL GVGDATIIEA LSIVYAGSAA
210 220 230 240 250
MKHVVERAYN LRADLGLVAK ILATQGVEAV KNIKPEVGIP IRPMLAERLN
260 270 280 290 300
NPVEILKKLG GRALVEYKYD GERAQIHKKG DKIWIFSRRL ENITKMYPDV
310 320 330 340 350
VEMALKGIKA NEAIVEGEIV AIDPDTGELR PFQELMRRKR KHDIHIAMKE
360 370 380 390 400
VPVAVYLFDI LYRDGEDLTV KPLPERRKHL EEVLVQSDTW RLAEHIYTDK
410 420 430 440 450
PEELEQFFLR AIEDGAEGVM AKAVHSRSIY QAGARGWLWI KYKRDYKSEM
460 470 480 490 500
IDTVDLVVVG AFYGKGRRGG KFGALLMAAY DPDTDTFKTV CKVGSGFTDE
510 520 530 540 550
DLERLNEMLK PYIIPHKHPR VDSKMKPDVW VQPALVAEII GAELTLSPIH
560 570 580 590 600
TCCHGWVKPG AGISIRFPRF IRWRPDKSPE DATTTKELYE MYKRQLHKIE

EKTATREAA
Length:609
Mass (Da):68,833
Last modified:October 19, 2011 - v1
Checksum:iF71A9C6F3BA53E90
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002838 Genomic DNA. Translation: AEM39830.1.
RefSeqiYP_004782082.1. NC_015931.1.

Genome annotation databases

EnsemblBacteriaiAEM39830; AEM39830; Pyrfu_1977.
GeneIDi11138318.
KEGGipfm:Pyrfu_1977.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002838 Genomic DNA. Translation: AEM39830.1 .
RefSeqi YP_004782082.1. NC_015931.1.

3D structure databases

ProteinModelPortali G0EDM6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEM39830 ; AEM39830 ; Pyrfu_1977 .
GeneIDi 11138318.
KEGGi pfm:Pyrfu_1977.

Phylogenomic databases

KOi K10747.
OMAi MVKMLEG.

Enzyme and pathway databases

BioCyci PFUM694429:GHUY-2028-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11204 / 1AImported.

Entry informationi

Entry nameiG0EDM6_PYRF1
AccessioniPrimary (citable) accession number: G0EDM6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: October 29, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3