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Protein

Isocitrate dehydrogenase [NADP]

Gene

icdA

Organism
Collimonas fungivorans (strain Ter331)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciCFUN1005048:GJNH-3290-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdAImported
Ordered Locus Names:CFU_3268Imported
OrganismiCollimonas fungivorans (strain Ter331)Imported
Taxonomic identifieri1005048 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeCollimonas
ProteomesiUP000008392 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.
OMAiFRDWGYE.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G0ACY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQHIKVPAE GKKITVNADF SINVPDNPII PYIEGDGTGV DISPVMIKVV
60 70 80 90 100
DAAVSKAYAG KRKISWMEVF AGEKSTKVYG PDVWLPEETL AAIKDYVVSI
110 120 130 140 150
KGPLTTPVGG GIRSLNVALR QELDLYVCLR PVRYFKGVPS PVREPEKTDM
160 170 180 190 200
VIFRENSEDI YAGIEWQEGS DGAKKLIEFL IKEMGVKKIR FPDTSGIGVK
210 220 230 240 250
PVSREGTERL VRKAIQYAID NDKPSVTIVH KGNIMKFTEG GFRDWAYALA
260 270 280 290 300
QKEFGAELID GGPWAKFKNP KTGREIIVKD SIADAFLQQI LLRPNEYSVI
310 320 330 340 350
ATLNLNGDYI SDALAAQVGG IGIAPGANLS DSVAMFEATH GTAPKYAGKD
360 370 380 390 400
YVNPGSLILS AEMMLRHMGW VEAADLIIES MQKSITSKKV TYDFARLMEG
410
ATQVSCSGFG EVLIENM
Length:417
Mass (Da):45,601
Last modified:October 19, 2011 - v1
Checksum:i185204F826785EBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002745 Genomic DNA. Translation: AEK63092.1.
RefSeqiWP_014007244.1. NC_015856.1.
YP_004753915.1. NC_015856.1.

Genome annotation databases

EnsemblBacteriaiAEK63092; AEK63092; CFU_3268.
KEGGicfu:CFU_3268.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002745 Genomic DNA. Translation: AEK63092.1.
RefSeqiWP_014007244.1. NC_015856.1.
YP_004753915.1. NC_015856.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEK63092; AEK63092; CFU_3268.
KEGGicfu:CFU_3268.

Phylogenomic databases

KOiK00031.
OMAiFRDWGYE.

Enzyme and pathway databases

BioCyciCFUN1005048:GJNH-3290-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Collimonas fungivorans Ter331."
    Leveau J.H.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ter331Imported.

Entry informationi

Entry nameiG0ACY7_COLFT
AccessioniPrimary (citable) accession number: G0ACY7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: April 29, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.