Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

G0EDM6

- G0EDM6_PYRF1

UniProt

G0EDM6 - G0EDM6_PYRF1

Protein

DNA ligase

Gene

lig

Organism
Pyrolobus fumarii (strain DSM 11204 / 1A)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (19 Oct 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei266 – 2661ATPUniRule annotation
    Active sitei268 – 2681N6-AMP-lysine intermediateUniRule annotation
    Binding sitei273 – 2731ATPUniRule annotation
    Binding sitei288 – 2881ATPUniRule annotation
    Binding sitei318 – 3181ATPUniRule annotation
    Binding sitei358 – 3581ATPUniRule annotation
    Binding sitei435 – 4351ATPUniRule annotation
    Binding sitei441 – 4411ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPFUM694429:GHUY-2028-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Pyrfu_1977Imported
    OrganismiPyrolobus fumarii (strain DSM 11204 / 1A)Imported
    Taxonomic identifieri694429 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesPyrodictiaceaePyrolobus
    ProteomesiUP000001037: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliG0EDM6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10747.
    OMAiMVKMLEG.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G0EDM6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPMPFSILAE TFEKLERTTS RTQMVLYLVD LFKKTPPETI DKVVYFLQGK    50
    LWPDWKGLPE LGVGEKTLIK AVSIALHVPE RTVEELAKRL GDLGLAVERL 100
    KREKEKGAKA VGLLAFMKQP SSGESTLTVE KVYDTLARVA LTTGEGSREL 150
    KLKLVAGLIA EASPREAKYI VRFIEGRLRL GVGDATIIEA LSIVYAGSAA 200
    MKHVVERAYN LRADLGLVAK ILATQGVEAV KNIKPEVGIP IRPMLAERLN 250
    NPVEILKKLG GRALVEYKYD GERAQIHKKG DKIWIFSRRL ENITKMYPDV 300
    VEMALKGIKA NEAIVEGEIV AIDPDTGELR PFQELMRRKR KHDIHIAMKE 350
    VPVAVYLFDI LYRDGEDLTV KPLPERRKHL EEVLVQSDTW RLAEHIYTDK 400
    PEELEQFFLR AIEDGAEGVM AKAVHSRSIY QAGARGWLWI KYKRDYKSEM 450
    IDTVDLVVVG AFYGKGRRGG KFGALLMAAY DPDTDTFKTV CKVGSGFTDE 500
    DLERLNEMLK PYIIPHKHPR VDSKMKPDVW VQPALVAEII GAELTLSPIH 550
    TCCHGWVKPG AGISIRFPRF IRWRPDKSPE DATTTKELYE MYKRQLHKIE 600
    EKTATREAA 609
    Length:609
    Mass (Da):68,833
    Last modified:October 19, 2011 - v1
    Checksum:iF71A9C6F3BA53E90
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002838 Genomic DNA. Translation: AEM39830.1.
    RefSeqiWP_014027507.1. NC_015931.1.
    YP_004782082.1. NC_015931.1.

    Genome annotation databases

    EnsemblBacteriaiAEM39830; AEM39830; Pyrfu_1977.
    GeneIDi11138318.
    KEGGipfm:Pyrfu_1977.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002838 Genomic DNA. Translation: AEM39830.1 .
    RefSeqi WP_014027507.1. NC_015931.1.
    YP_004782082.1. NC_015931.1.

    3D structure databases

    ProteinModelPortali G0EDM6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEM39830 ; AEM39830 ; Pyrfu_1977 .
    GeneIDi 11138318.
    KEGGi pfm:Pyrfu_1977.

    Phylogenomic databases

    KOi K10747.
    OMAi MVKMLEG.

    Enzyme and pathway databases

    BioCyci PFUM694429:GHUY-2028-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 11204 / 1AImported.

    Entry informationi

    Entry nameiG0EDM6_PYRF1
    AccessioniPrimary (citable) accession number: G0EDM6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 19, 2011
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3