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Protein

Glutamate decarboxylase

Gene

gadA

Organism
Escherichia coli NA114
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciECOL1033813:GI9U-3750-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Name:gadAImported
ORF Names:ECNA114_3664Imported
OrganismiEscherichia coli NA114Imported
Taxonomic identifieri1033813 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000008885: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

KOiK01580.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 2 hits.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G0D5U1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQKLLTDFR SELLDSRFGA KAISTIAESK RFPLHEMRDD VAFQIINDEL
60 70 80 90 100
YLDGNARQNL ATFCQTWDDE NVHKLMDLSI NNLATFCQTW DDENVHKLMD
110 120 130 140 150
LSINKNWIDK EEYPQSAAID LRCVNMVADL WHAPAPKNGQ AVGTNTIGSS
160 170 180 190 200
EACMLGGMAM KWRWRKRMEA AGKPTDKPNL VCGPVQICWH KFARYWDVEL
210 220 230 240 250
REIPMRPGQL FMDPKRMIEA CDENTIGVVP TFGVTYTGNY EFPQPLHDAL
260 270 280 290 300
DKFQADTGID IDMHLPQELV FNVDYLGGQI GAPDIVWDFR LPRVKSISAS
310 320 330 340 350
GHKFGLAPLG CGWVIWRDEE ALPQELVFNV DYLGGQIGTF AINFSRPAGQ
360 370 380 390 400
VIAQYYEFLR LGREGYTKVQ NASYQVAAYL ADEIAKLGPY EFICTGRPDE
410 420 430 440 450
GIPAVCFKLK DGEDPGYTLY DLSERLRLRG WQVPAFTLGG EATDIVVMRI
460 470 480 490
MCRRGFEMDF AELLLEDYKA SLKYLSDHPK LQGIAQQNSF KHT
Length:493
Mass (Da):55,973
Last modified:October 19, 2011 - v1
Checksum:i2647B671C5FC70C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002797 Genomic DNA. Translation: AEG38504.1.
RefSeqiYP_006140778.1. NC_017644.1.

Genome annotation databases

EnsemblBacteriaiAEG38504; AEG38504; ECNA114_3664.
GeneIDi12681927.
KEGGiena:ECNA114_3664.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002797 Genomic DNA. Translation: AEG38504.1.
RefSeqiYP_006140778.1. NC_017644.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEG38504; AEG38504; ECNA114_3664.
GeneIDi12681927.
KEGGiena:ECNA114_3664.

Phylogenomic databases

KOiK01580.

Enzyme and pathway databases

BioCyciECOL1033813:GI9U-3750-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 2 hits.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome of multidrug-resistant uropathogenic Escherichia coli strain NA114 from India."
    Avasthi T.S., Kumar N., Baddam R., Hussain A., Nandanwar N., Jadhav S., Ahmed N.
    J. Bacteriol. 193:4272-4273(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NA114Imported.

Entry informationi

Entry nameiG0D5U1_ECOLX
AccessioniPrimary (citable) accession number: G0D5U1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: March 4, 2015
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.