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Protein

DNA mismatch repair protein MutH

Gene

mutH

Organism
Serratia plymuthica (strain AS9)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.UniRule annotationSAAS annotation

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. endonuclease activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA modification Source: InterPro
  2. mismatch repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

EndonucleaseUniRule annotationSAAS annotation, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repairUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSPLY768492:GLK1-4105-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutHUniRule annotationSAAS annotation
Alternative name(s):
Methyl-directed mismatch repair proteinUniRule annotation
Gene namesi
Name:mutHUniRule annotation
Ordered Locus Names:SerAS9_4014Imported
OrganismiSerratia plymuthica (strain AS9)Imported
Taxonomic identifieri768492 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia
ProteomesiUP000008883: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the MutH family.UniRule annotation

Phylogenomic databases

KOiK03573.
OMAiLRPKGAN.

Family and domain databases

Gene3Di3.40.600.10. 1 hit.
HAMAPiMF_00759. MutH.
InterProiIPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamiPF02976. MutH. 1 hit.
[Graphical view]
SMARTiSM00927. MutH. 1 hit.
[Graphical view]
SUPFAMiSSF52980. SSF52980. 1 hit.
TIGRFAMsiTIGR02248. mutH_TIGR. 1 hit.

Sequencei

Sequence statusi: Complete.

G0B2G5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAFLSPLPLP PENEQQLFER AQQLAGFTLG ELAARAQLPI PKDLKRDKGW
60 70 80 90 100
VGMLLELYLG AMAGSKPEQD FPELGIELKT IPIDAAGKPL ETTFVCVAPL
110 120 130 140 150
TGNSGVTWAS SHVRHKLARV LWIPVEGERQ IPLAQRHIGS PLLWSPSAAE
160 170 180 190 200
EEMLRRDWEE LMDLIVLGHV ERITARHGEV LQLRPKAANS KALTEAIGEQ
210 220
GQPILTLPRG FYLKKSFTGA LLARHFLI
Length:228
Mass (Da):25,257
Last modified:October 19, 2011 - v1
Checksum:i2E6E5DAE92C5597D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002773 Genomic DNA. Translation: AEF47114.1.
RefSeqiYP_004507375.1. NC_015567.1.

Genome annotation databases

EnsemblBacteriaiAEF47114; AEF47114; SerAS9_4014.
GeneIDi10623167.
KEGGisrr:SerAS9_4014.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002773 Genomic DNA. Translation: AEF47114.1.
RefSeqiYP_004507375.1. NC_015567.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEF47114; AEF47114; SerAS9_4014.
GeneIDi10623167.
KEGGisrr:SerAS9_4014.

Phylogenomic databases

KOiK03573.
OMAiLRPKGAN.

Enzyme and pathway databases

BioCyciSPLY768492:GLK1-4105-MONOMER.

Family and domain databases

Gene3Di3.40.600.10. 1 hit.
HAMAPiMF_00759. MutH.
InterProiIPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamiPF02976. MutH. 1 hit.
[Graphical view]
SMARTiSM00927. MutH. 1 hit.
[Graphical view]
SUPFAMiSSF52980. SSF52980. 1 hit.
TIGRFAMsiTIGR02248. mutH_TIGR. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AS9Imported.

Entry informationi

Entry nameiG0B2G5_SERSA
AccessioniPrimary (citable) accession number: G0B2G5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: February 4, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.