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G0C9K0

- G0C9K0_XANCA

UniProt

G0C9K0 - G0C9K0_XANCA

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Protein
Kynureninase
Gene
kynU, XCR_1831
Organism
Xanthomonas campestris pv. raphani 756C
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei106 – 1061Pyridoxal phosphate; via amide nitrogen By similarityUniRule annotation
Binding sitei107 – 1071Pyridoxal phosphate By similarityUniRule annotation
Binding sitei219 – 2191Pyridoxal phosphate By similarityUniRule annotation
Binding sitei222 – 2221Pyridoxal phosphate By similarityUniRule annotation
Binding sitei244 – 2441Pyridoxal phosphate By similarityUniRule annotation
Binding sitei274 – 2741Pyridoxal phosphate By similarityUniRule annotation
Binding sitei302 – 3021Pyridoxal phosphate By similarityUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  3. anthranilate metabolic process Source: UniProtKB-HAMAP
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciXCAM990315:GLMR-1827-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolase
Gene namesi
Name:kynUUniRule annotationImported
ORF Names:XCR_1831Imported
OrganismiXanthomonas campestris pv. raphani 756CImported
Taxonomic identifieri990315 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000001633: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei245 – 2451N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1374Pyridoxal phosphate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK01556.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

G0C9K0-1 [UniParc]FASTAAdd to Basket

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MMTDPLSRSH AAVLDAADPL RALRDAFVFP QHGGQDQTYF VGNSLGLQPR    50
QARAMVYEVL DQWGALAVEG HFTGPTQWLT YHQLVRDGLA RVVGAHPGEV 100
VAMNTLSVNL HLMMASFYRP TSERGAILIE AGAFPSDRHA VESQLRLHGL 150
DPATQLIEVD ADAPDGTLSM AAIADAIARH GRRLALVLWP GIQYRTGQAF 200
DLGEIARLAR AQGAAVGFDL AHAVGNIPLT LHDDGADFAV WCHYKYLNAG 250
PGAVGGCFVH ARHATSDLPR MAGWWGHQQQ TRFRMDPQFV PTPGAEGWQL 300
SNPPVLALAP LRASLDLFDQ AGMAALRAKS EQLTGHLEQL IHARLRQVLQ 350
IVTPAEPARR GCQLSLRVAG GRTQGRALFD HLHAAGVLGD WREPDVIRIA 400
PVPLYNRFSD LHTFVEQVEA WAAR 424
Length:424
Mass (Da):46,279
Last modified:October 19, 2011 - v1
Checksum:iF733411962733F70
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002789 Genomic DNA. Translation: AEL06727.1.
RefSeqiYP_005636845.1. NC_017271.1.

Genome annotation databases

EnsemblBacteriaiAEL06727; AEL06727; XCR_1831.
GeneIDi12264483.
KEGGixcp:XCR_1831.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002789 Genomic DNA. Translation: AEL06727.1 .
RefSeqi YP_005636845.1. NC_017271.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEL06727 ; AEL06727 ; XCR_1831 .
GeneIDi 12264483.
KEGGi xcp:XCR_1831.

Phylogenomic databases

KOi K01556.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .
BioCyci XCAM990315:GLMR-1827-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 756CImported.

Entry informationi

Entry nameiG0C9K0_XANCA
AccessioniPrimary (citable) accession number: G0C9K0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: July 9, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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