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G0DZL2

- G0DZL2_ENTAK

UniProt

G0DZL2 - G0DZL2_ENTAK

Protein

Ribosomal RNA large subunit methyltransferase K/L

Gene

rlmL

Organism
Enterobacter aerogenes (strain ATCC 13048 / DSM 30053 / JCM 1235 / KCTC 2190 / NBRC 13534 / NCIMB 10102 / NCTC 10006) (Aerobacter aerogenes)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(2069) in 23S rRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(2069) in 23S rRNA.UniRule annotationSAAS annotation
    S-adenosyl-L-methionine + guanine(2445) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(2445) in 23S rRNA.UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. 23S rRNA (guanine(2445)-N(2))-methyltransferase activity Source: UniProtKB-HAMAP
    2. RNA binding Source: UniProtKB-HAMAP
    3. rRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    MethyltransferaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    rRNA processingUniRule annotationSAAS annotation

    Keywords - Ligandi

    RNA-bindingUniRule annotationSAAS annotation, S-adenosyl-L-methionineUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciEAER1028307:GHNA-3125-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal RNA large subunit methyltransferase K/LUniRule annotation
    Gene namesi
    Name:rlmLUniRule annotationImported
    Ordered Locus Names:EAE_15305Imported
    OrganismiEnterobacter aerogenes (strain ATCC 13048 / DSM 30053 / JCM 1235 / KCTC 2190 / NBRC 13534 / NCIMB 10102 / NCTC 10006) (Aerobacter aerogenes)Imported
    Taxonomic identifieri1028307 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter
    ProteomesiUP000008881: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini43 – 154112THUMPUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the methyltransferase superfamily. RlmKL family.UniRule annotation
    Contains 1 THUMP domain.UniRule annotation
    Contains THUMP domain.SAAS annotation

    Phylogenomic databases

    KOiK12297.
    OMAiNKRGFKM.

    Family and domain databases

    Gene3Di3.40.50.150. 3 hits.
    HAMAPiMF_01858. 23SrRNA_methyltr_KL.
    InterProiIPR017244. 23SrRNA_methyltr_KL.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR002296. N12N6_MeTrfase.
    IPR000241. RNA_methylase_dom.
    IPR019614. SAM-dep_methyl-trfase.
    IPR029063. SAM-dependent_MTases-like.
    IPR004114. THUMP.
    [Graphical view]
    PfamiPF10672. Methyltrans_SAM. 1 hit.
    PF02926. THUMP. 1 hit.
    PF01170. UPF0020. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
    PRINTSiPR00507. N12N6MTFRASE.
    SMARTiSM00981. THUMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 3 hits.
    PROSITEiPS00092. N6_MTASE. 1 hit.
    PS51165. THUMP. 1 hit.
    PS01261. UPF0020. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G0DZL2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSLFASTAR GLEELLKTEL EGLGATACQV VQGGVHFQGD TRLLYQSLMW    50
    SRLASRIMLP LGECSVYSDL DLYLGVQSIP WTEIFTTDAT FAVHFSGLNE 100
    EIRNSQYGAL KVKDAIVDSF TRKNLPRPNV DRENPDLRIN VWLNKETAHI 150
    SLDLSGEGLH LRGYRDGTGM APIKENLAAA IVMRSGWVAG TPLLDPMCGS 200
    GTLLIEAAML ATDRAPGLHR GHWGFGGWAQ HDDAIWKEVK AEAQTRARQG 250
    LAAYESRFYG SDVDERVIER ARRNARRAGI GELINFEVKD VAQLNNPLPK 300
    GPYGTVISNP PYGERLESEP ALIALHSLLG RIMKNQFGGW NLSVFSASPE 350
    LLSCLQLRAD KQFKAKNGPL DCVQKNYHLA ESEGGKPAML AEDFANRLRK 400
    NLKKFEKWAR QEGIECYRLY DADLPEYNVA IDRYGEWVVV QEYAPPKTVD 450
    AHKARQRLFD IIAATIAVLG IAPNKLVLKT RERQKGKNQY QKMAEKGDFI 500
    EVQEYNARLW VNLTDYLDTG LFLDHRIARC MLGQMSKGKD FLNLFSYTGS 550
    ASVHAGLGGA RSTTTVDMSR TYLEWAERNL RLNGLTGRAH RLMQADVLGW 600
    LRESTEQFDL IFIDPPTFSN SKRMEDAFDV QRDHIRLMTD LKRLLRKGGT 650
    IMFSNNKRGF RMDHDGLAAL GLKAQEISQK TLSQDFARNR QIHNCWLITA 700
    A 701
    Length:701
    Mass (Da):78,843
    Last modified:October 19, 2011 - v1
    Checksum:iA912936E9126B028
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002824 Genomic DNA. Translation: AEG97974.1.
    RefSeqiYP_004593253.1. NC_015663.1.

    Genome annotation databases

    EnsemblBacteriaiAEG97974; AEG97974; EAE_15305.
    GeneIDi10793283.
    KEGGieae:EAE_15305.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002824 Genomic DNA. Translation: AEG97974.1 .
    RefSeqi YP_004593253.1. NC_015663.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEG97974 ; AEG97974 ; EAE_15305 .
    GeneIDi 10793283.
    KEGGi eae:EAE_15305.

    Phylogenomic databases

    KOi K12297.
    OMAi NKRGFKM.

    Enzyme and pathway databases

    BioCyci EAER1028307:GHNA-3125-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 3 hits.
    HAMAPi MF_01858. 23SrRNA_methyltr_KL.
    InterProi IPR017244. 23SrRNA_methyltr_KL.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR002296. N12N6_MeTrfase.
    IPR000241. RNA_methylase_dom.
    IPR019614. SAM-dep_methyl-trfase.
    IPR029063. SAM-dependent_MTases-like.
    IPR004114. THUMP.
    [Graphical view ]
    Pfami PF10672. Methyltrans_SAM. 1 hit.
    PF02926. THUMP. 1 hit.
    PF01170. UPF0020. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
    PRINTSi PR00507. N12N6MTFRASE.
    SMARTi SM00981. THUMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 3 hits.
    PROSITEi PS00092. N6_MTASE. 1 hit.
    PS51165. THUMP. 1 hit.
    PS01261. UPF0020. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Enterobacter aerogenes KCTC 2190."
      Shin S.H., Kim S., Kim J.Y., Yang K.-S., Seo J.-S.
      Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13048 / DSM 30053 / JCM 1235 / KCTC 2190 / NBRC 13534 / NCIMB 10102 / NCTC 10006Imported.

    Entry informationi

    Entry nameiG0DZL2_ENTAK
    AccessioniPrimary (citable) accession number: G0DZL2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 19, 2011
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3