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G0DZL2

- G0DZL2_ENTAK

UniProt

G0DZL2 - G0DZL2_ENTAK

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Protein
Ribosomal RNA large subunit methyltransferase K/L
Gene
rlmL, EAE_15305
Organism
Enterobacter aerogenes (strain ATCC 13048 / DSM 30053 / JCM 1235 / KCTC 2190 / NBRC 13534 / NCIMB 10102 / NCTC 10006) (Aerobacter aerogenes)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(2069) in 23S rRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(2069) in 23S rRNA.UniRule annotationSAAS annotations
S-adenosyl-L-methionine + guanine(2445) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(2445) in 23S rRNA.UniRule annotationSAAS annotations

GO - Molecular functioni

  1. 23S rRNA (guanine(2445)-N(2))-methyltransferase activity Source: UniProtKB-HAMAP
  2. RNA binding Source: UniProtKB-HAMAP
  3. rRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

rRNA processingUniRule annotationSAAS annotations

Keywords - Ligandi

RNA-bindingUniRule annotationSAAS annotations, S-adenosyl-L-methionineUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciEAER1028307:GHNA-3125-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase K/LUniRule annotation
Gene namesi
Name:rlmLUniRule annotationImported
Ordered Locus Names:EAE_15305Imported
OrganismiEnterobacter aerogenes (strain ATCC 13048 / DSM 30053 / JCM 1235 / KCTC 2190 / NBRC 13534 / NCIMB 10102 / NCTC 10006) (Aerobacter aerogenes)Imported
Taxonomic identifieri1028307 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter
ProteomesiUP000008881: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 154112THUMP By similarityUniRule annotation
Add
BLAST

Sequence similaritiesi

Contains 1 THUMP domain.UniRule annotation
Contains THUMP domain.SAAS annotations

Phylogenomic databases

KOiK12297.
OMAiNKRGFKM.

Family and domain databases

Gene3Di3.40.50.150. 3 hits.
HAMAPiMF_01858. 23SrRNA_methyltr_KL.
InterProiIPR017244. 23SrRNA_methyltr_KL.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR002296. N12N6_MeTrfase.
IPR000241. RNA_methylase_dom.
IPR019614. SAM-dep_methyl-trfase.
IPR029063. SAM-dependent_MTases-like.
IPR004114. THUMP.
[Graphical view]
PfamiPF10672. Methyltrans_SAM. 1 hit.
PF02926. THUMP. 1 hit.
PF01170. UPF0020. 1 hit.
[Graphical view]
PIRSFiPIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
PRINTSiPR00507. N12N6MTFRASE.
SMARTiSM00981. THUMP. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 3 hits.
PROSITEiPS00092. N6_MTASE. 1 hit.
PS51165. THUMP. 1 hit.
PS01261. UPF0020. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G0DZL2-1 [UniParc]FASTAAdd to Basket

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MKSLFASTAR GLEELLKTEL EGLGATACQV VQGGVHFQGD TRLLYQSLMW    50
SRLASRIMLP LGECSVYSDL DLYLGVQSIP WTEIFTTDAT FAVHFSGLNE 100
EIRNSQYGAL KVKDAIVDSF TRKNLPRPNV DRENPDLRIN VWLNKETAHI 150
SLDLSGEGLH LRGYRDGTGM APIKENLAAA IVMRSGWVAG TPLLDPMCGS 200
GTLLIEAAML ATDRAPGLHR GHWGFGGWAQ HDDAIWKEVK AEAQTRARQG 250
LAAYESRFYG SDVDERVIER ARRNARRAGI GELINFEVKD VAQLNNPLPK 300
GPYGTVISNP PYGERLESEP ALIALHSLLG RIMKNQFGGW NLSVFSASPE 350
LLSCLQLRAD KQFKAKNGPL DCVQKNYHLA ESEGGKPAML AEDFANRLRK 400
NLKKFEKWAR QEGIECYRLY DADLPEYNVA IDRYGEWVVV QEYAPPKTVD 450
AHKARQRLFD IIAATIAVLG IAPNKLVLKT RERQKGKNQY QKMAEKGDFI 500
EVQEYNARLW VNLTDYLDTG LFLDHRIARC MLGQMSKGKD FLNLFSYTGS 550
ASVHAGLGGA RSTTTVDMSR TYLEWAERNL RLNGLTGRAH RLMQADVLGW 600
LRESTEQFDL IFIDPPTFSN SKRMEDAFDV QRDHIRLMTD LKRLLRKGGT 650
IMFSNNKRGF RMDHDGLAAL GLKAQEISQK TLSQDFARNR QIHNCWLITA 700
A 701
Length:701
Mass (Da):78,843
Last modified:October 19, 2011 - v1
Checksum:iA912936E9126B028
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002824 Genomic DNA. Translation: AEG97974.1.
RefSeqiYP_004593253.1. NC_015663.1.

Genome annotation databases

EnsemblBacteriaiAEG97974; AEG97974; EAE_15305.
GeneIDi10793283.
KEGGieae:EAE_15305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002824 Genomic DNA. Translation: AEG97974.1 .
RefSeqi YP_004593253.1. NC_015663.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEG97974 ; AEG97974 ; EAE_15305 .
GeneIDi 10793283.
KEGGi eae:EAE_15305.

Phylogenomic databases

KOi K12297.
OMAi NKRGFKM.

Enzyme and pathway databases

BioCyci EAER1028307:GHNA-3125-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 3 hits.
HAMAPi MF_01858. 23SrRNA_methyltr_KL.
InterProi IPR017244. 23SrRNA_methyltr_KL.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR002296. N12N6_MeTrfase.
IPR000241. RNA_methylase_dom.
IPR019614. SAM-dep_methyl-trfase.
IPR029063. SAM-dependent_MTases-like.
IPR004114. THUMP.
[Graphical view ]
Pfami PF10672. Methyltrans_SAM. 1 hit.
PF02926. THUMP. 1 hit.
PF01170. UPF0020. 1 hit.
[Graphical view ]
PIRSFi PIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
PRINTSi PR00507. N12N6MTFRASE.
SMARTi SM00981. THUMP. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 3 hits.
PROSITEi PS00092. N6_MTASE. 1 hit.
PS51165. THUMP. 1 hit.
PS01261. UPF0020. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Enterobacter aerogenes KCTC 2190."
    Shin S.H., Kim S., Kim J.Y., Yang K.-S., Seo J.-S.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13048 / DSM 30053 / JCM 1235 / KCTC 2190 / NBRC 13534 / NCIMB 10102 / NCTC 10006.

Entry informationi

Entry nameiG0DZL2_ENTAK
AccessioniPrimary (citable) accession number: G0DZL2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: June 11, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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