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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Methylomonas methanica (strain MC09)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei147 – 1471UniRule annotation
Active sitei591 – 5911UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciMMET857087:GH4A-3283-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:Metme_3258Imported
OrganismiMethylomonas methanica (strain MC09)Imported
Taxonomic identifieri857087 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylomonas
ProteomesiUP000008888 Componenti: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

KOiK01595.
OMAiFTSNWEL.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G0A5C4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRTPEYDDK TLRANIRLLK GMLDNVLKNQ ASHQVAEIVE QLQRQFTVLQ
60 70 80 90 100
RDNNPAKRQQ ILKTLHNLPA ETLSEVIRAF SLYFSLLNIA EESTQLQHRR
110 120 130 140 150
HQIEKNKHYW RGSFHDTLLA FKNAGISAEQ LQPLLDDLHY LPVMTAHPTE
160 170 180 190 200
AKRRTVRGAL RSVFVSHEKL QNSGIKGYFR DVALERLQSQ IQLLWKTDEV
210 220 230 240 250
RAHSMGVIDE IDSGLFYFPL SLFEATAQVY RNFQRALVDV YGSDAASKVN
260 270 280 290 300
IPSFLNFGSW IGGDRDGNPN VKPHTTALAL RLQARTITRE YLRRIDILLE
310 320 330 340 350
QLAYSHGMCQ PTEAFLQSLQ NDRDLLGDTA ITLERNYLQE PYRHKLALMK
360 370 380 390 400
FRMHRRMELL EQRIAGDSSQ SDDQAYNNIQ TFHADLCLIR ESLSSHGDQA
410 420 430 440 450
IADRDLQDLI RLVDIFGFYL MQLDVRQEST RHSQAVAEIL SAGLGIDYLS
460 470 480 490 500
MDEDQRMQVL SEAIAIPGGL GYDASELSAA TVETLDVFQV MAQMRREIGN
510 520 530 540 550
DCFSRYVISM THSASHIMEV LLLAAQNGLA GRISGQWYCH IGVSPLFETI
560 570 580 590 600
DDLNHIDGVL RSLLSQPAYR ALLEASGLRQ EVMLGYSDSC KDGGILASAW
610 620 630 640 650
GLYRAQQQVT AISDDVGIPC RLFHGRGGTI GRGGGPTHEA ILAQPPATVR
660 670 680 690 700
GQIKFTEQGE VLFYRYNNME TAIYELTMGI TGLMKASVSL IQPVEPDRPD
710 720 730 740 750
NLQLMGELAQ LGERSYRQLT EHTPGFLDYF YEATPVQEIG QLNIGSRPSH
760 770 780 790 800
RKKADRSKYS VRAIAWVFAW AQSRQTFPAW YGIGSSLESY CAGNPERLQA
810 820 830 840 850
LRELYKNWPF FRNLLSNAQM ALSKSDMTIA EEYSSLCSDP EAGKRVHGLI
860 870 880 890 900
AGEHRRCVDW VLEIAECDQL LAENPELAAS LRRRNDYLGP LNYMQAGLLR
910 920 930
ALNEDEDANG QSRWMNPLLR TINAIAAGMR NTG
Length:933
Mass (Da):105,347
Last modified:October 19, 2011 - v1
Checksum:iDA41ADDFB161FC51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002738 Genomic DNA. Translation: AEG01630.1.
RefSeqiWP_013819857.1. NC_015572.1.
YP_004514129.1. NC_015572.1.

Genome annotation databases

EnsemblBacteriaiAEG01630; AEG01630; Metme_3258.
KEGGimmt:Metme_3258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002738 Genomic DNA. Translation: AEG01630.1.
RefSeqiWP_013819857.1. NC_015572.1.
YP_004514129.1. NC_015572.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEG01630; AEG01630; Metme_3258.
KEGGimmt:Metme_3258.

Phylogenomic databases

KOiK01595.
OMAiFTSNWEL.

Enzyme and pathway databases

BioCyciMMET857087:GH4A-3283-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of the aerobic marine methanotroph Methylomonas methanica MC09."
    Boden R., Cunliffe M., Scanlan J., Moussard H., Kits K.D., Klotz M., Jetten M., Vuilleumier S., Han J., Peters L., Mikhailova N., Teshima H., Tapia R., Kyrpides N., Ivanova N., Pagani I., Cheng J.-F., Goodwin L.
    , Han C., Hauser L., Land M., Lapidus A., Lucas S., Pitluck S., Woyke T., Stein L.Y., Murrell C.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MC09.
  2. "Complete sequence of Methylomonas methanica MC09."
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Teshima H., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Stein L., Woyke T.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MC09Imported.

Entry informationi

Entry nameiG0A5C4_METMM
AccessioniPrimary (citable) accession number: G0A5C4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: April 29, 2015
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.