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G0CXJ7 (G0CXJ7_CORUB) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138

EC=6.3.4.13 HAMAP-Rule MF_00138
Alternative name(s):
GARS HAMAP-Rule MF_00138
Glycinamide ribonucleotide synthetase HAMAP-Rule MF_00138
Phosphoribosylglycinamide synthetase HAMAP-Rule MF_00138
Gene names
Name:purD HAMAP-Rule MF_00138 EMBL AEG84617.1
Ordered Locus Names:CULC22_01912 EMBL AEG84617.1
OrganismCorynebacterium ulcerans (strain BR-AD22) [Complete proteome] [HAMAP] EMBL AEG84617.1
Taxonomic identifier945712 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. HAMAP-Rule MF_00138

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family. HAMAP-Rule MF_00138

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00138

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain113 – 316204ATP-grasp By similarity HAMAP-Rule MF_00138
Nucleotide binding142 – 19756ATP By similarity HAMAP-Rule MF_00138

Sites

Metal binding2861Magnesium or manganese By similarity HAMAP-Rule MF_00138
Metal binding2881Magnesium or manganese By similarity HAMAP-Rule MF_00138

Sequences

Sequence LengthMass (Da)Tools
G0CXJ7 [UniParc].

Last modified October 19, 2011. Version 1.
Checksum: 3F1D741997EFF089

FASTA42644,483
        10         20         30         40         50         60 
MIRIMHILVI GSGAREHALA LGLSKDPAVT ELHVAPGNVG MESIATVHSE ATQVDNPDEM 

        70         80         90        100        110        120 
LKVAQEVRAD LVVIGPEIPL VAGVADTLRA HGFAVFGPNK DAARIEGSKA FAKDVMAKAG 

       130        140        150        160        170        180 
VKTARAEQIA PGASDAQREA ALDNFGPHYV VKDDGLAGGK GVVVTKDRAQ ARAHVDAVLA 

       190        200        210        220        230        240 
AGNPVLLESF LDGPEVSLFC LVDGETVVPL LPAQDHKRAF DNDEGPNTGG MGAYTPLPWL 

       250        260        270        280        290        300 
PEDGVQRIVD EVCIPVAREM VARGCAYSGL LYAGIAWGEE GPAVVEFNCR FGDPETQAVV 

       310        320        330        340        350        360 
ALLQSPLAEV LNAVATGKLA ELPPLEWEDG FALTVVLAAE GYPESPRKGG EINGADDAAV 

       370        380        390        400        410        420 
LHAGTAYDAD GKLVAAGGRV LNVIGTGASL IDARRNAYNV LDKITLPGSH YRSDIALPAV 


EENIMI 

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References

[1]"Comparative analysis of two complete Corynebacterium ulcerans genomes and detection of candidate virulence factors."
Trost E., Al-Dilaimi A., Papavasiliou P., Schneider J., Viehoever P., Burkovski A., Soares S.C., Almeida S.S., Dorella F.A., Miyoshi A., Azevedo V., Schneider M.P., Silva A., Santos C.S., Santos L.S., Sabbadini P., Dias A.A., Hirata R.Jr., Mattos-Guaraldi A.L., Tauch A.
BMC Genomics 12:383-383(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BR-AD22 EMBL AEG84617.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002791 Genomic DNA. Translation: AEG84617.1.
RefSeqYP_004630536.1. NC_015683.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEG84617; AEG84617; CULC22_01912.
GeneID10844503.
KEGGcul:CULC22_01912.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01945.

Enzyme and pathway databases

BioCycCULC945712:GHG6-1958-MONOMER.
UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG0CXJ7_CORUB
AccessionPrimary (citable) accession number: G0CXJ7
Entry history
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: February 19, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)