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G0CXJ7

- G0CXJ7_CORUB

UniProt

G0CXJ7 - G0CXJ7_CORUB

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Protein
Phosphoribosylamine--glycine ligase
Gene
purD, CULC22_01912
Organism
Corynebacterium ulcerans (strain BR-AD22)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi286 – 2861Magnesium or manganese By similarityUniRule annotation
Metal bindingi288 – 2881Magnesium or manganese By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi142 – 19756ATP By similarityUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. manganese ion binding Source: UniProtKB-HAMAP
  4. phosphoribosylamine-glycine ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
  2. purine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Purine biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciCULC945712:GHG6-1958-MONOMER.
UniPathwayiUPA00074; UER00125.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylamine--glycine ligaseUniRule annotation (EC:6.3.4.13UniRule annotation)
Alternative name(s):
GARS
Glycinamide ribonucleotide synthetase
Phosphoribosylglycinamide synthetase
Gene namesi
Name:purDUniRule annotationImported
Ordered Locus Names:CULC22_01912Imported
OrganismiCorynebacterium ulcerans (strain BR-AD22)Imported
Taxonomic identifieri945712 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000008887: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini113 – 316204ATP-grasp By similarityUniRule annotation
Add
BLAST

Sequence similaritiesi

Belongs to the GARS family.UniRule annotation
Contains 1 ATP-grasp domain.UniRule annotation

Phylogenomic databases

KOiK01945.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPiMF_00138. GARS.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR00877. purD. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G0CXJ7-1 [UniParc]FASTAAdd to Basket

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MIRIMHILVI GSGAREHALA LGLSKDPAVT ELHVAPGNVG MESIATVHSE    50
ATQVDNPDEM LKVAQEVRAD LVVIGPEIPL VAGVADTLRA HGFAVFGPNK 100
DAARIEGSKA FAKDVMAKAG VKTARAEQIA PGASDAQREA ALDNFGPHYV 150
VKDDGLAGGK GVVVTKDRAQ ARAHVDAVLA AGNPVLLESF LDGPEVSLFC 200
LVDGETVVPL LPAQDHKRAF DNDEGPNTGG MGAYTPLPWL PEDGVQRIVD 250
EVCIPVAREM VARGCAYSGL LYAGIAWGEE GPAVVEFNCR FGDPETQAVV 300
ALLQSPLAEV LNAVATGKLA ELPPLEWEDG FALTVVLAAE GYPESPRKGG 350
EINGADDAAV LHAGTAYDAD GKLVAAGGRV LNVIGTGASL IDARRNAYNV 400
LDKITLPGSH YRSDIALPAV EENIMI 426
Length:426
Mass (Da):44,483
Last modified:October 19, 2011 - v1
Checksum:i3F1D741997EFF089
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002791 Genomic DNA. Translation: AEG84617.1.
RefSeqiYP_004630536.1. NC_015683.1.

Genome annotation databases

EnsemblBacteriaiAEG84617; AEG84617; CULC22_01912.
GeneIDi10844503.
KEGGicul:CULC22_01912.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002791 Genomic DNA. Translation: AEG84617.1 .
RefSeqi YP_004630536.1. NC_015683.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEG84617 ; AEG84617 ; CULC22_01912 .
GeneIDi 10844503.
KEGGi cul:CULC22_01912.

Phylogenomic databases

KOi K01945.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00125 .
BioCyci CULC945712:GHG6-1958-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPi MF_00138. GARS.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view ]
Pfami PF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR00877. purD. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BR-AD22Imported.

Entry informationi

Entry nameiG0CXJ7_CORUB
AccessioniPrimary (citable) accession number: G0CXJ7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: June 11, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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