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G0DCH8 (G0DCH8_ECOLX) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 7. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
dITP/XTP pyrophosphatase HAMAP-Rule MF_01405
EC=3.6.1.19 HAMAP-Rule MF_01405
Alternative name(s):
Non-canonical purine NTP pyrophosphatase HAMAP-Rule MF_01405
Non-standard purine NTP pyrophosphatase HAMAP-Rule MF_01405
Nucleoside-triphosphate diphosphatase HAMAP-Rule MF_01405
Nucleoside-triphosphate pyrophosphatase HAMAP-Rule MF_01405
Gene names
Name:rdgB HAMAP-Rule MF_01405
ORF Names:ECNA114_3002 EMBL AEG37841.1
OrganismEscherichia coli NA114 EMBL AEG37841.1
Taxonomic identifier1033813 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length197 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides deoxyinosine triphosphate (dITP) and xanthosine triphosphate (XTP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) to their respective monophosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP-Rule MF_01405

Catalytic activity

A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP-Rule MF_01405 SAAS SAAS020922

Cofactor

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity. HAMAP-Rule MF_01405 SAAS SAAS020922

Subunit structure

Homodimer By similarity. SAAS SAAS020922 HAMAP-Rule MF_01405

Sequence similarities

Belongs to the HAM1 NTPase family. RuleBase RU003781 HAMAP-Rule MF_01405

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region8 – 136Substrate binding By similarity HAMAP-Rule MF_01405
Region69 – 702Substrate binding By similarity HAMAP-Rule MF_01405

Sites

Metal binding401Magnesium or manganese By similarity HAMAP-Rule MF_01405
Metal binding691Magnesium or manganese By similarity HAMAP-Rule MF_01405
Binding site1571Substrate By similarity HAMAP-Rule MF_01405
Binding site1771Substrate By similarity HAMAP-Rule MF_01405
Binding site1831Substrate By similarity HAMAP-Rule MF_01405

Sequences

Sequence LengthMass (Da)Tools
G0DCH8 [UniParc].

Last modified October 19, 2011. Version 1.
Checksum: 51D0AC5EB9A16491

FASTA19720,997
        10         20         30         40         50         60 
MQKVVLATGN AGKVRELASL LSDFGLDIVA QTDLGVDSAE ETGLTFIENA ILKARHAAKV 

        70         80         90        100        110        120 
TGLPAIADDS GLAVDVLGGA PGIYSARYSG EDATDQKNLQ KLLETMKDVP DDQRQARFHC 

       130        140        150        160        170        180 
VLVYLRHAED PTPLVCHGSW PGVITREPAG TGGFGYDPIF FVPSEGKTAA ELTREEKSAI 

       190 
SHRGQALKLL LDALRNG

« Hide

References

[1]"Genome of Multidrug-Resistant Uropathogenic Escherichia coli Strain NA114 from India."
Avasthi T.S., Kumar N., Baddam R., Hussain A., Nandanwar N., Jadhav S., Ahmed N.
J. Bacteriol. 193:4272-4273(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NA114 EMBL AEG37841.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002797 Genomic DNA. Translation: AEG37841.1.
RefSeqYP_006140115.1. NC_017644.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEG37841; AEG37841; ECNA114_3002.
GeneID12681245.
KEGGena:ECNA114_3002.

Phylogenomic databases

KOK02428.

Family and domain databases

HAMAPMF_01405. Non_canon_purine_NTPase.
InterProIPR002637. Ham1p-like.
IPR020922. Nucleoside-triphosphatase.
[Graphical view]
PANTHERPTHR11067. PTHR11067. 1 hit.
PfamPF01725. Ham1p_like. 1 hit.
[Graphical view]
TIGRFAMsTIGR00042. TIGR00042. 1 hit.
ProtoNetSearch...

Entry information

Entry nameG0DCH8_ECOLX
AccessionPrimary (citable) accession number: G0DCH8
Entry history
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: April 3, 2013
This is version 7 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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