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G0B7F5

- G0B7F5_SERSA

UniProt

G0B7F5 - G0B7F5_SERSA

Protein

Isocitrate dehydrogenase [NADP]

Gene

SerAS9_1976

Organism
Serratia plymuthica (strain AS9)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciSPLY768492:GLK1-2037-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:SerAS9_1976Imported
    OrganismiSerratia plymuthica (strain AS9)Imported
    Taxonomic identifieri768492 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia
    ProteomesiUP000008883: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.
    OMAiCLRPIRY.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G0B7F5-1 [UniParc]FASTAAdd to Basket

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    MESKVVVPAE GKQITVDAQG KLVVPNNPII PFIEGDGIGV DVTPAMIHVV    50
    DAAVKKAYHG ERKISWMEIY TGEKSTHVYG KDVWLPEETL DLIRDYRVAI 100
    KGPLTTPVGG GIRSLNVALR QQLDLYVCLR PVRYYQGTPS PVKQPELTDM 150
    VIFRENAEDI YAGIEWKAGS AEADKVIKFL RDEMGVKKIR FPEQCGIGVK 200
    PCSEEGTKRL VRAAIEYAIT NDRDSVTLVH KGNIMKFTEG AFKDWGYELA 250
    REEFGGELID GGPWLKIKNP NTGKEIVVKD VIADAFLQQI LLRPAEYDVI 300
    ACMNLNGDYI SDALAAQVGG IGIAPGANIG SDCALFEATH GTAPKYAGQD 350
    KVNPGSIILS AEMMLRHMGW FEAADLIVKG MEGAIAAKTV TYDFERLMEG 400
    AKLLKCSEFG DAIVKHM 417
    Length:417
    Mass (Da):45,719
    Last modified:October 19, 2011 - v1
    Checksum:iC1C20D55FBC7A587
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002773 Genomic DNA. Translation: AEF45103.1.
    RefSeqiYP_004505364.1. NC_015567.1.

    Genome annotation databases

    EnsemblBacteriaiAEF45103; AEF45103; SerAS9_1976.
    GeneIDi10621099.
    KEGGisrr:SerAS9_1976.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002773 Genomic DNA. Translation: AEF45103.1 .
    RefSeqi YP_004505364.1. NC_015567.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEF45103 ; AEF45103 ; SerAS9_1976 .
    GeneIDi 10621099.
    KEGGi srr:SerAS9_1976.

    Phylogenomic databases

    KOi K00031.
    OMAi CLRPIRY.

    Enzyme and pathway databases

    BioCyci SPLY768492:GLK1-2037-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AS9Imported.

    Entry informationi

    Entry nameiG0B7F5_SERSA
    AccessioniPrimary (citable) accession number: G0B7F5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 19, 2011
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3