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G0C9K0 (G0C9K0_XANCA) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800 HAMAP-Rule MF_01970

Catalytic activity

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800 HAMAP-Rule MF_01970

L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800 HAMAP-Rule MF_01970

Cofactor

Pyridoxal phosphate By similarity. PIRNR PIRNR038800 HAMAP-Rule MF_01970

Pathway

Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800 HAMAP-Rule MF_01970

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800 HAMAP-Rule MF_01970

Subunit structure

Homodimer By similarity. PIRNR PIRNR038800 HAMAP-Rule MF_01970

Sequence similarities

Belongs to the kynureninase family. PIRNR PIRNR038800 HAMAP-Rule MF_01970

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region134 – 1374Pyridoxal phosphate binding By similarity HAMAP-Rule MF_01970

Sites

Binding site1061Pyridoxal phosphate; via amide nitrogen By similarity HAMAP-Rule MF_01970
Binding site1071Pyridoxal phosphate By similarity HAMAP-Rule MF_01970
Binding site2191Pyridoxal phosphate By similarity HAMAP-Rule MF_01970
Binding site2221Pyridoxal phosphate By similarity HAMAP-Rule MF_01970
Binding site2441Pyridoxal phosphate By similarity HAMAP-Rule MF_01970
Binding site2741Pyridoxal phosphate By similarity HAMAP-Rule MF_01970
Binding site3021Pyridoxal phosphate By similarity HAMAP-Rule MF_01970

Amino acid modifications

Modified residue2451N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01970

Sequences

Sequence LengthMass (Da)Tools
G0C9K0 [UniParc].

Last modified October 19, 2011. Version 1.
Checksum: F733411962733F70

FASTA42446,279
        10         20         30         40         50         60 
MMTDPLSRSH AAVLDAADPL RALRDAFVFP QHGGQDQTYF VGNSLGLQPR QARAMVYEVL 

        70         80         90        100        110        120 
DQWGALAVEG HFTGPTQWLT YHQLVRDGLA RVVGAHPGEV VAMNTLSVNL HLMMASFYRP 

       130        140        150        160        170        180 
TSERGAILIE AGAFPSDRHA VESQLRLHGL DPATQLIEVD ADAPDGTLSM AAIADAIARH 

       190        200        210        220        230        240 
GRRLALVLWP GIQYRTGQAF DLGEIARLAR AQGAAVGFDL AHAVGNIPLT LHDDGADFAV 

       250        260        270        280        290        300 
WCHYKYLNAG PGAVGGCFVH ARHATSDLPR MAGWWGHQQQ TRFRMDPQFV PTPGAEGWQL 

       310        320        330        340        350        360 
SNPPVLALAP LRASLDLFDQ AGMAALRAKS EQLTGHLEQL IHARLRQVLQ IVTPAEPARR 

       370        380        390        400        410        420 
GCQLSLRVAG GRTQGRALFD HLHAAGVLGD WREPDVIRIA PVPLYNRFSD LHTFVEQVEA 


WAAR 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002789 Genomic DNA. Translation: AEL06727.1.
RefSeqYP_005636845.1. NC_017271.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEL06727; AEL06727; XCR_1831.
GeneID12264483.
KEGGxcp:XCR_1831.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01556.

Enzyme and pathway databases

BioCycXCAM990315:GLMR-1827-MONOMER.
UniPathwayUPA00253; UER00329.
UPA00334; UER00455.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPMF_01970. Kynureninase.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR14084. PTHR14084. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF038800. KYNU. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR01814. kynureninase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameG0C9K0_XANCA
AccessionPrimary (citable) accession number: G0C9K0
Entry history
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: February 19, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)