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Protein

Bifunctional protein PutA

Gene

putA

Organism
Collimonas fungivorans (strain Ter331)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Oxidizes proline to glutamate for use as a carbon and nitrogen source.UniRule annotation

Catalytic activityi

L-glutamate 5-semialdehyde + NAD+ + H2O = L-glutamate + NADH.UniRule annotation
L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: L-proline degradation into L-glutamate

This protein is involved in step 1 and 2 of the subpathway that synthesizes L-glutamate from L-proline.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Bifunctional protein PutA (putA)
  2. Bifunctional protein PutA (putA)
This subpathway is part of the pathway L-proline degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate from L-proline, the pathway L-proline degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei778UniRule annotation1
Active sitei812UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, OxidoreductaseUniRule annotationImported, RepressorUniRule annotation
Biological processProline metabolismUniRule annotation, Transcription, Transcription regulationUniRule annotation
LigandFADUniRule annotation, Flavoprotein, NADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00261; UER00373
UPA00261; UER00374

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein PutAUniRule annotation
Including the following 2 domains:
Proline dehydrogenaseUniRule annotation (EC:1.5.5.2UniRule annotation)
Alternative name(s):
Proline oxidaseUniRule annotation
Delta-1-pyrroline-5-carboxylate dehydrogenaseUniRule annotation (EC:1.2.1.88UniRule annotation)
Short name:
P5C dehydrogenaseUniRule annotation
Alternative name(s):
L-glutamate gamma-semialdehyde dehydrogenaseUniRule annotation
Gene namesi
Name:putAImported
Ordered Locus Names:CFU_4418Imported
OrganismiCollimonas fungivorans (strain Ter331)Imported
Taxonomic identifieri1005048 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeCollimonas
Proteomesi
  • UP000008392 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi1005048.CFU_4418

Structurei

3D structure databases

ProteinModelPortaliG0AEN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 166Pro_dh-DNA_bdgInterPro annotationAdd BLAST112
Domaini179 – 472Pro_dhInterPro annotationAdd BLAST294
Domaini559 – 998AldedhInterPro annotationAdd BLAST440

Sequence similaritiesi

In the C-terminal section; belongs to the aldehyde dehydrogenase family.UniRule annotation
In the N-terminal section; belongs to the proline dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C26 Bacteria
COG0506 LUCA
COG4230 LUCA
KOiK13821
OMAiVRIYAPV
OrthoDBiPOG091H043M

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR025703 Bifunct_PutA
IPR005933 Delta1-pyrroline-5-COlate_DH-3
IPR029041 FAD-linked_oxidoreductase-like
IPR024089 PRODH_PutA_dom_I/II
IPR024082 PRODH_PutA_dom_II
IPR002872 Proline_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PF01619 Pro_dh, 1 hit
PF14850 Pro_dh-DNA_bdg, 1 hit
PIRSFiPIRSF000197 Bifunct_PutA, 1 hit
SUPFAMiSSF51730 SSF51730, 1 hit
SSF53720 SSF53720, 1 hit
SSF81935 SSF81935, 1 hit
TIGRFAMsiTIGR01238 D1pyr5carbox3, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit

Sequencei

Sequence statusi: Complete.

G0AEN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAAITAAYR RDETLAVQWL LAQVQTSAGA HAASQALARK LVQAVREKRT
60 70 80 90 100
RASGVDALMH EFSLSSEEGV ALMCLAEALL RIPDHQTADR LIADKISKGD
110 120 130 140 150
WGSHLGESPS LFVNAATWGL LITGKLVATN SERGLGSALT KLIGRGGEPL
160 170 180 190 200
IRKGVDVAMR MLGNQFVTGQ TIAEALGNSR DNEKRGYRYS YDMLGEAALT
210 220 230 240 250
EEDAAAYYRS YEDAIHAIGK ASNGRGIKQG PGISVKLSAL HPRYSRAQRQ
260 270 280 290 300
RTMEELLPRL KQLLLLAKQY DIGLNIDAEE ADRLELSLDL MEALAFDPEL
310 320 330 340 350
AGFEGIGFVV QGYQKRCPFV IDYLVDLAHR SGRKFMVRLV KGAYWDSEIK
360 370 380 390 400
RAQVDGLPGF PVYTRKVYTD VSYLTCAQKL LASTDVIYPQ FATHNAHTLA
410 420 430 440 450
TIYSWAQEKK ITDYEFQCLH GMGETLYDQV VGKDMLDKPC RIYAPVGSHQ
460 470 480 490 500
TLLAYLVRRL LENGANSSFV NQIVDESVSI DSLIADPLQA AQQLGGEPHP
510 520 530 540 550
QIALPPAMYG AERKNSAGLD LSSEEVLRQI DSAFGVFGKQ QWHATPMLAE
560 570 580 590 600
LQTYSQAVRP VLNPADQRDV VGSVVEASVA DVDKALHAAS VYAMDWQTLP
610 620 630 640 650
PAERADKLDR AAALFEVHQL ELIALAIREA GKSLPNAIAE VREAVDFLRY
660 670 680 690 700
YAAQVRHTQN ALALGPVVCI SPWNFPLAIF IGEVSAALAA GNVVLAKPAE
710 720 730 740 750
QTPLIAARAV QLLHEAGVPP AALQFLPGQG DTVGATLTAD ARVKGVIFTG
760 770 780 790 800
STEVAQIISR TLAKRSLAES VDLPLIAETG GQNALIVDSS ALPEQVVQDV
810 820 830 840 850
LSSAFDSAGQ RCSALRVLCL QNDIADRTLH MLKGAMQELR IGNPDRLVTD
860 870 880 890 900
IGPVIDTDAQ GQLLAHIETM RATAKDFYQL PLPPEQHHGT FVAPTLIEIG
910 920 930 940 950
SMSELKREVF GPVLHVLRYA RNELPQLVDA INGSGYGLTL GIHSRIDETI
960 970 980 990 1000
DFIVARAHVG NIYVNRNIVG AVVGVQPFGG EGKSGTGPKA GGPLYLKRLQ
1010 1020 1030 1040 1050
RNPAVSLGAH TIHAPNPEAA NATPVLQALL SWARTHGHQR IAALGEEYMH
1060 1070 1080 1090 1100
ASWLGTSLVL PGPTGERNSL SFAPRGAILC SADNVGAMLN QLAAVFATGN
1110 1120 1130 1140 1150
LPVVEAGSSA MIPEGLPRAV RAAIRVVDQL AGSDHATRLQ LALVDGAGTV
1160 1170 1180 1190 1200
RLRPLLTALG EQSGALVPLL ETSEYASIPL WRLLAERAVC VNTTAAGGNA

SLMTLQA
Length:1,207
Mass (Da):129,846
Last modified:October 19, 2011 - v1
Checksum:i9EA53A95918A6C0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002745 Genomic DNA Translation: AEK64239.1

Genome annotation databases

EnsemblBacteriaiAEK64239; AEK64239; CFU_4418
KEGGicfu:CFU_4418

Similar proteinsi

Entry informationi

Entry nameiG0AEN1_COLFT
AccessioniPrimary (citable) accession number: G0AEN1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: March 28, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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