G0BI87 (G0BI87_9ENTR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Tryptophan synthase beta chain HAMAP-Rule MF_00133
EC=4.2.1.20 HAMAP-Rule MF_00133

Gene names

Name:	trpB HAMAP-Rule MF_00133
ORF Names:	SerAS12_2666 EMBL AEF50737.1

Organism

Serratia sp. AS12 EMBL AEF50737.1

Taxonomic identifier

768490 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Serratia

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine By similarity. SAAS SAAS006654 HAMAP-Rule MF_00133
Catalytic activity	L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. SAAS SAAS006654 HAMAP-Rule MF_00133
Cofactor	Pyridoxal phosphate By similarity. SAAS SAAS006654 HAMAP-Rule MF_00133
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5. SAAS SAAS006654 HAMAP-Rule MF_00133
Subunit structure	Tetramer of two alpha and two beta chains By similarity. SAAS SAAS006654 HAMAP-Rule MF_00133
Sequence similarities	Belongs to the TrpB family. HAMAP-Rule MF_00133

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis SAAS SAAS006654 HAMAP-Rule MF_00133
Ligand	Pyridoxal phosphate SAAS SAAS006654 RuleBase RU003663 HAMAP-Rule MF_00133
Molecular function	Lyase SAAS SAAS006654 HAMAP-Rule MF_00133 EMBL AEF50737.1
Gene Ontology (GO)
Molecular_function	tryptophan synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Modified residue	86	1	N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_00133

Sequences

	Sequence		Length	Mass (Da)
	G0BI87 [UniParc]. Last modified October 19, 2011. Version 1. Checksum: 460190A36587A3EA	FASTA	396	42,810
	10 20 30 40 50 60 MTLLNPYFGE FGGQYVPQIL MPALKQLEEA FVSAQRDPEF QAEFIDLLKN YAGRPTALTL 70 80 90 100 110 120 CKNLTAGTKT KLYLKREDLL HGGAHKTNQV LGQALLAKRM GKTEIIAETG AGQHGVASAL 130 140 150 160 170 180 ACALLGLKCR IYMGAKDIER QSPNVFRMRL MGAEVIPVHS GSSTLKDACN EALRDWSGSY 190 200 210 220 230 240 ETAHYMLGTA AGPHPYPTIV REFQRMIGEE TKAQMLEREG RLPDAVLACV GGGSNAIGMF 250 260 270 280 290 300 ADFIDDVSVG LIGVEPAGLG IETGQHGAPL KHGHVGIYFG MKAPMMQTSE GQIEESYSIS 310 320 330 340 350 360 AGLDFPSVGP QHAYLNSIGR AEYVSITDDE ALDAFKALSR SEGIIPALES SHALAHALKM 370 380 390 IRETPQKEQI LVVNLSGRGD KDIFTVHDIL KARGEI

References

[1]

"Complete sequence of Serratia sp. AS12." US DOE Joint Genome Institute Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Ovchinnikova G., Chertkov O., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Neupane S., Alstrom S. , Finlay R., Hogberg N., Woyke T. Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: AS12 EMBL AEF50737.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002774 Genomic DNA. Translation: AEF50737.1.
RefSeq	YP_004501094.1. NC_015566.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AEF50737; AEF50737; SerAS12_2666.
GeneID	10626822.
KEGG	srs:SerAS12_2666.
Phylogenomic databases
KO	K01696.
Enzyme and pathway databases
UniPathway	UPA00035; UER00044.
Family and domain databases
HAMAP	MF_00133. Trp_synth_beta.
InterPro	IPR001926. Trp_syn_b_sub_like_PLP_eny_SF. IPR006653. Trp_synth_b_CS. IPR006654. Trp_synth_beta. IPR023026. Trp_synth_beta/beta-like. [Graphical view]
PANTHER	PTHR10314:SF3. PTHR10314:SF3. 1 hit.
Pfam	PF00291. PALP. 1 hit. [Graphical view]
PIRSF	PIRSF001413. Trp_syn_beta. 1 hit.
SUPFAM	SSF53686. PyrdxlP-dep_enz_bsu. 1 hit.
TIGRFAMs	TIGR00263. trpB. 1 hit.
PROSITE	PS00168. TRP_SYNTHASE_BETA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G0BI87_9ENTR

Accession

Primary (citable) accession number: G0BI87

Entry history

Integrated into UniProtKB/TrEMBL:	October 19, 2011
Last sequence update:	October 19, 2011
Last modified:	April 3, 2013
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)